دورية أكاديمية
The effect of paramagnetic contrast in choline peak in patients with glioblastoma multiforme might not be significant.
| العنوان: | The effect of paramagnetic contrast in choline peak in patients with glioblastoma multiforme might not be significant. |
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| المؤلفون: | Lima EC; Department of Radiology, University of Sao Paulo, Sao Paulo, Brazil. eduardocl@einstein.br, Otaduy MC, Tsunemi M, Pincerato R, Cardoso EF, Rosemberg S, Aguiar PH, Cerri GG, Leite CC |
| المصدر: | AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 2013 Jan; Vol. 34 (1), pp. 80-4. Date of Electronic Publication: 2012 Jul 05. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Neuroradiology Country of Publication: United States NLM ID: 8003708 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-959X (Electronic) Linking ISSN: 01956108 NLM ISO Abbreviation: AJNR Am J Neuroradiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oak Brook, IL : American Society of Neuroradiology Original Publication: Baltimore, Williams & Wilkins. |
| مواضيع طبية MeSH: | Contrast Media*/administration & dosage , Gadolinium*/administration & dosage, Brain/*metabolism , Brain Neoplasms/*metabolism , Choline/*analysis , Electron Spin Resonance Spectroscopy/*methods , Glioblastoma/*metabolism, Adult ; Aged ; Aged, 80 and over ; Brain/drug effects ; Brain/pathology ; Brain Neoplasms/diagnosis ; Female ; Glioblastoma/diagnosis ; Humans ; Male ; Middle Aged ; Reproducibility of Results ; Sensitivity and Specificity |
| مستخلص: | Background and Purpose: (1)H-MR spectroscopy is a useful tool in brain tumor evaluation. A critical point in obtaining representative spectra is the correct voxel positioning, which can be more accurate after Gd administration. Some experimental data suggested that Gd could cause Cho signal loss. Our aim was to evaluate the effect of Gd in the Cho peak area and width in patients with GBM. Materials and Methods: We performed multivoxel (1)H-MR spectroscopy before and after Gd administration in 18 patients with GBM. Quantification of Cho peak area and width in each voxel was completed, and the Cho mean and maximum values before and after Gd injection were calculated in the tumor and contralateral hemisphere. Choline peak area and width values obtained before and after contrast were compared, considering as separate entities enhancing and nonenhancing tumoral voxels and the contralateral hemisphere. Results: No statistically significant differences were found for the Cho peak area mean values in the tumoral voxels or contralaterally (P > .05). A tendency for an increase in the Cho peak width mean value was found in the tumoral enhancing voxels (P = .055). A statistically significant decrease was found for the mean value of the maximum Cho peak area in enhancing tumoral voxels (P = .020). No significant differences were found in the nonenhancing tumoral voxels or contralaterally (P > .05). Conclusions: The injection of Gd before performing (1)H-MR spectroscopy might not significantly affect the Cho peak area in patients with GBM. The paramagnetic contrast seems to cause a different effect, depending on Gd enhancement. |
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| المشرفين على المادة: | 0 (Contrast Media) AU0V1LM3JT (Gadolinium) N91BDP6H0X (Choline) |
| تواريخ الأحداث: | Date Created: 20120707 Date Completed: 20130711 Latest Revision: 20211021 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC7966339 |
| DOI: | 10.3174/ajnr.A3181 |
| PMID: | 22766678 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1936-959X |
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| DOI: | 10.3174/ajnr.A3181 |