دورية أكاديمية
Significant impact of recurrent respiratory tract infections in children with Down syndrome.
| العنوان: | Significant impact of recurrent respiratory tract infections in children with Down syndrome. |
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| المؤلفون: | Verstegen RH; Department of Pediatrics, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands., van Gameren-Oosterom HB, Fekkes M, Dusseldorp E, de Vries E, van Wouwe JP |
| المصدر: | Child: care, health and development [Child Care Health Dev] 2013 Nov; Vol. 39 (6), pp. 801-9. Date of Electronic Publication: 2012 Jul 09. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 7602632 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2214 (Electronic) Linking ISSN: 03051862 NLM ISO Abbreviation: Child Care Health Dev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, Blackwell Scientific Publications. |
| مواضيع طبية MeSH: | Child Behavior Disorders/*etiology , Down Syndrome/*complications , Respiratory Tract Infections/*complications, Child ; Child Behavior Disorders/epidemiology ; Developmental Disabilities ; Down Syndrome/psychology ; Female ; Humans ; Male ; Netherlands/epidemiology ; Observational Studies as Topic ; Parents/psychology ; Quality of Life ; Recurrence ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/prevention & control ; Surveys and Questionnaires |
| مستخلص: | Objective: Parents and health professionals believe that recurrent respiratory tract infections (RRTI) have a large impact on children with Down syndrome (DS). We studied the relation between parent-reported RRTI and development, behaviour and health-related quality of life (HRQoL) in 8-year-old children with DS. Method: During a 3-year period, 325 children with DS were recruited for inclusion in this observational study. Parents were asked to fill in the Child Behavior Checklist and TNO-AZL Children's Quality of Life Parent Form. A psychological assistant administrated the McCarthy Scales of Children's Abilities. The children were divided into a group with presence of RRTI (RRTI (+) ) and a group without RRTI (RRTI (-) ), on the basis of parental report. Linear regression analyses were performed to assess the effect of RRTI, while correcting for the influence of confounders. Results: Compared with RRTI (-) children (n = 176), RRTI (+) children (n = 149, 46%) showed decreased mental and motor development (mean developmental age 3.67 vs. 4.08 years), more behavioural problems and lower scores on most HRQoL scales (P < 0.05). Moreover, school enrolment is less favourable in RRTI (+) children. Conclusion: In 8-year-olds with DS, the children with parent-reported RRTI show more delayed development, more behavioural problems and lower HRQoL compared with the children without RRTI. Although this association does not prove a causal relationship, further studies should focus on this, because RRTI are potentially preventable. (© 2012 John Wiley & Sons Ltd.) |
| فهرسة مساهمة: | Keywords: Down syndrome; behaviour; development; health-related quality of life; recurrent respiratory tract infections |
| تواريخ الأحداث: | Date Created: 20120711 Date Completed: 20150209 Latest Revision: 20151119 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/j.1365-2214.2012.01413.x |
| PMID: | 22774862 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1365-2214 |
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| DOI: | 10.1111/j.1365-2214.2012.01413.x |