دورية أكاديمية
أعرض في EDS

Finding the origin of pulmonary emboli with a total-body magnetic resonance direct thrombus imaging technique.

التفاصيل البيبلوغرافية
العنوان: Finding the origin of pulmonary emboli with a total-body magnetic resonance direct thrombus imaging technique.
المؤلفون: van Langevelde K; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Srámek A, Vincken PW, van Rooden JK, Rosendaal FR, Cannegieter SC
المصدر: Haematologica [Haematologica] 2013 Feb; Vol. 98 (2), pp. 309-15. Date of Electronic Publication: 2012 Jul 16.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Ferrata Storti Foundation Country of Publication: Italy NLM ID: 0417435 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1592-8721 (Electronic) Linking ISSN: 03906078 NLM ISO Abbreviation: Haematologica Subsets: MEDLINE
أسماء مطبوعة: Publication: 1999- : Pavia, Italy : Ferrata Storti Foundation
Original Publication: Pavia [etc.]
مواضيع طبية MeSH: Magnetic Resonance Imaging*, Pulmonary Embolism/*diagnosis, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Pulmonary Embolism/etiology ; Risk Factors ; Thrombosis/diagnosis ; Young Adult
مستخلص: Pulmonary embolism is considered to originate from embolization of a deep-vein thrombosis, resulting in two manifestations of one disease: venous thrombosis. However, in up to 50% of patients with pulmonary embolism no deep-vein thrombosis is found with ultrasonography. An explanation for this low proportion is currently lacking. Other imaging modalities may increase the yield of detection of deep-vein thrombosis in the calf or in the abdominal region. Alternatively, not all pulmonary emboli may originate from deep-vein thromboses in the extremities. We searched for the origin of pulmonary emboli, by performing total-body magnetic resonance imaging-scans to visualize thrombi. Ninety-nine patients with a first pulmonary embolism confirmed by computed tomography underwent a magnetic resonance direct thrombus imaging-scan, a validated technique using endogenous contrast. Additionally, acquired and genetic risk factors were assessed. No thrombus was found in 55 patients, whereas a thrombus was identified in 44 patients. The commonest thrombus location was the lower leg; 12 patients had isolated calf vein thrombosis and five had isolated superficial vein thrombosis. A peripheral thrombus was found by magnetic resonance imaging in less than half of patients with pulmonary embolism. We propose several hypotheses to explain the absence of thrombi, such as a cardiac thrombus origin or embolization of the whole deep-vein thrombus. The possibility that pulmonary embolism arises de novo in the lungs, due to local inflammation-driven coagulation, needs to be considered.
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تواريخ الأحداث: Date Created: 20120718 Date Completed: 20131125 Latest Revision: 20220408
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC3561441
DOI: 10.3324/haematol.2012.069195
PMID: 22801962
قاعدة البيانات: MEDLINE
الوصف
تدمد:1592-8721
DOI:10.3324/haematol.2012.069195