دورية أكاديمية
OAT and 3'MeDAB azo compounds similarly cause liver tumors in GR mice, but differently modify activities of FoxA transcription factors.
| العنوان: | OAT and 3'MeDAB azo compounds similarly cause liver tumors in GR mice, but differently modify activities of FoxA transcription factors. |
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| المؤلفون: | Pakharukova MY; Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. pmaria@yandex.ru, Smetanina MA, Ilnitskaya SI, Kaledin VI, Merkulova TI |
| المصدر: | Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2011 Nov; Vol. 152 (1), pp. 101-4. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English; Russian |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 0372557 Publication Model: Print Cited Medium: Internet ISSN: 1573-8221 (Electronic) Linking ISSN: 00074888 NLM ISO Abbreviation: Bull Exp Biol Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Springer Original Publication: New York, Consultants Bureau. |
| مواضيع طبية MeSH: | Azo Compounds/*toxicity , Benzene Derivatives/*toxicity , Hepatocyte Nuclear Factors/*metabolism , Liver Neoplasms/*chemically induced , o-Aminoazotoluene/*toxicity, Animals ; Azo Compounds/pharmacology ; Benzene Derivatives/pharmacology ; Female ; Glucocorticoids ; Liver/drug effects ; Liver/metabolism ; Liver Neoplasms/metabolism ; Male ; Mice ; Protein Binding ; Proto-Oncogene Proteins c-ets/metabolism ; Transcriptional Activation/drug effects ; o-Aminoazotoluene/pharmacology |
| مستخلص: | Transcription factors of the FoxA family (forkhead box A) regulate cell metabolism and differentiation and maintain specificity of liver cell proteome and phenotype of mature hepatocytes. The relationship between hepatocarcinogenicity of azo compounds o-aminoazotoluene (OAT) and 3'-methyl-4-dimethylaminobenzene (3'MeDAB) for GR mice and one of the early events, modulation of the DNA-binding activity of FoxA transcription factor, was studied. Single injection of 3'MeDAB to 12-day-old mice caused liver tumors in 100% males and females similarly as OAT, a well-known mouse hepatocarcinogene. The DNA-binding activity of FoxA in the liver decreased 2.5-3 times by OAT, this resulting in a 40% reduction of glucocorticoid induction of tyrosine aminotransferase (liver-specific gene). In contrast to these, 3'MeDAB did not modify FoxA protein activities or the degree of glucocorticoid induction of tyrosine aminotransferase. |
| المشرفين على المادة: | 0 (3'-methyl 4-dimethylazobenzene) 0 (Azo Compounds) 0 (Benzene Derivatives) 0 (Glucocorticoids) 0 (Hepatocyte Nuclear Factors) 0 (Proto-Oncogene Proteins c-ets) QHZ900P7ZA (o-Aminoazotoluene) |
| تواريخ الأحداث: | Date Created: 20120718 Date Completed: 20121119 Latest Revision: 20190813 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s10517-011-1465-y |
| PMID: | 22803052 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1573-8221 |
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| DOI: | 10.1007/s10517-011-1465-y |