دورية أكاديمية
Mechanisms of action of ladasten: activation of gene expression for neurotrophins and mitogen-activated kinases.
| العنوان: | Mechanisms of action of ladasten: activation of gene expression for neurotrophins and mitogen-activated kinases. |
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| المؤلفون: | Salimgareeva MKh; Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences, Moscow, Russia. milyausha78@mail.ru, Yamidanov RS, Vakhitova YV, Seredenin SB |
| المصدر: | Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2012 Jan; Vol. 152 (3), pp. 313-7. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 0372557 Publication Model: Print Cited Medium: Internet ISSN: 1573-8221 (Electronic) Linking ISSN: 00074888 NLM ISO Abbreviation: Bull Exp Biol Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Springer Original Publication: New York, Consultants Bureau. |
| مواضيع طبية MeSH: | Adamantane/*analogs & derivatives , Extracellular Signal-Regulated MAP Kinases/*metabolism , Gene Expression Regulation/*drug effects , Nerve Growth Factors/*metabolism , Signal Transduction/*drug effects, Adamantane/administration & dosage ; Adamantane/pharmacology ; Animals ; Brain-Derived Neurotrophic Factor/metabolism ; Corpus Striatum/metabolism ; Densitometry ; Gene Expression Regulation/physiology ; Hippocampus/metabolism ; Hypothalamus/metabolism ; Immunoblotting ; Male ; Rats |
| مستخلص: | We studied the effects of single treatment with ladasten (50 mg/kg) on the content of effector kinases of the mitogen-activated cascade (ERK1/ERK2), pERK1/ERK2 activity (Thr202/Tyr204), and expression of genes for neurotrophic factors BDND and NGF in the striatum, hypothalamus, and hippocampus of rats. |
| المشرفين على المادة: | 0 (Brain-Derived Neurotrophic Factor) 0 (N-(2-adamantyl)-N-p-bromophenylamine) 0 (Nerve Growth Factors) EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases) PJY633525U (Adamantane) |
| تواريخ الأحداث: | Date Created: 20120718 Date Completed: 20160322 Latest Revision: 20190813 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s10517-012-1516-z |
| PMID: | 22803074 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1573-8221 |
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| DOI: | 10.1007/s10517-012-1516-z |