دورية أكاديمية
Morphometric analysis of atherosclerotic plaques in human carotid arteries.
| العنوان: | Morphometric analysis of atherosclerotic plaques in human carotid arteries. |
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| المؤلفون: | Shishkina VS; Institute of Experimental Cardiology, Moscow, Russia. ShishkinaValya@mail.ru, Kashirina SV, Sirotkin VN, Il'inskaya OP, Tararak EM |
| المصدر: | Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2012 Mar; Vol. 152 (5), pp. 642-5. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English; Russian |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 0372557 Publication Model: Print Cited Medium: Internet ISSN: 1573-8221 (Electronic) Linking ISSN: 00074888 NLM ISO Abbreviation: Bull Exp Biol Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Springer Original Publication: New York, Consultants Bureau. |
| مواضيع طبية MeSH: | Research Design*, Atherosclerosis/*pathology , Carotid Arteries/*pathology , Plaque, Atherosclerotic/*ultrastructure, Aged ; Calcinosis/pathology ; Collagen/ultrastructure ; Connective Tissue/pathology ; Endarterectomy, Carotid ; Extracellular Matrix/ultrastructure ; Female ; Histocytochemistry ; Humans ; Image Processing, Computer-Assisted ; Male ; Middle Aged |
| مستخلص: | Morphometric analysis of 35 biopsy specimens from patients with stable (n=10) and unstable (n=25) atherosclerotic lesions was carried out. The structure of the plaques and their connective tissue caps was studied by various methods of histological sections staining. A new morphometric approach to quantitative evaluation of atherosclerotic lesions instability is suggested. It consists in calculation of the morphological "rigidity" coefficient, due to which the plaque is characterized more accurately. The proportion of areas of the "rigid" (connective tissue and calcium salt deposition areas) to "soft" (atheronecrotic nuclei, microvessels, clots and hemorrhages) structures of the plaque is evaluated. Plaque instability (liability of a to rupture) is associated with changes in the extracellular matrix components in the cap: accumulation of collagen and reduction of elastic fiber content reducing vessel elasticity and making its locally more rigid. |
| المشرفين على المادة: | 9007-34-5 (Collagen) |
| تواريخ الأحداث: | Date Created: 20120718 Date Completed: 20121113 Latest Revision: 20190813 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1007/s10517-012-1597-8 |
| PMID: | 22803155 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1573-8221 |
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| DOI: | 10.1007/s10517-012-1597-8 |