دورية أكاديمية
Absolute bioavailability of himantane in rabbits.
| العنوان: | Absolute bioavailability of himantane in rabbits. |
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| المؤلفون: | Litvin EA; V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. zlanomar@gmail.com, Bastrygin DV, Kolyvanov GB, Alekseev KV, Zherdev VP |
| المصدر: | Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2012 Jun; Vol. 153 (2), pp. 206-8. |
| نوع المنشور: | Journal Article |
| اللغة: | English; Russian |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 0372557 Publication Model: Print Cited Medium: Internet ISSN: 1573-8221 (Electronic) Linking ISSN: 00074888 NLM ISO Abbreviation: Bull Exp Biol Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Springer Original Publication: New York, Consultants Bureau. |
| مواضيع طبية MeSH: | Adamantane/*analogs & derivatives, Adamantane/administration & dosage ; Adamantane/blood ; Adamantane/metabolism ; Adamantane/pharmacokinetics ; Administration, Oral ; Animals ; Biological Availability ; Cross-Over Studies ; Injections, Intravenous ; Liver/drug effects ; Liver/metabolism ; Male ; Rabbits |
| مستخلص: | Pharmacokinetic parameters of himantane and its metabolites in the blood plasma of rabbits were compared after single administration of himantane solution in a dose of 25 mg intravenously and 100 mg orally. It was established that the original substance is characterized by low absolute bioavailability (7.95%). Himantane is subjected to first-pass effect and is extensively metabolized in the liver to metabolites with m/z 266 and 250. |
| المشرفين على المادة: | 0 (N-(2-adamantyl)hexamethylenimine) PJY633525U (Adamantane) |
| تواريخ الأحداث: | Date Created: 20120721 Date Completed: 20130129 Latest Revision: 20190813 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s10517-012-1677-9 |
| PMID: | 22816084 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1573-8221 |
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| DOI: | 10.1007/s10517-012-1677-9 |