دورية أكاديمية
[The oxidation stress, lipid metabolism and their relationship in patients with severe course of hypertension disease in aggregate with carotid stenosis].
| العنوان: | [The oxidation stress, lipid metabolism and their relationship in patients with severe course of hypertension disease in aggregate with carotid stenosis]. |
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| المؤلفون: | Klychnikova EV, Matveev SB, Riabinin VA, Godkov MA, Golikov AP, Akhmetov VV, Mikhaĭlov IP |
| المصدر: | Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2012 May (5), pp. 20-2. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Meditsina Country of Publication: Russia (Federation) NLM ID: 9432021 Publication Model: Print Cited Medium: Print ISSN: 0869-2084 (Print) Linking ISSN: 08692084 NLM ISO Abbreviation: Klin Lab Diagn Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Moskva : "Meditsina", 1992- |
| مواضيع طبية MeSH: | Lipid Peroxidation* , Oxidative Stress*, Carotid Stenosis/*blood , Hypertension/*blood, Aged ; Carotid Stenosis/complications ; Carotid Stenosis/surgery ; Ceruloplasmin/metabolism ; Endarterectomy, Carotid ; Female ; Humans ; Hypertension/complications ; Hypertension/surgery ; Lipoproteins, VLDL/blood ; Male ; Malondialdehyde/blood ; Middle Aged ; Nitric Oxide/blood ; Peptidyl-Dipeptidase A/blood ; alpha-Tocopherol/blood |
| مستخلص: | The experimental samplings consisted of 25 patients with severe course of hypertension disease in aggregate with atherogenic carotid stenosis before and after carotid endarterectomy and 21 donors. The study was organized to analyze in lipid profile blood serum the content of malonic dialdehyde, ceruloplasmin, alpha-tocopherol, nitric oxide and angiotensin converting enzyme. The study established that in patients took place a reliably increased level of malonic dialdehyde, ceruloplasmin, alpha-tocopherol, nitric oxide and angiotensin converting enzyme. The patients with this pathology have a reliable positive correlation between the concentration of malonic dialdehydeand lipoproteids of very low density (r = 0.51), malonic dialdehyde and triglycerides (r = 0.36), malonic dialdehyde and cholesterol (r = 0.3). This data confirms the important role of peroxidation of lipids in the development of atherosclerosis. Therefore, the enhancement of oxidation stress and expressed dislipoproteidemia are established in patients with hypertension disease with carotids atherosclerosis as a background. This result testifies the pathogenic significance of these phenomena in the mechanisms of homeostasis disorders. |
| المشرفين على المادة: | 0 (Lipoproteins, VLDL) 31C4KY9ESH (Nitric Oxide) 4Y8F71G49Q (Malondialdehyde) EC 1.16.3.1 (Ceruloplasmin) EC 3.4.15.1 (Peptidyl-Dipeptidase A) H4N855PNZ1 (alpha-Tocopherol) |
| تواريخ الأحداث: | Date Created: 20120728 Date Completed: 20120820 Latest Revision: 20190816 |
| رمز التحديث: | 20231215 |
| PMID: | 22834152 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0869-2084 |
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