دورية أكاديمية
أعرض في EDS

Tract-based diffusion tensor imaging in patients with schizophrenia and their non-psychotic siblings.

التفاصيل البيبلوغرافية
العنوان: Tract-based diffusion tensor imaging in patients with schizophrenia and their non-psychotic siblings.
المؤلفون: Boos HB; Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. h.b.m.boos@umcutrecht.nl, Mandl RC, van Haren NE, Cahn W, van Baal GC, Kahn RS, Hulshoff Pol HE
المصدر: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology [Eur Neuropsychopharmacol] 2013 Apr; Vol. 23 (4), pp. 295-304. Date of Electronic Publication: 2012 Jul 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9111390 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7862 (Electronic) Linking ISSN: 0924977X NLM ISO Abbreviation: Eur Neuropsychopharmacol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam : Elsevier, c1990-
مواضيع طبية MeSH: Psychotic Disorders* , Siblings*, Diffusion Tensor Imaging/*methods , Schizophrenia/*diagnosis , Schizophrenia/*metabolism, Adolescent ; Adult ; Female ; Humans ; Male ; Middle Aged ; Schizophrenia/genetics ; Young Adult
مستخلص: Structural brain abnormalities have consistently been found in patients with schizophrenia. Diffusion tensor imaging (DTI) has been shown to be a useful method to measure white matter (WM) integrity in this illness, but findings in the earlier disease stages are inconclusive. Moreover, the relationship between WM microstructure and the familial risk for developing schizophrenia remains unresolved. From 126 patients with schizophrenia, 123 of their non-psychotic siblings and 109 healthy control subjects, DTI images were acquired on a 1.5 T MRI scanner. Mean fractional anisotropy (FA) was compared along averaged WM tracts, computed for the genu, splenium, left and right uncinate fasciculus, cingulum, inferior fronto-occipital fasciculus, fornix, arcuate fasciculus, and inferior longitudinal fasciculus. Fractional anisotropy (FA) was assessed for its unique environmental and familial (possibly heritable) aspects associated with schizophrenia, using structural equation modeling for these white matter tracts. The results of this study show that young adult (mean age 26.7 years) patients with schizophrenia did not differ in mean FA from healthy controls along WM fibers; siblings of patients showed higher mean FA in the left and right arcuate fasciculus as compared to patients and controls. With increasing age, an excessive decline in mean FA was found in patients as compared to siblings and healthy controls in the genu, left uncinate fasciculus, left inferior fronto-occipital fasciculus, and left inferior longitudinal fasciculus. Moreover, symptom severity was negatively correlated to mean FA in the arcuate fasciculus bilaterally in patients with schizophrenia. In young adult patients with schizophrenia integrity of individual tract-based (corticocortical) fibers can (still) be within normal limits. However, changes in the arcuate fasciculus may be relevant to (the risk to develop) psychosis, while a general and widespread loss of fiber integrity may be related to illness progression.
(Copyright © 2012 Elsevier B.V. and ECNP. All rights reserved.)
تواريخ الأحداث: Date Created: 20120731 Date Completed: 20140106 Latest Revision: 20130402
رمز التحديث: 20240628
DOI: 10.1016/j.euroneuro.2012.05.015
PMID: 22841128
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-7862
DOI:10.1016/j.euroneuro.2012.05.015