دورية أكاديمية
Lifestyle intervention in non-alcoholic fatty liver disease in Chengyang District, Qingdao, China.
| العنوان: | Lifestyle intervention in non-alcoholic fatty liver disease in Chengyang District, Qingdao, China. |
|---|---|
| المؤلفون: | Sun WH; Wei-Hui Sun, Jian-Lin Ma, Ying-Xun Liu, Lei Ma, Qiang Wan, Lin Zhou, Rong Ren, Ling-Fang Meng, Hepatology Department, Qingdao Chengyang People's Hospital, Qingdao 266100, Shandong Province, China., Song MQ, Jiang CQ, Xin YN, Ma JL, Liu YX, Ma L, Lin ZH, Li CY, Liu L, Zhang M, Chu LL, Jiang XJ, Wan Q, Zhou L, Ren R, Meng LF |
| المصدر: | World journal of hepatology [World J Hepatol] 2012 Jul 27; Vol. 4 (7), pp. 224-30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 101532469 Publication Model: Print Cited Medium: Internet ISSN: 1948-5182 (Electronic) NLM ISO Abbreviation: World J Hepatol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group Original Publication: Beijing, China : Baishideng |
| مستخلص: | Aim: To evaluate the effect of a 6 and 12 mo lifestyle modification intervention in nonalcoholic fatty liver diseases (NAFLD) in Chengyang District of Qingdao. Methods: Participants with NAFLD who had resided in Chengyang District for more than 5 years were enrolled in this study. After the 6 and 12 mo lifestyle modification intervention based on physical activity, nutrition and behavior therapy, parameters such as body weight, body mass index (BMI), waist circumference, serum alanine aminotransferase (ALT), aspartate aminotransferase values, serum cholesterol, triglycerides, fasting glucose, fasting insulin and visceral fat area (VFA), the liver-spleen ratio and the homeostasis model assessment of insulin resistance (HOMA-IR) were evaluated and compared between participants with and without the intervention. Results: Seven hundred and twenty-four participants were assigned to the lifestyle intervention group (LS) and 363 participants were assigned to the control group (CON). After the intervention, body weights in the LS group were significantly decreased compared to those in the CON group at 6 mo (11.59% ± 4.7% vs 0.4% ± 0.2%, P = 0.001) and at 12 mo (12.73% ± 5.6% vs 0.9% ± 0.3%, P = 0.001). Compared with the CON group, BMI was more decreased in the LS group after 6 and 12 mo (P = 0.043 and P = 0.032). Waist circumference was more reduced in the LS group than in CON (P = 0.031 and P = 0.017). After the 6 and 12 mo intervention, ALT decreased significantly in the LS group (P = 0.003 and P = 0.002). After 6 and 12 mo, the metabolic syndrome rate had decreased more in the LS group compared with the CON group (P = 0.026 and P = 0.017). After 12 mo, the HOMA-IR score decreased more obviously in the LS group (P = 0.041); this result also appeared in the VFA after 12 mo in the LS group (P = 0.035). Conclusion: Lifestyle intervention was effective in improving NAFLD in both 6 and 12 mo interventions. This intervention offered a practical approach for treating a large number of NAFLD patients in the Chengyang District of Qingdao. |
| References: | J Gastroenterol. 2009;44(12):1203-8. (PMID: 19728009) Med Sci Sports Exerc. 2000 Sep;32(9 Suppl):S498-504. (PMID: 10993420) Gastroenterology. 2001 Apr;120(5):1183-92. (PMID: 11266382) Appl Physiol Nutr Metab. 2008 Aug;33(4):802-7. (PMID: 18641726) Appl Human Sci. 1998 Nov;17(6):281-8. (PMID: 10052227) Eur J Gastroenterol Hepatol. 2006 Dec;18(12):1241-5. (PMID: 17099371) J Gastroenterol. 2012 Jan;47(1):29-36. (PMID: 21983927) Sci Am. 2002 Feb;286(2):74-80. (PMID: 11828703) Hepatology. 2010 Jan;51(1):121-9. (PMID: 19827166) J Hepatol. 2005 Sep;43(3):508-14. (PMID: 16006003) Gastroenterology. 2002 Sep;123(3):745-50. (PMID: 12198701) Diabetologia. 1985 Jul;28(7):412-9. (PMID: 3899825) Front Biosci (Elite Ed). 2012 Jan 01;4:1015-23. (PMID: 22201932) Drugs Today (Barc). 2011 Dec;47(12):915-22. (PMID: 22348916) Curr Opin Clin Nutr Metab Care. 2012 Jul;15(4):350-6. (PMID: 22617561) Lancet. 2005 Sep 24-30;366(9491):1059-62. (PMID: 16182882) Arch Dis Child. 2009 Jun;94(6):437-42. (PMID: 19224892) World J Gastroenterol. 2011 Aug 7;17(29):3377-89. (PMID: 21876630) World J Gastroenterol. 2007 Dec 21;13(47):6419-24. (PMID: 18081233) Diabetes Care. 2007 Nov;30(11):2940-4. (PMID: 17666460) Diabetes Care. 2007 May;30(5):1212-8. (PMID: 17277038) |
| فهرسة مساهمة: | Keywords: Lifestyle intervention; Non-alcoholic fatty liver disease; Obese |
| تواريخ الأحداث: | Date Created: 20120803 Date Completed: 20121002 Latest Revision: 20211021 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC3409357 |
| DOI: | 10.4254/wjh.v4.i7.224 |
| PMID: | 22855698 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1948-5182 |
|---|---|
| DOI: | 10.4254/wjh.v4.i7.224 |