دورية أكاديمية
أعرض في EDS

Longitudinal MRI study on the natural history of carotid artery plaques in symptomatic patients.

التفاصيل البيبلوغرافية
العنوان: Longitudinal MRI study on the natural history of carotid artery plaques in symptomatic patients.
المؤلفون: Kwee RM; Department of Radiology, Maastricht University Medical Center, Maastricht, The Netherlands. rmkwee@gmail.com, Truijman MT, van Oostenbrugge RJ, Mess WH, Prins MH, Franke CL, Korten AG, Wildberger JE, Kooi ME
المصدر: PloS one [PLoS One] 2012; Vol. 7 (7), pp. e42472. Date of Electronic Publication: 2012 Jul 31.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Atherosclerosis/*pathology , Carotid Arteries/*pathology , Magnetic Resonance Imaging/*methods, Aged ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged
مستخلص: Purpose: To investigate the natural history of carotid atherosclerosis in patients who experienced a TIA or ischemic stroke.
Patients and Methods: Ninety-two TIA/stroke patients (57 men, mean age 67.7 ± 9.8 years) with ipsilateral <70% carotid stenosis underwent multisequence MRI of the plaque ipsilateral to the symptomatic side at baseline and after one year. For each plaque, several parameters were assessed at both time points.
Results: Carotid lumen, wall and total vessel ( = carotid lumen and wall) volume did not significantly change. Forty-four patients had a plaque with a lipid-rich necrotic core (LRNC) at baseline, of which 34 also had a LRNC after one year. In three patients a LRNC appeared after one year. Thirty patients had a plaque with a thin and/or ruptured fibrous cap (FC) at both time points. In seven patients, FC status changed from thin and/or ruptured into thick and intact. In three patients, FC status changed from thick and intact into thin and/or ruptured. Twenty patients had intraplaque hemorrhage (IPH) at both time points. In four patients, IPH disappeared, whereas in three patients, new IPH appeared at follow-up.
Conclusion: In TIA/stroke patients, carotid plaque morphology does not significantly change over a one-year period. IPH and FC status change in a minority of patients.
References: JAMA. 2004 Oct 20;292(15):1845-52. (PMID: 15494582)
Circulation. 2006 May 16;113(19):2320-8. (PMID: 16651471)
JACC Cardiovasc Imaging. 2011 Sep;4(9):977-86. (PMID: 21920335)
J Magn Reson Imaging. 2004 Jul;20(1):105-10. (PMID: 15221815)
Lancet. 2004 Mar 20;363(9413):915-24. (PMID: 15043958)
Radiology. 2003 Nov;229(2):340-6. (PMID: 14500855)
Stroke. 2009 Sep;40(9):3017-21. (PMID: 19556528)
J Magn Reson Imaging. 2008 Jun;27(6):1356-61. (PMID: 18504755)
JACC Cardiovasc Imaging. 2009 Dec;2(12):1381-9. (PMID: 20083072)
Stroke. 2010 Jul;41(7):1389-93. (PMID: 20466996)
Atherosclerosis. 2007 Oct;194(2):e34-42. (PMID: 16978632)
Radiology. 2006 Aug;240(2):464-72. (PMID: 16864672)
JAMA. 1995 May 10;273(18):1421-8. (PMID: 7723155)
Invest Radiol. 2010 Dec;45(12):803-9. (PMID: 20829705)
Lancet. 2003 Jan 11;361(9352):107-16. (PMID: 12531577)
Radiology. 2009 Sep;252(3):789-96. (PMID: 19508991)
Circulation. 2005 Nov 29;112(22):3437-44. (PMID: 16301346)
Circ J. 2009 Oct;73(10):1765-73. (PMID: 19755748)
Arterioscler Thromb Vasc Biol. 2005 Jan;25(1):234-9. (PMID: 15528475)
J Vasc Surg. 2008 Jul;48(1):104-12; discussion 112-3. (PMID: 18486416)
تواريخ الأحداث: Date Created: 20120804 Date Completed: 20130114 Latest Revision: 20211021
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC3409172
DOI: 10.1371/journal.pone.0042472
PMID: 22860130
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0042472