دورية أكاديمية
أعرض في EDS

Genetic, environmental and stochastic factors in monozygotic twin discordance with a focus on epigenetic differences.

التفاصيل البيبلوغرافية
العنوان: Genetic, environmental and stochastic factors in monozygotic twin discordance with a focus on epigenetic differences.
المؤلفون: Czyz W; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Morahan JM, Ebers GC, Ramagopalan SV
المصدر: BMC medicine [BMC Med] 2012 Aug 17; Vol. 10, pp. 93. Date of Electronic Publication: 2012 Aug 17.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, 2003-
مواضيع طبية MeSH: Epigenesis, Genetic* , Gene-Environment Interaction*, Twins, Monozygotic/*genetics, DNA Methylation ; Diseases in Twins/genetics ; Fetus ; Humans ; Stochastic Processes
مستخلص: Genetic-epidemiological studies on monozygotic (MZ) twins have been used for decades to tease out the relative contributions of genes and the environment to a trait. Phenotypic discordance in MZ twins has traditionally been ascribed to non-shared environmental factors acting after birth, however recent data indicate that this explanation is far too simple. In this paper, we review other reasons for discordance, including differences in the in utero environment, genetic mosaicism, and stochastic factors, focusing particularly on epigenetic discordance. Epigenetic differences are gaining increasing recognition. Although it is clear that in specific cases epigenetic alterations provide a causal factor in disease etiology, the overall significance of epigenetics in twin discordance remains unclear. It is also challenging to determine the causality and relative contributions of environmental, genetic, and stochastic factors to epigenetic variability. Epigenomic profiling studies have recently shed more light on the dynamics of temporal methylation change and methylome heritability, yet have not given a definite answer regarding their relevance to disease, because of limitations in establishing causality. Here, we explore the subject of epigenetics as another component in human phenotypic variability and its links to disease focusing particularly on evidence from MZ twin studies.
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تواريخ الأحداث: Date Created: 20120818 Date Completed: 20130603 Latest Revision: 20240318
رمز التحديث: 20240318
مُعرف محوري في PubMed: PMC3566971
DOI: 10.1186/1741-7015-10-93
PMID: 22898292
قاعدة البيانات: MEDLINE
الوصف
تدمد:1741-7015
DOI:10.1186/1741-7015-10-93