دورية أكاديمية
Genetic, environmental and stochastic factors in monozygotic twin discordance with a focus on epigenetic differences.
العنوان: | Genetic, environmental and stochastic factors in monozygotic twin discordance with a focus on epigenetic differences. |
---|---|
المؤلفون: | Czyz W; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Morahan JM, Ebers GC, Ramagopalan SV |
المصدر: | BMC medicine [BMC Med] 2012 Aug 17; Vol. 10, pp. 93. Date of Electronic Publication: 2012 Aug 17. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [London] : BioMed Central, 2003- |
مواضيع طبية MeSH: | Epigenesis, Genetic* , Gene-Environment Interaction*, Twins, Monozygotic/*genetics, DNA Methylation ; Diseases in Twins/genetics ; Fetus ; Humans ; Stochastic Processes |
مستخلص: | Genetic-epidemiological studies on monozygotic (MZ) twins have been used for decades to tease out the relative contributions of genes and the environment to a trait. Phenotypic discordance in MZ twins has traditionally been ascribed to non-shared environmental factors acting after birth, however recent data indicate that this explanation is far too simple. In this paper, we review other reasons for discordance, including differences in the in utero environment, genetic mosaicism, and stochastic factors, focusing particularly on epigenetic discordance. Epigenetic differences are gaining increasing recognition. Although it is clear that in specific cases epigenetic alterations provide a causal factor in disease etiology, the overall significance of epigenetics in twin discordance remains unclear. It is also challenging to determine the causality and relative contributions of environmental, genetic, and stochastic factors to epigenetic variability. Epigenomic profiling studies have recently shed more light on the dynamics of temporal methylation change and methylome heritability, yet have not given a definite answer regarding their relevance to disease, because of limitations in establishing causality. Here, we explore the subject of epigenetics as another component in human phenotypic variability and its links to disease focusing particularly on evidence from MZ twin studies. |
References: | Annu Rev Genomics Hum Genet. 2004;5:479-510. (PMID: 15485357) Cell. 1996 Oct 18;87(2):159-70. (PMID: 8861899) Lab Anim. 1990 Jan;24(1):71-7. (PMID: 2406501) Twin Res Hum Genet. 2010 Dec;13(6):582-94. (PMID: 21142935) Am J Med Genet B Neuropsychiatr Genet. 2006 Jun 5;141B(4):421-5. (PMID: 16583437) Early Hum Dev. 2001 Sep;64(2):105-17. (PMID: 11440823) Hum Mol Genet. 2010 Nov 1;19(21):4176-88. (PMID: 20699328) Am J Obstet Gynecol. 2002 Mar;186(3):579-83. (PMID: 11904627) Am J Obstet Gynecol. 2001 Sep;185(3):708-15. (PMID: 11568802) Am J Obstet Gynecol. 2001 Nov;185(5):1239-46. (PMID: 11717663) PLoS One. 2009 Aug 12;4(8):e6617. (PMID: 19672297) Hum Mol Genet. 2011 Dec 15;20(24):4786-96. (PMID: 21908516) PLoS Genet. 2012 Jan;8(1):e1002454. (PMID: 22291603) Clin Genet. 2011 Jun;79(6):546-53. (PMID: 20618351) Nature. 2010 Oct 28;467(7319):1061-73. (PMID: 20981092) Nat Rev Genet. 2005 Jun;6(6):451-64. (PMID: 15883588) Twin Res Hum Genet. 2010 Oct;13(5):455-60. (PMID: 20874467) Mutat Res. 2010 Oct;705(2):96-106. (PMID: 20399892) Cytogenet Genome Res. 2008;123(1-4):270-7. (PMID: 19287164) Am J Med Genet. 1999 Sep 17;86(3):269-73. (PMID: 10482878) Trends Genet. 2004 Nov;20(11):550-4. (PMID: 15475114) Nat Rev Genet. 2002 Oct;3(10):748-58. (PMID: 12360233) Heart. 2002 Sep;88(3):271-7. (PMID: 12181221) Nucleic Acids Res. 2002 Apr 1;30(7):e28. (PMID: 11917034) Acta Genet Med Gemellol (Roma). 1995;44(1):11-23. (PMID: 7653200) Science. 1990 Oct 12;250(4978):223-8. (PMID: 2218526) Am J Med Genet A. 2010 Mar;152A(3):601-6. (PMID: 20186797) Clin Genet. 2002 Aug;62(2):97-103. (PMID: 12220446) Mutat Res. 2003 Mar;543(2):125-36. (PMID: 12644182) J Obstet Gynaecol. 2006 May;26(4):291-6. (PMID: 16753674) PLoS Genet. 2011 Sep;7(9):e1002300. (PMID: 21980303) Genome Res. 2010 Dec;20(12):1623-8. (PMID: 21041414) Drug Saf. 2008;31(1):21-37. (PMID: 18095744) Biochem Cell Biol. 2005 Jun;83(3):296-321. (PMID: 15959557) PLoS One. 2009 Aug 26;4(8):e6767. (PMID: 19774229) J Neurobiol. 2003 Jan;54(1):4-45. (PMID: 12486697) FASEB J. 2010 Aug;24(8):3036-51. (PMID: 20375269) Stroke. 2005 Sep;36(9):2027-31. (PMID: 16051898) Curr Opin Genet Dev. 2008 Jun;18(3):229-34. (PMID: 18674616) Science. 2008 Apr 4;320(5872):65-8. (PMID: 18388284) Cell Mol Life Sci. 2009 Jul;66(14):2249-61. (PMID: 19326048) Fetal Diagn Ther. 2009;25(1):31-5. (PMID: 19153494) J Child Neurol. 1999 Oct;14(10):649-54; discussion 669-72 discussio. (PMID: 10511337) N Engl J Med. 2006 Jun 22;354(25):2677-88. (PMID: 16790700) Am J Med Genet. 1998 Jul 24;78(4):319-21. (PMID: 9714432) Int J Epidemiol. 2012 Feb;41(1):74-8. (PMID: 22269254) Trends Genet. 2006 Jul;22(7):347-50. (PMID: 16697072) Biol Lett. 2009 Oct 23;5(5):663-6. (PMID: 19493877) Aging Cell. 2012 Aug;11(4):694-703. (PMID: 22621408) Hum Mol Genet. 2002 May 15;11(11):1317-25. (PMID: 12019213) J Clin Endocrinol Metab. 2002 Oct;87(10):4438-41. (PMID: 12364414) Nat Rev Genet. 2011 Jul 12;12(8):529-41. (PMID: 21747404) Genome Res. 2010 Nov;20(11):1469-81. (PMID: 20841430) Environ Mol Mutagen. 2011 Jan;52(1):1-11. (PMID: 20839222) Nature. 2008 Dec 11;456(7223):728-31. (PMID: 19079049) Nat Rev Genet. 2002 Nov;3(11):872-82. (PMID: 12415317) Mol Psychiatry. 2005 Jul;10(7):622-30. (PMID: 15838537) Genome Res. 2010 Apr;20(4):434-9. (PMID: 20219945) Genome Res. 2003 Aug;13(8):1855-62. (PMID: 12902379) Nat Genet. 2006 Jun;38(6):663-7. (PMID: 16715096) Nature. 2009 Nov 19;462(7271):315-22. (PMID: 19829295) Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10604-9. (PMID: 16009939) J Med Genet. 2003 Oct;40(10):721-8. (PMID: 14569115) Am J Med Genet C Semin Med Genet. 2009 May 15;151C(2):110-27. (PMID: 19363805) Nat Genet. 2009 Feb;41(2):240-5. (PMID: 19151718) Acta Genet Med Gemellol (Roma). 1988;37(3-4):229-38. (PMID: 3254015) Obesity (Silver Spring). 2011 Jul;19(7):1519-22. (PMID: 21273997) Science. 2007 Nov 16;318(5853):1136-40. (PMID: 18006746) Cancer Causes Control. 1995 Nov;6(6):519-24. (PMID: 8580300) PLoS One. 2010 Nov 04;5(11):e13843. (PMID: 21079792) J Pediatr. 1979 Dec;95(6):921-30. (PMID: 501497) Int J Epidemiol. 2012 Feb;41(1):140-50. (PMID: 22253312) Hum Mol Genet. 2005 Apr 15;14 Spec No 1:R11-8. (PMID: 15809262) Nat Rev Genet. 2005 Feb;6(2):95-108. (PMID: 15716906) Trends Genet. 2011 Mar;27(3):116-25. (PMID: 21257220) Nature. 2010 Jun 10;465(7299):721-7. (PMID: 20535201) Nat Genet. 2003 Mar;33 Suppl:245-54. (PMID: 12610534) Am J Hum Genet. 2006 Jul;79(1):155-62. (PMID: 16773576) Prenat Diagn. 1997 Dec;17(13):1207-25. (PMID: 9509540) Obstet Gynecol. 2002 Sep;100(3):474-80. (PMID: 12220766) Breast Cancer Res Treat. 2010 Oct;123(3):901-5. (PMID: 20369283) Hum Mutat. 2008 Sep;29(9):1118-24. (PMID: 18570184) Int J Gynaecol Obstet. 2007 Feb;96(2):98-102. (PMID: 17250837) Annu Rev Pharmacol Toxicol. 2008;48:257-76. (PMID: 17883328) Obstet Gynecol. 1990 Feb;75(2):168-71. (PMID: 2300344) Annu Rev Genomics Hum Genet. 2008;9:233-57. (PMID: 18767965) Mol Psychiatry. 2008 Apr;13(4):429-41. (PMID: 17471289) Obstet Gynecol. 2001 Feb;97(2):310-5. (PMID: 11165601) Epigenetics. 2010 Aug 16;5(6):516-26. (PMID: 20505345) Nat Rev Genet. 2008 May;9(5):356-69. (PMID: 18398418) Am J Med Genet C Semin Med Genet. 2009 May 15;151C(2):136-41. (PMID: 19378334) Genome Res. 2010 Feb;20(2):170-9. (PMID: 20028698) J Exp Bot. 2009;60(14):3989-4002. (PMID: 19759097) Nat Rev Genet. 2010 Nov;11(11):743-4. (PMID: 20877326) Genomics. 2004 Sep;84(3):449-57. (PMID: 15498452) Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10413-4. (PMID: 16027353) Nature. 2010 Feb 18;463(7283):913-8. (PMID: 20164922) Twin Res Hum Genet. 2008 Feb;11(1):1-11. (PMID: 18251670) Am J Hum Genet. 2008 Jun;82(6):1357-60. (PMID: 18513681) Nature. 2010 Apr 29;464(7293):1351-6. (PMID: 20428171) Epigenetics. 2012 Jan 1;7(1):47-54. (PMID: 22207351) Cell. 2010 Mar 5;140(5):610-2. (PMID: 20211129) Diabetologia. 2002 Dec;45(12):1649-57. (PMID: 12488954) Epilepsia. 2004 Nov;45(11):1429-42. (PMID: 15509244) Schizophr Bull. 2003;29(1):169-78. (PMID: 12908672) Proc Natl Acad Sci U S A. 2010 Jan 26;107 Suppl 1:1725-30. (PMID: 19805033) PLoS One. 2010 Nov 15;5(11):e15393. (PMID: 21085585) Clin Rev Allergy Immunol. 2010 Aug;39(1):30-41. (PMID: 19653134) Endocrinology. 2005 Dec;146(12):5035-7. (PMID: 16291637) PLoS One. 2007 Dec 12;2(12):e1293. (PMID: 18074017) Semin Fetal Neonatal Med. 2007 Dec;12(6):439-49. (PMID: 17761462) Endocrinology. 2011 Jan;152(1):255-62. (PMID: 21084442) Trends Genet. 2001 Feb;17(2):79-82. (PMID: 11173116) Am J Hum Genet. 2008 Mar;82(3):763-71. (PMID: 18304490) |
تواريخ الأحداث: | Date Created: 20120818 Date Completed: 20130603 Latest Revision: 20240318 |
رمز التحديث: | 20240318 |
مُعرف محوري في PubMed: | PMC3566971 |
DOI: | 10.1186/1741-7015-10-93 |
PMID: | 22898292 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1741-7015 |
---|---|
DOI: | 10.1186/1741-7015-10-93 |