دورية أكاديمية
Inflammation in the carotid body during development and its contribution to apnea of prematurity.
| العنوان: | Inflammation in the carotid body during development and its contribution to apnea of prematurity. |
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| المؤلفون: | Gauda EB; Department of Pediatrics, Division of Neonatology, The Johns Hopkins School of Medicine, Baltimore, MD, USA. egauda@jhmi.edu, Shirahata M, Mason A, Pichard LE, Kostuk EW, Chavez-Valdez R |
| المصدر: | Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2013 Jan 01; Vol. 185 (1), pp. 120-31. Date of Electronic Publication: 2012 Aug 10. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 101140022 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1519 (Electronic) Linking ISSN: 15699048 NLM ISO Abbreviation: Respir Physiol Neurobiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier Science, c2002- |
| مواضيع طبية MeSH: | Apnea/*physiopathology , Carotid Body/*physiopathology , Infant, Premature, Diseases/*physiopathology , Inflammation/*physiopathology, Animals ; Apnea/etiology ; Carotid Body/growth & development ; Carotid Body/pathology ; Humans ; Hypoxia/physiopathology ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases/pathology ; Inflammation/complications |
| مستخلص: | Breathing is a complex function that is dynamic, responsive, automatic and often unstable during early development. The carotid body senses dynamic changes in arterial oxygen and carbon dioxide tension and reflexly alters ventilation and plays an essential role in terminating apnea. The carotid body contributes 10-40% to baseline ventilation in newborns and has the greatest influence on breathing in premature infants who characteristically have unstable breathing leading to apnea of prematurity. In this review, we will discuss how both excessive and minimal contributions from the carotid body destabilizes breathing in premature infants and how exposures to hypoxia or infection can lead to changes in the sensitivity of the carotid body. We propose that inflammation/infection during a critical period of carotid body development causes acute and chronic changes in the carotid body contributing to a protracted course of intractable and severe apnea known to occur in a subset of premature infants. (Copyright © 2012. Published by Elsevier B.V.) |
| تواريخ الأحداث: | Date Created: 20120821 Date Completed: 20130722 Latest Revision: 20161125 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.resp.2012.08.005 |
| PMID: | 22902305 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1878-1519 |
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| DOI: | 10.1016/j.resp.2012.08.005 |