دورية أكاديمية
أعرض في EDS

Lipocalin 2 is present in the EAE brain and is modulated by natalizumab.

التفاصيل البيبلوغرافية
العنوان: Lipocalin 2 is present in the EAE brain and is modulated by natalizumab.
المؤلفون: Marques F; School of Health Sciences, Life and Health Sciences Research Institute (ICVS), University of Minho Braga, Portugal., Mesquita SD, Sousa JC, Coppola G, Gao F, Geschwind DH, Columba-Cabezas S, Aloisi F, Degn M, Cerqueira JJ, Sousa N, Correia-Neves M, Palha JA
المصدر: Frontiers in cellular neuroscience [Front Cell Neurosci] 2012 Aug 09; Vol. 6, pp. 33. Date of Electronic Publication: 2012 Aug 09 (Print Publication: 2012).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101477935 Publication Model: eCollection Cited Medium: Internet ISSN: 1662-5102 (Electronic) Linking ISSN: 16625102 NLM ISO Abbreviation: Front Cell Neurosci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne, Switzerland : Frontiers Research Foundation, 2007-
مستخلص: Multiple sclerosis (MS) is a demyelinating disease that causes major neurological disability in young adults. A definitive diagnosis at the time of the first episode is still lacking, but since early treatment leads to better prognosis, the search for early biomarkers is needed. Here we characterized the transcriptome of the choroid plexus (CP), which is part of the blood-brain barriers (BBBs) and the major site of cerebrospinal fluid production, in the experimental autoimmune encephalomyelitis (EAE) mouse model of MS. In addition, cerebrospinal fluid samples from two cohorts of patients with MS and with optic neuritis (ON) were analyzed to confirm the clinical relevance of the findings. Genes encoding for adhesion molecules, chemokines and cytokines displayed the most altered expression, supporting the role of CP as a site of immune-brain interaction in MS. The gene encoding for lipocalin 2 was the most up-regulated; notably, the cerebrospinal fluid lipocalin 2 levels coincided with the active phases of the disease. Immunostaining revealed that neutrophils infiltrating the CP were the source of the increased lipocalin 2 expression in this structure. However, within the brain, lipocalin 2 was also detected in astrocytes, particularly in regions typically affected in patients with MS. The increase of lipocalin 2 in the cerebrospinal fluid and in astrocytes was reverted by natalizumab treatment. Most importantly, the results obtained in the murine model were translatable into humans since patients from two different cohorts presented increased cerebrospinal fluid lipocalin 2 levels. The findings support lipocalin 2 as a valuable molecule for the diagnostic/monitoring panel of MS.
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فهرسة مساهمة: Keywords: astrocytes; cerebrospinal fluid; experimental autoimmune encephalomyelitis; lipocalin 2; multiple sclerosis; natalizumab
تواريخ الأحداث: Date Created: 20120822 Date Completed: 20121002 Latest Revision: 20211021
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3414908
DOI: 10.3389/fncel.2012.00033
PMID: 22907989
قاعدة البيانات: MEDLINE
الوصف
تدمد:1662-5102
DOI:10.3389/fncel.2012.00033