دورية أكاديمية
أعرض في EDS

Immunosuppression with cyclophosphamide favors reinfection with recombinant Toxoplasma gondii strains.

التفاصيل البيبلوغرافية
العنوان: Immunosuppression with cyclophosphamide favors reinfection with recombinant Toxoplasma gondii strains.
المؤلفون: Silva LA; Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Av. Antonio Carlos 6627, 31270-901, Belo Horizonte, MG, Brazil., Brandão GP, Pinheiro BV, Vitor RW
المصدر: Parasite (Paris, France) [Parasite] 2012 Aug; Vol. 19 (3), pp. 249-57.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Princeps Editions Country of Publication: France NLM ID: 9437094 Publication Model: Print Cited Medium: Print ISSN: 1252-607X (Print) Linking ISSN: 1252607X NLM ISO Abbreviation: Parasite Subsets: MEDLINE
أسماء مطبوعة: Publication: 1995-: Issy-les-Moulineaux : Princeps Editions
Original Publication: Paris : PDG Communication, [1994-
مواضيع طبية MeSH: Immunocompromised Host*, Cyclophosphamide/*therapeutic use , Immunosuppressive Agents/*therapeutic use , Toxoplasma/*drug effects , Toxoplasmosis, Animal/*immunology, Animals ; Antibodies, Protozoan/blood ; Brain/parasitology ; Chickens ; Cyclophosphamide/pharmacology ; DNA, Protozoan/chemistry ; Disease Models, Animal ; Dogs ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Immunoglobulins/blood ; Immunosuppressive Agents/pharmacology ; Leukocyte Count ; Mice ; Mice, Inbred BALB C ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Toxoplasma/genetics ; Toxoplasma/immunology ; Toxoplasmosis, Animal/drug therapy ; Toxoplasmosis, Congenital/parasitology
مستخلص: The aim of this study was to verify the effect of immunosuppression by cyclophosphamide (Cy) on susceptibility of BALB/c mice subjected to challenge with recombinant strains of Toxoplasma gondii. Animals were prime infected with the D8 (recombinant I/III) or the ME49 (type II) non-virulent strains, weekly immunosuppressed with Cy and challenged with the CH3 or EGS virulent strains (I/III). Parasites recovered from surviving mice were submitted to PCR-RFLP analysis to confirm co-infection. Prime-infection with the D8 strain conferred more protection against challenge with the CH3 and EGS strains when compared with ME49 prime infection. Cy treatment caused significant leukopenia in the infected mice, what probably favors reinfection after challenge. Reinfection was associated with increased levels of IgA. Otherwise, Cy-treated mice presented significantly lower IgA levels after challenge, suggesting involvement of this immunoglobulin on protection against reinfection. In conclusion, BALB/c mice susceptibility to reinfection by T. gondii is related to genetic differences among the strains used for primary and challenge infections. Alteration of the host's immune integrity by Cy probably compromises the protection previously established by primary infection.
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المشرفين على المادة: 0 (Antibodies, Protozoan)
0 (DNA, Protozoan)
0 (Immunoglobulins)
0 (Immunosuppressive Agents)
8N3DW7272P (Cyclophosphamide)
تواريخ الأحداث: Date Created: 20120823 Date Completed: 20130110 Latest Revision: 20211021
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3671442
DOI: 10.1051/parasite/2012193249
PMID: 22910667
قاعدة البيانات: MEDLINE
الوصف
تدمد:1252-607X
DOI:10.1051/parasite/2012193249