دورية أكاديمية
أعرض في EDS

Expansion of HIV-specific T follicular helper cells in chronic HIV infection.

التفاصيل البيبلوغرافية
العنوان: Expansion of HIV-specific T follicular helper cells in chronic HIV infection.
المؤلفون: Lindqvist M; Ragon Institute of MGH, MIT, Boston, MA, USA., van Lunzen J, Soghoian DZ, Kuhl BD, Ranasinghe S, Kranias G, Flanders MD, Cutler S, Yudanin N, Muller MI, Davis I, Farber D, Hartjen P, Haag F, Alter G, Schulze zur Wiesch J, Streeck H
المصدر: The Journal of clinical investigation [J Clin Invest] 2012 Sep; Vol. 122 (9), pp. 3271-80. Date of Electronic Publication: 2012 Aug 27.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
أسماء مطبوعة: Publication: 1999- : Ann Arbor, MI : American Society for Clinical Investigation
Original Publication: New Haven [etc.] American Society for Clinical Investigation.
مواضيع طبية MeSH: Cell Proliferation*, HIV Infections/*immunology , HIV-1/*immunology , T-Lymphocytes, Helper-Inducer/*immunology, Anti-Retroviral Agents/pharmacology ; Anti-Retroviral Agents/therapeutic use ; B-Lymphocytes/metabolism ; Case-Control Studies ; Cells, Cultured ; Chronic Disease ; DNA-Binding Proteins/metabolism ; HIV Infections/drug therapy ; HIV Infections/pathology ; HIV-1/physiology ; Host-Pathogen Interactions ; Humans ; Immunoglobulin G/blood ; Interleukins/metabolism ; Lymph Nodes/immunology ; Lymph Nodes/pathology ; Proto-Oncogene Proteins c-bcl-6 ; Receptors, CXCR5/metabolism ; T-Lymphocytes, Helper-Inducer/metabolism ; T-Lymphocytes, Helper-Inducer/physiology ; T-Lymphocytes, Helper-Inducer/virology ; Viremia/virology
مستخلص: HIV targets CD4 T cells, which are required for the induction of high-affinity antibody responses and the formation of long-lived B cell memory. The depletion of antigen-specific CD4 T cells during HIV infection is therefore believed to impede the development of protective B cell immunity. Although several different HIV-related B cell dysfunctions have been described, the role of CD4 T follicular helper (TFH) cells in HIV infection remains unknown. Here, we assessed HIV-specific TFH responses in the lymph nodes of treatment-naive and antiretroviral-treated HIV-infected individuals. Strikingly, both the bulk TFH and HIV-specific TFH cell populations were significantly expanded in chronic HIV infection and were highly associated with viremia. In particular, GAG-specific TFH cells were detected at significantly higher levels in the lymph nodes compared with those of GP120-specific TFH cells and showed preferential secretion of the helper cytokine IL-21. In addition, TFH cell expansion was associated with an increase of germinal center B cells and plasma cells as well as IgG1 hypersecretion. Thus, our study suggests that high levels of HIV viremia drive the expansion of TFH cells, which in turn leads to perturbations of B cell differentiation, resulting in dysregulated antibody production.
التعليقات: Comment in: J Clin Invest. 2012 Sep;122(9):3059-62. (PMID: 22922252)
References: Nat Rev Immunol. 2005 Oct;5(10):783-92. (PMID: 16200081)
Nat Med. 2011 Jul 24;17(8):983-8. (PMID: 21785430)
Nat Rev Immunol. 2009 Apr;9(4):235-45. (PMID: 19319142)
Curr Opin HIV AIDS. 2009 Sep;4(5):358-63. (PMID: 20048698)
Nat Immunol. 2006 Mar;7(3):302-10. (PMID: 16429138)
J Immunol. 2004 Nov 1;173(9):5361-71. (PMID: 15494482)
J Immunol. 1999 Aug 1;163(3):1119-22. (PMID: 10415004)
Clin Exp Immunol. 1986 Jan;63(1):234-40. (PMID: 3955884)
Science. 1986 Sep 5;233(4768):1084-6. (PMID: 3016902)
J Exp Med. 1994 Jul 1;180(1):329-39. (PMID: 8006591)
Sci Transl Med. 2012 Feb 29;4(123):123ra25. (PMID: 22378925)
Immunity. 2008 Jun;28(6):847-58. (PMID: 18549802)
J Exp Med. 1998 Jul 20;188(2):233-45. (PMID: 9670036)
J Virol. 1997 Apr;71(4):2799-809. (PMID: 9060635)
J Exp Med. 2000 Sep 4;192(5):637-46. (PMID: 10974030)
Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14807-12. (PMID: 16199516)
Clin Exp Immunol. 1989 Nov;78(2):153-8. (PMID: 12412741)
Nature. 2002 May 2;417(6884):95-8. (PMID: 11986671)
J Immunol. 2005 Dec 15;175(12):7867-79. (PMID: 16339522)
Annu Rev Immunol. 2011;29:621-63. (PMID: 21314428)
J Immunol. 2012 Apr 15;188(8):3734-44. (PMID: 22427637)
J Immunol. 2007 Nov 1;179(9):5886-96. (PMID: 17947662)
Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2262-7. (PMID: 16461915)
J Exp Med. 2004 Sep 20;200(6):749-59. (PMID: 15365096)
Nature. 2005 Apr 28;434(7037):1093-7. (PMID: 15793563)
J Clin Invest. 2012 Sep;122(9):3281-94. (PMID: 22922258)
J Virol. 2009 Jan;83(2):1045-59. (PMID: 19004942)
J Immunol. 2007 Dec 15;179(12):8180-90. (PMID: 18056361)
Blood. 2007 Mar 1;109(5):2086-8. (PMID: 17053062)
J Virol. 2010 Aug;84(16):8098-110. (PMID: 20538861)
Arthritis Rheum. 2010 Jan;62(1):234-44. (PMID: 20039395)
Immunity. 2009 Sep 18;31(3):457-68. (PMID: 19631565)
J Immunol. 2011 Sep 1;187(5):2089-92. (PMID: 21804014)
Curr Opin HIV AIDS. 2008 Sep;3(5):541-7. (PMID: 19373019)
AIDS. 2005 Nov 18;19(17):1947-55. (PMID: 16260900)
Nat Immunol. 2009 Apr;10(4):375-84. (PMID: 19252493)
Virology. 2010 Feb 5;397(1):7-13. (PMID: 19962720)
J Clin Invest. 2005 Nov;115(11):3205-16. (PMID: 16211091)
Nat Rev Immunol. 2011 Dec 09;12(1):24-34. (PMID: 22158414)
J Exp Med. 2010 Feb 15;207(2):353-63. (PMID: 20142429)
J Exp Med. 2011 May 9;208(5):987-99. (PMID: 21536743)
J Exp Med. 1998 Mar 16;187(6):949-59. (PMID: 9500797)
J Virol. 2011 Jan;85(2):733-41. (PMID: 21047960)
AIDS Res Hum Retroviruses. 2012 Jan;28(1):1-15. (PMID: 21495876)
Science. 2010 Aug 13;329(5993):811-7. (PMID: 20616231)
J Immunol. 2004 Jul 1;173(1):68-78. (PMID: 15210760)
J Virol. 2010 Feb;84(3):1631-6. (PMID: 19923174)
Nat Med. 2011 Jul 24;17(8):975-82. (PMID: 21785433)
Ann Biol Clin (Paris). 1994;52(7-8):561-7. (PMID: 7840433)
J Virol. 2008 Dec;82(23):11651-68. (PMID: 18815292)
Blood. 2004 Mar 15;103(6):2180-6. (PMID: 14604962)
معلومات مُعتمدة: R01 AI091450 United States AI NIAID NIH HHS; R01 AI094602 United States AI NIAID NIH HHS; 1R01-AI094602-01 United States AI NIAID NIH HHS; 1R01-AI091450-01 United States AI NIAID NIH HHS
المشرفين على المادة: 0 (Anti-Retroviral Agents)
0 (BCL6 protein, human)
0 (CXCR5 protein, human)
0 (DNA-Binding Proteins)
0 (Immunoglobulin G)
0 (Interleukins)
0 (Proto-Oncogene Proteins c-bcl-6)
0 (Receptors, CXCR5)
MKM3CA6LT1 (interleukin-21)
تواريخ الأحداث: Date Created: 20120828 Date Completed: 20121119 Latest Revision: 20211021
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC3428098
DOI: 10.1172/JCI64314
PMID: 22922259
قاعدة البيانات: MEDLINE
الوصف
تدمد:1558-8238
DOI:10.1172/JCI64314