دورية أكاديمية
Expansion of HIV-specific T follicular helper cells in chronic HIV infection.
العنوان: | Expansion of HIV-specific T follicular helper cells in chronic HIV infection. |
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المؤلفون: | Lindqvist M; Ragon Institute of MGH, MIT, Boston, MA, USA., van Lunzen J, Soghoian DZ, Kuhl BD, Ranasinghe S, Kranias G, Flanders MD, Cutler S, Yudanin N, Muller MI, Davis I, Farber D, Hartjen P, Haag F, Alter G, Schulze zur Wiesch J, Streeck H |
المصدر: | The Journal of clinical investigation [J Clin Invest] 2012 Sep; Vol. 122 (9), pp. 3271-80. Date of Electronic Publication: 2012 Aug 27. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 1999- : Ann Arbor, MI : American Society for Clinical Investigation Original Publication: New Haven [etc.] American Society for Clinical Investigation. |
مواضيع طبية MeSH: | Cell Proliferation*, HIV Infections/*immunology , HIV-1/*immunology , T-Lymphocytes, Helper-Inducer/*immunology, Anti-Retroviral Agents/pharmacology ; Anti-Retroviral Agents/therapeutic use ; B-Lymphocytes/metabolism ; Case-Control Studies ; Cells, Cultured ; Chronic Disease ; DNA-Binding Proteins/metabolism ; HIV Infections/drug therapy ; HIV Infections/pathology ; HIV-1/physiology ; Host-Pathogen Interactions ; Humans ; Immunoglobulin G/blood ; Interleukins/metabolism ; Lymph Nodes/immunology ; Lymph Nodes/pathology ; Proto-Oncogene Proteins c-bcl-6 ; Receptors, CXCR5/metabolism ; T-Lymphocytes, Helper-Inducer/metabolism ; T-Lymphocytes, Helper-Inducer/physiology ; T-Lymphocytes, Helper-Inducer/virology ; Viremia/virology |
مستخلص: | HIV targets CD4 T cells, which are required for the induction of high-affinity antibody responses and the formation of long-lived B cell memory. The depletion of antigen-specific CD4 T cells during HIV infection is therefore believed to impede the development of protective B cell immunity. Although several different HIV-related B cell dysfunctions have been described, the role of CD4 T follicular helper (TFH) cells in HIV infection remains unknown. Here, we assessed HIV-specific TFH responses in the lymph nodes of treatment-naive and antiretroviral-treated HIV-infected individuals. Strikingly, both the bulk TFH and HIV-specific TFH cell populations were significantly expanded in chronic HIV infection and were highly associated with viremia. In particular, GAG-specific TFH cells were detected at significantly higher levels in the lymph nodes compared with those of GP120-specific TFH cells and showed preferential secretion of the helper cytokine IL-21. In addition, TFH cell expansion was associated with an increase of germinal center B cells and plasma cells as well as IgG1 hypersecretion. Thus, our study suggests that high levels of HIV viremia drive the expansion of TFH cells, which in turn leads to perturbations of B cell differentiation, resulting in dysregulated antibody production. |
التعليقات: | Comment in: J Clin Invest. 2012 Sep;122(9):3059-62. (PMID: 22922252) |
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معلومات مُعتمدة: | R01 AI091450 United States AI NIAID NIH HHS; R01 AI094602 United States AI NIAID NIH HHS; 1R01-AI094602-01 United States AI NIAID NIH HHS; 1R01-AI091450-01 United States AI NIAID NIH HHS |
المشرفين على المادة: | 0 (Anti-Retroviral Agents) 0 (BCL6 protein, human) 0 (CXCR5 protein, human) 0 (DNA-Binding Proteins) 0 (Immunoglobulin G) 0 (Interleukins) 0 (Proto-Oncogene Proteins c-bcl-6) 0 (Receptors, CXCR5) MKM3CA6LT1 (interleukin-21) |
تواريخ الأحداث: | Date Created: 20120828 Date Completed: 20121119 Latest Revision: 20211021 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC3428098 |
DOI: | 10.1172/JCI64314 |
PMID: | 22922259 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1558-8238 |
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DOI: | 10.1172/JCI64314 |