دورية أكاديمية
Reversible pulmonary trunk banding: VII. Stress echocardiographic assessment of rapid ventricular hypertrophy in young goats.
| العنوان: | Reversible pulmonary trunk banding: VII. Stress echocardiographic assessment of rapid ventricular hypertrophy in young goats. |
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| المؤلفون: | Fávaro GA; Radiology Institute, University of São Paulo Medical School, São Paulo, Brazil. guzfavaro@hotmail.com, Assad RS, Abduch MC, Silva GJ, Gomes GS, Andrade JL, Krieger JE, Moreira LF |
| المصدر: | The Journal of thoracic and cardiovascular surgery [J Thorac Cardiovasc Surg] 2013 May; Vol. 145 (5), pp. 1345-1351.e4. Date of Electronic Publication: 2012 Aug 24. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mosby Country of Publication: United States NLM ID: 0376343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-685X (Electronic) Linking ISSN: 00225223 NLM ISO Abbreviation: J Thorac Cardiovasc Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: St. Louis, MO : Mosby Original Publication: St. Louis. |
| مواضيع طبية MeSH: | Echocardiography, Stress*, Hypertrophy, Right Ventricular/*diagnostic imaging , Pulmonary Artery/*surgery, Animals ; Constriction ; Disease Models, Animal ; Edema, Cardiac/diagnostic imaging ; Edema, Cardiac/etiology ; Goats ; Hemodynamics ; Hypertrophy, Right Ventricular/etiology ; Hypertrophy, Right Ventricular/physiopathology ; Myocardial Contraction ; Pulmonary Artery/physiopathology ; Time Factors ; Ventricular Function, Right ; Ventricular Pressure |
| مستخلص: | Background: Ventricle retraining with abrupt systolic overload can cause myocardial edema and necrosis, followed by late ventricular failure. Intermittent systolic overload could minimize the inadequacy of conventional pulmonary artery banding. The present study compared ventricle function under dobutamine stress in 2 protocols of systolic overload in young goats. Methods: Nineteen young goats were divided into 3 groups: sham (n = 7; no systolic pressure overload), continuous (n = 6; systolic overload maintained for 96 hours), and intermittent (n = 6; 4 periods of 12-hour systolic overload, paired with a 12-hour resting period). Echocardiographic and hemodynamic evaluations were performed daily. The myocardial performance index and ejection fraction were evaluated at rest and during dobutamine stress. The goats were then killed for morphologic evaluation. Results: The intermittent group underwent less systolic overload than the continuous group (P < .05). Nevertheless, both groups had increased right ventricular and septal masses compared with the sham group (P < .0002). Echocardiography revealed a major increase in right ventricular wall thickness in the intermittent group (+64.8% ± 23.37%) compared with the continuous group (+43.9% ± 19.26%; P = .015). Only the continuous group remained with significant right ventricular dilation throughout the protocol (P < .001). The intermittent group had a significantly better myocardial performance index at the end of the protocol, under resting and dobutamine infusion, compared with the continuous group (P < .012). Conclusions: Both systolic overload protocols have induced rapid right ventricular hypertrophy. However, only the intermittent group had better preservation of right ventricular function at the end of the protocol, both at rest and during dobutamine infusion. (Copyright © 2013 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.) |
| تواريخ الأحداث: | Date Created: 20120829 Date Completed: 20130617 Latest Revision: 20161125 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.jtcvs.2012.07.068 |
| PMID: | 22925567 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1097-685X |
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| DOI: | 10.1016/j.jtcvs.2012.07.068 |