دورية أكاديمية
The microalga Spirulina platensis presents anti-inflammatory action as well as hypoglycemic and hypolipidemic properties in diabetic rats.
| العنوان: | The microalga Spirulina platensis presents anti-inflammatory action as well as hypoglycemic and hypolipidemic properties in diabetic rats. |
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| المؤلفون: | Joventino IP; G&F Spirulina do Brasil M.E., Alves HG, Neves LC, Pinheiro-Joventino F, Leal LK, Neves SA, Ferreira FV, Brito GA, Viana GB |
| المصدر: | Journal of complementary & integrative medicine [J Complement Integr Med] 2012 Aug 10; Vol. 9, pp. Article 17. Date of Electronic Publication: 2012 Aug 10. |
| نوع المنشور: | Evaluation Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Walter de Gruyter Country of Publication: Germany NLM ID: 101313855 Publication Model: Electronic Cited Medium: Internet ISSN: 1553-3840 (Electronic) Linking ISSN: 15533840 NLM ISO Abbreviation: J Complement Integr Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2012-> : Berlin : Walter de Gruyter Original Publication: Berkeley, Calif. : Berkeley Electronic Press, 2004- |
| مواضيع طبية MeSH: | Spirulina*, Anti-Inflammatory Agents/*therapeutic use , Biological Products/*therapeutic use , Diabetes Mellitus, Experimental/*drug therapy , Hypoglycemic Agents/*therapeutic use , Hypolipidemic Agents/*therapeutic use, Administration, Oral ; Alloxan ; Animals ; Anti-Inflammatory Agents/pharmacology ; Biological Products/pharmacology ; Biomarkers/metabolism ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Carrageenan ; Cells, Cultured ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Experimental/chemically induced ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Edema/chemically induced ; Edema/drug therapy ; Edema/metabolism ; Humans ; Hypoglycemic Agents/pharmacology ; Hypolipidemic Agents/pharmacology ; Lipid Metabolism/drug effects ; Male ; Mice ; Neutrophils/drug effects ; Neutrophils/enzymology ; Pancreas/drug effects ; Pancreas/metabolism ; Peroxidase/metabolism ; Rats ; Rats, Wistar ; Skin Diseases/chemically induced ; Skin Diseases/drug therapy ; Skin Diseases/metabolism ; Tumor Necrosis Factor-alpha/metabolism |
| مستخلص: | Spirulina platensis (Spi) is a microalga presenting high contents of proteins, γ-linolenic acid, vitamins and minerals, and showing many biological activities. It is a promising drug for the treatment of diseases including diabetes. The objectives of this work were to study Spi effects on alloxan-induced diabetic rats, and associate this to its anti-inflammatory activity. The treatment with Spi (25, 50 or 100 mg/kg, p.o.) started 48 h after the alloxan injection, continuing for 5 or 10 days. Biochemical parameters were measured in sera of treated and untreated animals. The anti-inflammatory activity of Spi was assessed by the formalin test and carrageenan-induced paw edema in mice. Immunostainings for TNF-alpha were carried out in the carrageenan-induced paw edema in rats, before and after the Spi treatment, and its effect on the release of myeloperoxidase from human neutrophils was also determined. Spi decreased glycemia as well as triglyceride and total cholesterol levels of diabetic rats. Levels of urea and creatinine were also reduced, while liver transaminases were unaltered. Spi also decreased dose-dependently the 1st (neurogenic) and mainly the 2nd phase (inflammatory) of the formalin test, as well as the carrageenan-induced paw edema in mice. The anti-inflammatory effect of Spi was further confirmed by decreases in TNF-alpha immunostaining in the inflamed paw and in the myeloperoxidase release from human neutrophils. The results showed that the anti-diabetic effect of S. platensis is already manifested after a 5-day treatment. Additionally, considering the relationship between diabetes and inflammation, the microalga anti-inflammatory action may also be involved. |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents) 0 (Biological Products) 0 (Biomarkers) 0 (Blood Glucose) 0 (Hypoglycemic Agents) 0 (Hypolipidemic Agents) 0 (Tumor Necrosis Factor-alpha) 6SW5YHA5NG (Alloxan) 9000-07-1 (Carrageenan) EC 1.11.1.7 (Peroxidase) |
| تواريخ الأحداث: | Date Created: 20120905 Date Completed: 20130122 Latest Revision: 20191210 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1515/1553-3840.1534 |
| PMID: | 22944720 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1553-3840 |
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| DOI: | 10.1515/1553-3840.1534 |