دورية أكاديمية
[Effect of salvia miltiorrhiza and Ligustrazine injection on the early myocardial damage of patients with severe burn].
| العنوان: | [Effect of salvia miltiorrhiza and Ligustrazine injection on the early myocardial damage of patients with severe burn]. |
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| المؤلفون: | Ding LT; Department of Burns and Plastic Surgery, the Third Affiliated Hospital of Nantong University, Wuxi 214041, China., Zhu YG, Gu ZQ, Cai LL, Peng JL, Lü GZ |
| المصدر: | Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns [Zhonghua Shao Shang Za Zhi] 2012 Jun; Vol. 28 (3), pp. 170-2. |
| نوع المنشور: | English Abstract; Journal Article; Randomized Controlled Trial |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhonghua yi xue hui Country of Publication: China NLM ID: 100959418 Publication Model: Print Cited Medium: Print ISSN: 1009-2587 (Print) Linking ISSN: 10092587 NLM ISO Abbreviation: Zhonghua Shao Shang Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Beijing Shi : Zhonghua yi xue hui, c2000-2021. |
| مواضيع طبية MeSH: | Burns/*drug therapy , Drugs, Chinese Herbal/*therapeutic use , Myocardium/*pathology , Pyrazines/*therapeutic use, Adolescent ; Adult ; Burns/blood ; Creatine Kinase, MB Form/blood ; Female ; Humans ; Male ; Middle Aged ; Salvia miltiorrhiza ; Troponin I/blood ; Young Adult |
| مستخلص: | Objective: To observe the effect of salvia miltiorrhiza and ligustrazine injection on the early myocardial damage of severely burned patients. Methods: Twenty severely burned patients hospitalized from January 2010 to August 2011, with burn area equal to or more than 50% TBSA, were divided into two groups following hospitalization sequence, with odd number patients entering treatment group (T, n = 10) and even number patients entering control group (C, n = 10). Patients in C group were treated with routine methods, including fluid resuscitation based on the Third Military Medical University formula, anti-infection treatment, support treatment, and organ-protection treatment, etc. In addition to routine treatment methods, patients in T group received intravenous infusion of 250 mL glucose injection (50 g/L) containing 10 mL salvia miltiorrhiza and ligustrazine concoction, once a day, and continued for three days. Venous blood of patients was drawn at post burn hour (PBH) 12, 24, 48, and 72 to determine the plasma levels of cardiac troponin I (cTnI), creatine kinase isozyme MB (CK-MB), and atrial natriuretic peptide (ANP). Data were processed with t test. Results: At each time point, levels of cTnI, CK-MB, and ANP were lower in T group than in C group. Differences in contents of these parameters between two groups were statistically significant at most time points, with t values from 2.136 to 2.918, P < 0.05 or P < 0.01. Plasma levels of cTnI, CK-MB, and ANP in both groups peaked at PBH 12, which were respectively (28 ± 10) ng/mL, (76 ± 13) U/L, (430 ± 87) pg/mL in T group, and (38 ± 11) ng/mL, (87 ± 10) U/L, (453 ± 91) pg/mL in C group. From PBH 24 to 72, contents of above-mentioned parameters decreased gradually in both groups. Conclusions: Early use of salvia miltiorrhiza and ligustrazine injection in severely burned patients can effectively reduce myocardial damage, thus protect the myocardium from injury. |
| المشرفين على المادة: | 0 (Drugs, Chinese Herbal) 0 (Pyrazines) 0 (Troponin I) EC 2.7.3.2 (Creatine Kinase, MB Form) V80F4IA5XG (tetramethylpyrazine) |
| تواريخ الأحداث: | Date Created: 20120913 Date Completed: 20130620 Latest Revision: 20120912 |
| رمز التحديث: | 20221213 |
| PMID: | 22967970 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1009-2587 |
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