دورية أكاديمية
أعرض في EDS

Extradenticle and homothorax control adult muscle fiber identity in Drosophila.

التفاصيل البيبلوغرافية
العنوان: Extradenticle and homothorax control adult muscle fiber identity in Drosophila.
المؤلفون: Bryantsev AL; Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA., Duong S, Brunetti TM, Chechenova MB, Lovato TL, Nelson C, Shaw E, Uhl JD, Gebelein B, Cripps RM
المصدر: Developmental cell [Dev Cell] 2012 Sep 11; Vol. 23 (3), pp. 664-73.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101120028 Publication Model: Print Cited Medium: Internet ISSN: 1878-1551 (Electronic) Linking ISSN: 15345807 NLM ISO Abbreviation: Dev Cell Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, Mass. : Cell Press, c2001-
مواضيع طبية MeSH: Drosophila/*metabolism , Drosophila Proteins/*metabolism , Homeodomain Proteins/*metabolism , Muscle Fibers, Skeletal/*metabolism , Transcription Factors/*metabolism, Animals ; Cell Differentiation ; Drosophila/cytology ; Drosophila Proteins/genetics ; Homeodomain Proteins/genetics ; Muscle Fibers, Skeletal/cytology ; Transcription Factors/genetics
مستخلص: Here we identify a key role for the homeodomain proteins Extradenticle (Exd) and Homothorax (Hth) in the specification of muscle fiber fate in Drosophila. exd and hth are expressed in the fibrillar indirect flight muscles but not in tubular jump muscles, and manipulating exd or hth expression converts one muscle type into the other. In the flight muscles, exd and hth are genetically upstream of another muscle identity gene, salm, and are direct transcriptional regulators of the signature flight muscle structural gene, Actin88F. Exd and Hth also impact muscle identity in other somatic muscles of the body by cooperating with Hox factors. Because mammalian orthologs of exd and hth also contribute to muscle gene regulation, our studies suggest that an evolutionarily conserved genetic pathway determines muscle fiber differentiation.
(Copyright © 2012 Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: P20 GM103452 United States GM NIGMS NIH HHS; R01 GM061738 United States GM NIGMS NIH HHS; R01 GM079428 United States GM NIGMS NIH HHS; P20GM103452 United States GM NIGMS NIH HHS
المشرفين على المادة: 0 (Drosophila Proteins)
0 (Homeodomain Proteins)
0 (Transcription Factors)
0 (exd protein, Drosophila)
0 (hth protein, Drosophila)
تواريخ الأحداث: Date Created: 20120915 Date Completed: 20130108 Latest Revision: 20211021
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3575643
DOI: 10.1016/j.devcel.2012.08.004
PMID: 22975331
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-1551
DOI:10.1016/j.devcel.2012.08.004