دورية أكاديمية
Analysis of the WISP3 gene in Indian families with progressive pseudorheumatoid dysplasia.
| العنوان: | Analysis of the WISP3 gene in Indian families with progressive pseudorheumatoid dysplasia. |
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| المؤلفون: | Dalal A; Diagnostics Division, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, Andhra Pradesh, India., Bhavani G SL, Togarrati PP, Bierhals T, Nandineni MR, Danda S, Danda D, Shah H, Vijayan S, Gowrishankar K, Phadke SR, Bidchol AM, Rao AP, Nampoothiri S, Kutsche K, Girisha KM |
| المصدر: | American journal of medical genetics. Part A [Am J Med Genet A] 2012 Nov; Vol. 158A (11), pp. 2820-8. Date of Electronic Publication: 2012 Sep 17. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 101235741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4833 (Electronic) Linking ISSN: 15524825 NLM ISO Abbreviation: Am J Med Genet A Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hoboken, N.J. : Wiley-Blackwell Original Publication: Hoboken, N.J. : Wiley-Liss, c2003- |
| مواضيع طبية MeSH: | Mutation*, Arthropathy, Neurogenic/*genetics , CCN Intercellular Signaling Proteins/*genetics , White People/*genetics, Adolescent ; Adult ; Amino Acid Sequence ; Arthropathy, Neurogenic/diagnostic imaging ; Base Sequence ; CCN Intercellular Signaling Proteins/chemistry ; Child ; Child, Preschool ; Consanguinity ; Family ; Female ; Gene Order ; Humans ; India ; Infant ; Joint Diseases/congenital ; Male ; Middle Aged ; Molecular Sequence Data ; Pedigree ; Radiography ; Sequence Alignment ; Young Adult |
| مستخلص: | Progressive pseudorheumatoid dysplasia (PPD) is a progressive skeletal syndrome characterized by stiffness, swelling and pain in multiple joints with associated osteoporosis in affected patients. Radiographically, the predominant features resemble a spondyloepiphyseal dysplasia. Mutations in the WISP3 gene are known to cause this autosomal recessive condition. To date, only a limited number of studies have looked into the spectrum of mutations causing PPD. We report on clinical features and WISP3 mutations in a large series of Indian patients with this rare skeletal dysplasia. Families with at least one member showing clinical and radiologic features of PPD were recruited for the study. Symptoms, signs and radiographic findings were documented in 35 patients from 25 unrelated families. Swelling of small joints of hands and contractures are the most common presenting features. Mutation analysis was carried out by bidirectional sequencing of the WISP3 gene in all 35 patients. We summarize the clinical features of 35 patients with PPD and report on 11 different homozygous mutations and one instance of compound heterozygosity. Eight (c.233G>A, c.340T>C, c.348C>A, c.433T>C, c.682T>C, c.802T>G, c.947_951delAATTT, and c.1010G>A) are novel mutations and three (c.156C>A, c.248G>A, and c.739_740delTG) have been reported previously. One missense mutation (c.1010G>A; p.Cys337Tyr) appears to be the most common in our population being seen in 10 unrelated families. This is the largest cohort of patients with PPD in the literature and the first report from India on mutation analysis of WISP3. We also review all the mutations reported in WISP3 till date. (Copyright © 2012 Wiley Periodicals, Inc.) |
| المشرفين على المادة: | 0 (CCN Intercellular Signaling Proteins) 0 (CCN6 protein, human) |
| SCR Disease Name: | Arthropathy, progressive pseudorheumatoid, of childhood |
| تواريخ الأحداث: | Date Created: 20120919 Date Completed: 20130621 Latest Revision: 20221207 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1002/ajmg.a.35620 |
| PMID: | 22987568 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1552-4833 |
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| DOI: | 10.1002/ajmg.a.35620 |