دورية أكاديمية
Interclade recombination in porcine parvovirus strains.
| العنوان: | Interclade recombination in porcine parvovirus strains. |
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| المؤلفون: | Leal É; Federal University of Pará, Belém, Brazil., Villanova FE; Federal University of Pará, Belém, Brazil., Lin W; Division of Swine Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of CAAS, Heilongjiang, PR China., Hu F; Division of Swine Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of CAAS, Heilongjiang, PR China., Liu Q; Division of Swine Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of CAAS, Heilongjiang, PR China., Liu Y; China Institute of Veterinary Drug Control, Beijing 100081, PR China., Cui S; Division of Swine Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of CAAS, Heilongjiang, PR China. |
| المصدر: | The Journal of general virology [J Gen Virol] 2012 Dec; Vol. 93 (Pt 12), pp. 2692-2704. Date of Electronic Publication: 2012 Sep 19. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Retracted Publication |
| اللغة: | English |
| بيانات الدورية: | Publisher: Microbiology Society Country of Publication: England NLM ID: 0077340 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1465-2099 (Electronic) Linking ISSN: 00221317 NLM ISO Abbreviation: J Gen Virol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : London : Microbiology Society Original Publication: London, Cambridge Univ. Press for the Society for General Microbiology. |
| مواضيع طبية MeSH: | Parvovirus, Porcine/*genetics, Animals ; Evolution, Molecular ; Genome, Viral ; Molecular Sequence Data ; Parvovirus, Porcine/classification ; Phylogeny ; Reassortant Viruses/classification ; Reassortant Viruses/genetics ; Recombination, Genetic ; Sus scrofa ; Viral Nonstructural Proteins/genetics ; Viral Structural Proteins/genetics |
| مستخلص: | A detailed analysis of the Ns1/Vp1Vp2 genome region of the porcine parvovirus (PPV) strains isolated from vaccinated animals was performed. We found many inconsistencies in the phylogenetic trees of these viral isolates, such as low statistical support and strains with long branches in the phylogenetic trees. Thus, we used distance-based and phylogenetic methods to distinguish de facto recombinants from spurious recombination signals. We found a mosaic virus in which the Ns1 gene was acquired from one PPV clade and the Vp1Vp2 gene was acquired from a distinct phylogenetic clade. We also described the interclade mosaic structure of the Vp1Vp2 gene of a reference strain. If recombination is an adaptive mechanism over the course of PPV evolution, we would likely observe increasing numbers of chimeric strains over time. However, when the PPV sequences isolated from 1964 to 2011 were analysed, only two chimeric strains were detected. Thus, PPV recombination is an independent event, resulting from close contact between animals housed in high-density conditions. |
| التعليقات: | Retraction in: J Gen Virol. 2013 Feb;94(Pt 2):464. (PMID: 23329682) |
| سلسلة جزيئية: | GENBANK JX568153; JX568154; JX568155; JX568156; JX568157; JX568158 |
| المشرفين على المادة: | 0 (NS1 protein, parvovirus) 0 (Viral Nonstructural Proteins) 0 (Viral Structural Proteins) |
| تواريخ الأحداث: | Date Created: 20120921 Date Completed: 20130125 Latest Revision: 20200226 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1099/vir.0.045765-0 |
| PMID: | 22993191 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1465-2099 |
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| DOI: | 10.1099/vir.0.045765-0 |