دورية أكاديمية
[Correction of early cognitive disorders in school-age children operated under total intravenous anaesthesia].
| العنوان: | [Correction of early cognitive disorders in school-age children operated under total intravenous anaesthesia]. |
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| المؤلفون: | Ovezov AM, Lobov MA, Panteleeva MV, Lugovoĭ AV, Miatchin PS, Gus'kov IE |
| المصدر: | Anesteziologiia i reanimatologiia [Anesteziol Reanimatol] 2012 May-Jun (3), pp. 25-9. |
| نوع المنشور: | English Abstract; Journal Article; Randomized Controlled Trial |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Meditsina Country of Publication: Russia (Federation) NLM ID: 7705399 Publication Model: Print Cited Medium: Print ISSN: 0201-7563 (Print) Linking ISSN: 02017563 NLM ISO Abbreviation: Anesteziol Reanimatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Moskva : Meditsina Original Publication: Moskva, Meditsina. |
| مواضيع طبية MeSH: | Anesthesia, Intravenous/*adverse effects , Anesthetics, Combined/*adverse effects , Anesthetics, Intravenous/*adverse effects , Cognition Disorders/*prevention & control , Nootropic Agents/*therapeutic use , Pantothenic Acid/*analogs & derivatives , gamma-Aminobutyric Acid/*analogs & derivatives, Adolescent ; Anesthesia, Intravenous/methods ; Child ; Cognition Disorders/etiology ; Cognition Disorders/psychology ; Female ; Fentanyl/adverse effects ; Humans ; Male ; Memory, Long-Term/drug effects ; Memory, Short-Term/drug effects ; Neuropsychological Tests ; Nootropic Agents/administration & dosage ; Pantothenic Acid/administration & dosage ; Pantothenic Acid/therapeutic use ; Perioperative Period ; Propofol/adverse effects ; Treatment Outcome ; gamma-Aminobutyric Acid/administration & dosage ; gamma-Aminobutyric Acid/therapeutic use |
| مستخلص: | Unlabelled: The aim of the study was to assess the possibility and effectiveness of hopaten acid use for early postoperative cognitive dysfunction correction in children of school age. Materials and Methods: In compliance with inclusion and exclusion criteria, totally 40 children of school age (7-16 years old, ASA status I-II) with surgical pathology: (varicocele, cryptorchidism, inguinal hernia) were included A comperative assessment of neuropsychic status during pre - and postoperative are period in children, operated under propofol-fentanyl total intravenous anesthesia (TIVA) was conducted All patients were randomized to the control (without cepebroprotection 1st group, 20 children) and experimental (using cepebroprotection with hopaten acid within 1 month after the operation, 2nd group, 20 children) groups. Dimension of the study: Harvard standard monitoring, respiratory gas composition, neuropsychic tests (Bourdon test, "10 words test", etc.). Results: For full compatibility groups (age, ASA status and anthropometric data, equal operation duration and the equipotential drug dosage adjustment is revealed, that in group of propofol-fentanyl TIVA in the early postoperative period in school age children postoperative cognitive dysfunction (POCD) is developing, which in case of absence of the corresponding correction is maintained after 1 month after operation (at least) in 80% of cases. In the application of hopaten acid cerebroprotection (40 mg/kg per day) severity of POCD reliably is reduced or compensated by the time of discharge from the hospital (3-7-th day when non-traumatic interventions), and 1 month after the operation in 30% of patients experienced improvement of cognitive functions, which proves the effectiveness of hopaten acid for POCD treatment. Conclusion: In case of propofol-fentanyl TIVA anesthesia in children of school age is indicated preventive prescription of multimodal cerebroprotectors without age limitations (for example hopaten acid (40 mg/kg per day) for POCD treatment. |
| المشرفين على المادة: | 0 (Anesthetics, Combined) 0 (Anesthetics, Intravenous) 0 (Nootropic Agents) 1977-33-9 (pantogab) 19F5HK2737 (Pantothenic Acid) 56-12-2 (gamma-Aminobutyric Acid) UF599785JZ (Fentanyl) YI7VU623SF (Propofol) |
| تواريخ الأحداث: | Date Created: 20120922 Date Completed: 20121127 Latest Revision: 20131121 |
| رمز التحديث: | 20240628 |
| PMID: | 22993919 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0201-7563 |
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