دورية أكاديمية
Lifestyle factors increasing adiponectin synthesis and secretion.
| العنوان: | Lifestyle factors increasing adiponectin synthesis and secretion. |
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| المؤلفون: | Tishinsky JM; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada., Dyck DJ, Robinson LE |
| المصدر: | Vitamins and hormones [Vitam Horm] 2012; Vol. 90, pp. 1-30. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 0413601 Publication Model: Print Cited Medium: Internet ISSN: 0083-6729 (Print) Linking ISSN: 00836729 NLM ISO Abbreviation: Vitam Horm Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, Academic Press. |
| مواضيع طبية MeSH: | Life Style*, Adiponectin/*biosynthesis , Adiponectin/*metabolism, AMP-Activated Protein Kinases ; Adipocytes ; Adipose Tissue ; Diet ; Exercise ; Fatty Acids ; Fatty Acids, Omega-3 ; Humans ; Inflammation ; Macrophages ; PPAR gamma ; Protein Processing, Post-Translational ; Thiazolidinediones ; Weight Loss |
| مستخلص: | Adiponectin is an anti-inflammatory adipokine released from adipose tissue that is known to exert insulin-sensitizing effects in skeletal muscle and liver. Given that the secretion of adiponectin is impaired in obesity and related pathologies, strategies to enhance its synthesis and secretion are of interest. There is evidence that several lifestyle factors, including consumption of dietary long-chain n-3 PUFA, TZD administration, and weight loss can increase adiponectin synthesis and secretion. The effect of chronic exercise, independent of weight loss, is variable and less convincing. Potential mechanisms by which such lifestyle factors exert their favorable effects on adiponectin include activation of PPARγ and AMPK, regulation of posttranslational modifications, and changes in adipose tissue morphology and macrophage infiltration. As a clear role for adiponectin in mitigating obesity-related impairments in lipid metabolism and insulin sensitivity is evident, further research investigating factors that enhance adiponectin synthesis and secretion is distinctly warranted. (Copyright © 2012 Elsevier Inc. All rights reserved.) |
| المشرفين على المادة: | 0 (Adiponectin) 0 (Fatty Acids) 0 (Fatty Acids, Omega-3) 0 (PPAR gamma) 0 (Thiazolidinediones) EC 2.7.11.31 (AMP-Activated Protein Kinases) |
| تواريخ الأحداث: | Date Created: 20120929 Date Completed: 20130219 Latest Revision: 20181202 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/B978-0-12-398313-8.00001-4 |
| PMID: | 23017710 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0083-6729 |
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| DOI: | 10.1016/B978-0-12-398313-8.00001-4 |