دورية أكاديمية
Derivatives of the cationic plant alkaloids berberine and palmatine amplify protonophorous activity of fatty acids in model membranes and mitochondria.
| العنوان: | Derivatives of the cationic plant alkaloids berberine and palmatine amplify protonophorous activity of fatty acids in model membranes and mitochondria. |
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| المؤلفون: | Pustovidko AV; Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology, Vorobyevy Gory 1, 119991 Moscow, Russia., Rokitskaya TI, Severina II, Simonyan RA, Trendeleva TA, Lyamzaev KG, Antonenko YN, Rogov AG, Zvyagilskaya RA, Skulachev VP, Chernyak BV |
| المصدر: | Mitochondrion [Mitochondrion] 2013 Sep; Vol. 13 (5), pp. 520-5. Date of Electronic Publication: 2012 Sep 29. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100968751 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8278 (Electronic) Linking ISSN: 15677249 NLM ISO Abbreviation: Mitochondrion Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier Science, c2001- |
| مواضيع طبية MeSH: | Berberine/*metabolism , Berberine Alkaloids/*metabolism , Fatty Acids/*metabolism , Membranes/*metabolism , Mitochondria/*metabolism, Alkaloids/metabolism ; Cations/metabolism ; Hydrogen/metabolism ; Membranes/drug effects ; Mitochondria/drug effects ; Plastoquinone/metabolism |
| مستخلص: | Previously it has been shown by our group that berberine and palmatine, penetrating cations of plant origin, when conjugated with plastoquinone (SkQBerb and SkQPalm), can accumulate in isolated mitochondria or in mitochondria of living cells and effectively protect them from oxidative damage. In the present work, we demonstrate that SkQBerb, SkQPalm, and their analogs lacking the plastoquinone moiety (C10Berb and C10Palm) operate as mitochondria-targeted compounds facilitating protonophorous effect of free fatty acids. These compounds induce proton transport mediated by small concentrations of added fatty acids both in planar and liposomal model lipid membranes. In mitochondria, such an effect can be carried out by endogenous fatty acids and the adenine nucleotide translocase. (Copyright © 2012 Elsevier B.V. and Mitochondria Research Society. All rights reserved. All rights reserved.) |
| فهرسة مساهمة: | Keywords: 10-(6-plastoquinonyl)decylrhodamine-19; 10-(6-plastoquinonyl)decyltriphenylphosphonium; 13-(decyloxycarbonylmethyl) palmatine; 13-(decyloxycarbonylmethyl)berberine; 13-[9-(6-plastoquinonyl) nonyloxycarbonylmethyl] palmatine; 13-[9-(6-plastoquinonyl)nonyloxycarbonylmethyl]berberine; 2,4-dinitrophenol; 3,3′-dipropylthiadicarbocyanine iodide; ANT; BLM; BSA; Berberine; C(10)Berb; C(10)Palm; C(12)TPP; CATR; CCCP; DNP; DPhPC; DiS-C3-(5); FCCP; FFA; Mitochondria; Natural penetrating cations; Palmatine; ROS; SkQ1; SkQBerb; SkQPalm; SkQR1; Uncouplers; adenine nucleotide translocase; bilayer planar phospholipid membrane; bovine serum albumin; carbonyl cyanide p-(trifluromethoxy)phenylhydrazone; carbonylcyanide m-chlorophenylhydrazone; carboxyatractyloside; diphytanoyl phosphatidylcholine; dodecyltriphenylphosphonium; free fatty acid; reactive oxygen species; transmembrane electric potential difference; ΔΨ |
| المشرفين على المادة: | 0 (Alkaloids) 0 (Berberine Alkaloids) 0 (Cations) 0 (Fatty Acids) 0I8Y3P32UF (Berberine) 7YNJ3PO35Z (Hydrogen) G50C034217 (palmatine) OAC30J69CN (Plastoquinone) |
| تواريخ الأحداث: | Date Created: 20121003 Date Completed: 20140310 Latest Revision: 20130826 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.mito.2012.09.006 |
| PMID: | 23026390 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-8278 |
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| DOI: | 10.1016/j.mito.2012.09.006 |