دورية أكاديمية
Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates.
| العنوان: | Solid-state characterization and dissolution properties of Fluvastatin sodium salt hydrates. |
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| المؤلفون: | Borgmann SH; Federal University of Santa Catarina, Florianópolis, Brazil., Bernardi LS, Rauber GS, Oliveira PR, Campos CE, Monti G, Cuffini SL, Cardoso SG |
| المصدر: | Pharmaceutical development and technology [Pharm Dev Technol] 2013 Mar-Apr; Vol. 18 (2), pp. 525-34. Date of Electronic Publication: 2012 Oct 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 9610932 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-9867 (Electronic) Linking ISSN: 10837450 NLM ISO Abbreviation: Pharm Dev Technol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Monticello, NY : Marcel Dekker, c1996- |
| مواضيع طبية MeSH: | Fatty Acids, Monounsaturated/*chemistry , Indoles/*chemistry, Calorimetry, Differential Scanning/methods ; Crystallization/methods ; Fluvastatin ; Magnetic Resonance Spectroscopy/methods ; Microscopy, Electron, Scanning/methods ; Solubility ; Solvents/chemistry ; Spectroscopy, Fourier Transform Infrared/methods ; Thermogravimetry/methods ; X-Ray Diffraction/methods |
| مستخلص: | The present study reports the solid-state properties of Fluvastatin sodium salt crystallized from different solvents for comparison with crystalline forms of the commercially available raw material and United States Pharmacopeia (USP) reference standard. Fluvastatin (FLV) samples were characterized by several techniques; such as X-ray powder diffractometry, differential scanning calorimetry, thermogravimetry, liquid and solid-state nuclear magnetic resonance spectroscopy, diffuse reflectance infrared Fourier transform spectroscopy, and scanning electron microscopy. In addition, intrinsic dissolution rate (IDR) of samples was performed in order to study the influence of crystalline form and other factors on rate and extent of dissolution. Three different forms were found. The commercial raw material and Fluvastatin-Acetonitrile (ACN) were identified as "form I" hydrate, the USP reference standard as "form II" hydrate and an ethanol solvate which presented a mixture of phases. Form I, with water content of 4%, was identified as monohydrate. |
| المشرفين على المادة: | 0 (Fatty Acids, Monounsaturated) 0 (Indoles) 0 (Solvents) 4L066368AS (Fluvastatin) |
| تواريخ الأحداث: | Date Created: 20121005 Date Completed: 20130708 Latest Revision: 20181202 |
| رمز التحديث: | 20240628 |
| DOI: | 10.3109/10837450.2012.727000 |
| PMID: | 23033850 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1097-9867 |
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| DOI: | 10.3109/10837450.2012.727000 |