دورية أكاديمية
The impact of age on outcome of embryonal and alveolar rhabdomyosarcoma patients. A multicenter study.
| العنوان: | The impact of age on outcome of embryonal and alveolar rhabdomyosarcoma patients. A multicenter study. |
|---|---|
| المؤلفون: | Van Gaal JC; Department of Medical Oncology, Division of Pediatric Oncology/Hematology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Van Der Graaf WT, Rikhof B, Van Hoesel QG, Teerenstra S, Suurmeijer AJ, Flucke UE, Loeffen JL, Sleijfer S, De Bont ES |
| المصدر: | Anticancer research [Anticancer Res] 2012 Oct; Vol. 32 (10), pp. 4485-97. |
| نوع المنشور: | Journal Article; Multicenter Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8102988 Publication Model: Print Cited Medium: Internet ISSN: 1791-7530 (Electronic) Linking ISSN: 02507005 NLM ISO Abbreviation: Anticancer Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Attiki, Greece : International Institute of Anticancer Research Original Publication: Athens, Greece : Potamitis Press |
| مواضيع طبية MeSH: | Rhabdomyosarcoma, Alveolar/*mortality , Rhabdomyosarcoma, Embryonal/*mortality, Adolescent ; Adult ; Age Factors ; Aged ; Child ; Child, Preschool ; Disease-Free Survival ; Female ; Humans ; Infant ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Rhabdomyosarcoma, Alveolar/secondary ; Rhabdomyosarcoma, Embryonal/secondary ; Treatment Outcome ; Young Adult |
| مستخلص: | Background: The prognosis of rhabdomyosarcoma (RMS) in children and adolescents has improved since the introduction of multi-agent chemotherapy. However, outcome data of adults with RMS are scarce. This multicenter retrospective study investigated the effect of age on outcome of RMS. Patients and Methods: Data were collected from three Dutch University Medical Centers between 1977-2009. The effect of age and clinical prognostic factors on relapse-free and disease-specific survival (DSS) were analyzed. Results: Age as a continuous variable predicted poor survival in multivariate analysis. Five-year DSS was highest for non-metastatic embryonal RMS, followed by non-metastatic alveolar RMS and was poor in metastatic disease. Higher age correlated with unfavorable histological subtype (alveolar RMS) and with metastatic disease at presentation in embryonal RMS. In non-metastatic embryonal RMS and in all alveolar RMS, higher age was an adverse prognostic factor of outcome. Conclusion: This study indicates that age is a negative predictor of survival in patients with embryonal and alveolar RMS. |
| تواريخ الأحداث: | Date Created: 20121013 Date Completed: 20130114 Latest Revision: 20121012 |
| رمز التحديث: | 20221213 |
| PMID: | 23060577 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1791-7530 |
|---|