دورية أكاديمية
أعرض في EDS

Diversion of phagosome trafficking by pathogenic Rhodococcus equi depends on mycolic acid chain length.

التفاصيل البيبلوغرافية
العنوان: Diversion of phagosome trafficking by pathogenic Rhodococcus equi depends on mycolic acid chain length.
المؤلفون: Sydor T; Institute for Cell Biology, University of Bonn, Bonn, Germany., von Bargen K, Hsu FF, Huth G, Holst O, Wohlmann J, Becken U, Dykstra T, Söhl K, Lindner B, Prescott JF, Schaible UE, Utermöhlen O, Haas A
المصدر: Cellular microbiology [Cell Microbiol] 2013 Mar; Vol. 15 (3), pp. 458-73. Date of Electronic Publication: 2012 Nov 13.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Hindawi Country of Publication: India NLM ID: 100883691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1462-5822 (Electronic) Linking ISSN: 14625814 NLM ISO Abbreviation: Cell Microbiol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2022- : Mumbai : Hindawi
Original Publication: Oxford : Wiley-Blackwell, c1999-
مواضيع طبية MeSH: Host-Pathogen Interactions*, Macrophages/*microbiology , Mycolic Acids/*metabolism , Phagosomes/*microbiology , Rhodococcus equi/*pathogenicity, 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase/genetics ; Actinomycetales Infections/immunology ; Actinomycetales Infections/microbiology ; Animals ; Cell Line ; DNA Transposable Elements ; DNA, Bacterial/chemistry ; DNA, Bacterial/genetics ; Disease Models, Animal ; Gene Knockout Techniques ; Mice ; Molecular Sequence Data ; Mutagenesis, Insertional ; Rhodococcus equi/genetics ; Rhodococcus equi/immunology ; Sequence Analysis, DNA ; Virulence
مستخلص: Rhodococcus equi is a close relative of Mycobacterium spp. and a facultative intracellular pathogen which arrests phagosome maturation in macrophages before the late endocytic stage. We have screened a transposon mutant library of R. equi for mutants with decreased capability to prevent phagolysosome formation. This screen yielded a mutant in the gene for β-ketoacyl-(acyl carrier protein)-synthase A (KasA), a key enzyme of the long-chain mycolic acid synthesizing FAS-II system. The longest kasA mutant mycolic acid chains were 10 carbon units shorter than those of wild-type bacteria. Coating of non-pathogenic E. coli with purified wild-type trehalose dimycolate reduced phagolysosome formation substantially which was not the case with shorter kasA mutant-derived trehalose dimycolate. The mutant was moderately attenuated in macrophages and in a mouse infection model, but was fully cytotoxic.Whereas loss of KasA is lethal in mycobacteria, R. equi kasA mutant multiplication in broth was normal proving that long-chain mycolic acid compounds are not necessarily required for cellular integrity and viability of the bacteria that typically produce them. This study demonstrates a central role of mycolic acid chain length in diversion of trafficking by R. equi.
(© 2012 Blackwell Publishing Ltd.)
References: Langmuir. 2009 May 5;25(9):5193-8. (PMID: 19323499)
Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14925-30. (PMID: 15466710)
Mol Microbiol. 2007 Jun;64(6):1442-54. (PMID: 17555433)
Microbiology (Reading). 2003 Aug;149(Pt 8):2049-2059. (PMID: 12904545)
J Clin Microbiol. 1991 Mar;29(3):439-43. (PMID: 2037660)
Cell Microbiol. 2008 Sep;10(9):1839-53. (PMID: 18485117)
Mol Biol Cell. 2004 Feb;15(2):751-60. (PMID: 14617817)
Cell. 2005 Dec 2;123(5):861-73. (PMID: 16325580)
Vet Microbiol. 2008 Apr 30;128(3-4):327-41. (PMID: 18063488)
Chem Biol. 2009 May 29;16(5):499-509. (PMID: 19477414)
J Bacteriol. 2005 Nov;187(22):7596-606. (PMID: 16267284)
Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5157-62. (PMID: 17360388)
Infect Immun. 1994 Oct;62(10):4167-75. (PMID: 7927672)
J Clin Microbiol. 1993 Oct;31(10):2780-2. (PMID: 8253982)
Traffic. 2007 Apr;8(4):311-30. (PMID: 17274798)
Cell Microbiol. 2008 Jul;10(7):1530-45. (PMID: 18363878)
Annu Rev Biochem. 1995;64:29-63. (PMID: 7574484)
J Biol Chem. 2000 Jun 2;275(22):16857-64. (PMID: 10747933)
Infect Immun. 2004 Feb;72(2):853-62. (PMID: 14742529)
Cell Microbiol. 2005 Sep;7(9):1263-70. (PMID: 16098214)
Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13642-7. (PMID: 15340136)
Infect Immun. 2011 May;79(5):2098-111. (PMID: 21383050)
PLoS Genet. 2010 Sep 30;6(9):e1001145. (PMID: 20941392)
J Biol Chem. 2002 Aug 30;277(35):31722-33. (PMID: 12072437)
PLoS Pathog. 2009 Feb;5(2):e1000289. (PMID: 19197369)
Infect Immun. 2000 Dec;68(12):6840-7. (PMID: 11083803)
Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):737-40. (PMID: 1992465)
Antonie Van Leeuwenhoek. 1998 Jul-Oct;74(1-3):49-58. (PMID: 10068788)
Antimicrob Agents Chemother. 1996 Dec;40(12):2813-9. (PMID: 9124847)
J Biotechnol. 2006 May 29;123(3):259-72. (PMID: 16360900)
Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5437-42. (PMID: 12702770)
Microbiology (Reading). 2010 Jun;156(Pt 6):1836-1847. (PMID: 20299405)
J Immunol. 2010 Mar 15;184(6):2756-60. (PMID: 20164423)
J Immunol. 2005 Apr 15;174(8):5007-15. (PMID: 15814731)
Microbiol Immunol. 1991;35(3):175-85. (PMID: 1870435)
Anal Biochem. 2011 Feb 1;409(1):112-22. (PMID: 20946862)
Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):4011-6. (PMID: 10097154)
Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15582-7. (PMID: 17030794)
Biochim Biophys Acta. 1994 Aug 24;1194(1):53-60. (PMID: 8075141)
Traffic. 2005 Aug;6(8):635-53. (PMID: 15998320)
Vet Microbiol. 1987 Aug;14(3):295-305. (PMID: 3672872)
J Vet Med Sci. 1998 Feb;60(2):277-9. (PMID: 9524960)
Proc Natl Acad Sci U S A. 2010 Nov 30;107(48):20726-31. (PMID: 21071675)
J Exp Med. 2009 Dec 21;206(13):2865-8. (PMID: 20008525)
Clin Microbiol Rev. 2005 Jan;18(1):81-101. (PMID: 15653820)
Biophys J. 2007 Dec 1;93(11):4018-30. (PMID: 17704144)
EMBO J. 1996 Jul 15;15(14):3547-54. (PMID: 8670858)
Tuberculosis (Edinb). 2011 May;91(3):187-95. (PMID: 21330212)
Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11254-8. (PMID: 7479975)
Immunol Cell Biol. 2000 Aug;78(4):301-10. (PMID: 10947853)
Ann Clin Lab Sci. 2006 Autumn;36(4):371-86. (PMID: 17127724)
Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3963-7. (PMID: 18316738)
J Am Soc Mass Spectrom. 2011 Dec;22(12):2160-70. (PMID: 21972013)
Mol Microbiol. 2003 May;48(4):875-88. (PMID: 12753183)
Innate Immun. 2011 Aug;17(4):388-402. (PMID: 20682584)
Infect Immun. 2009 Dec;77(12):5676-81. (PMID: 19797071)
Appl Microbiol Biotechnol. 2006 May;70(5):605-11. (PMID: 16133336)
Tuberculosis (Edinb). 2002;82(4-5):149-60. (PMID: 12464486)
Cancer Chemother Pharmacol. 2002 Mar;49(3):187-93. (PMID: 11935210)
J Exp Med. 2009 Dec 21;206(13):2879-88. (PMID: 20008526)
J Bacteriol. 2003 Apr;185(8):2644-52. (PMID: 12670990)
Prog Lipid Res. 1998 Jul-Aug;37(2-3):143-79. (PMID: 9829124)
Biophys J. 2011 Jan 5;100(1):90-7. (PMID: 21190660)
Vet Microbiol. 2006 Dec 20;118(3-4):240-6. (PMID: 16979852)
FEMS Microbiol Rev. 2009 Sep;33(5):870-91. (PMID: 19453748)
Biophys J. 1996 Dec;71(6):3311-9. (PMID: 8968600)
J Biol Chem. 2005 Sep 16;280(37):32539-47. (PMID: 16040614)
Mol Microbiol. 2003 Oct;50(1):115-28. (PMID: 14507368)
Vet Microbiol. 1987 Aug;14(3):307-20. (PMID: 3672873)
PLoS Pathog. 2010 Sep 09;6(9):e1001100. (PMID: 20844580)
Mol Microbiol. 2003 Sep;49(6):1547-63. (PMID: 12950920)
Bacteriol Rev. 1957 Sep;21(3):195-213. (PMID: 13471458)
Infect Immun. 2007 Feb;75(2):581-91. (PMID: 17088345)
Biochem Biophys Res Commun. 1983 Sep 30;115(3):1108-13. (PMID: 6354189)
Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):314-9. (PMID: 14695899)
Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14628-33. (PMID: 17804795)
معلومات مُعتمدة: DK056341 United States DK NIDDK NIH HHS; RE000954 United States PHS HHS; P30 DK056341 United States DK NIDDK NIH HHS; P41 GM103422 United States GM NIGMS NIH HHS; P60 DK020579 United States DK NIDDK NIH HHS; P30 DK020579 United States DK NIDDK NIH HHS; P41 RR000954 United States RR NCRR NIH HHS; DK020579 United States DK NIDDK NIH HHS; WT082825 United Kingdom WT_ Wellcome Trust; United Kingdom Wellcome Trust
سلسلة جزيئية: GENBANK JN030359
المشرفين على المادة: 0 (DNA Transposable Elements)
0 (DNA, Bacterial)
0 (Mycolic Acids)
EC 2.3.1.41 (3-Oxoacyl-(Acyl-Carrier-Protein) Synthase)
تواريخ الأحداث: Date Created: 20121020 Date Completed: 20130729 Latest Revision: 20211021
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC3864644
DOI: 10.1111/cmi.12050
PMID: 23078612
قاعدة البيانات: MEDLINE
الوصف
تدمد:1462-5822
DOI:10.1111/cmi.12050