دورية أكاديمية
Frequent intratype neutralization by plasma immunoglobulin a identified in HIV type 2 infection.
| العنوان: | Frequent intratype neutralization by plasma immunoglobulin a identified in HIV type 2 infection. |
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| المؤلفون: | Özkaya Şahin G; Department of Laboratory Medicine Lund, Lund University, Lund, Sweden. gulsen.ozkaya_sahin@med.lu.se, Månsson F, Palm AA, Vincic E, da Silva Z, Medstrand P, Norrgren H, Fenyö EM, Jansson M |
| المصدر: | AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2013 Mar; Vol. 29 (3), pp. 470-8. Date of Electronic Publication: 2012 Nov 21. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 8709376 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1931-8405 (Electronic) Linking ISSN: 08892229 NLM ISO Abbreviation: AIDS Res Hum Retroviruses Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Larchmont, NY : Mary Ann Liebert Original Publication: [New York] : Mary Ann Liebert, [c1987- |
| مواضيع طبية MeSH: | Antibodies, Neutralizing/*immunology , HIV Antibodies/*immunology , HIV Infections/*immunology , HIV Infections/*virology , HIV-2/*immunology , Immunoglobulin A/*immunology , Plasma/*immunology, Adult ; Antibodies, Neutralizing/isolation & purification ; Female ; HIV Antibodies/isolation & purification ; HIV-1/immunology ; Humans ; Immunoglobulin A/isolation & purification ; Neutralization Tests ; Viral Plaque Assay ; Young Adult |
| مستخلص: | Human immunodeficiency virus type 2 (HIV-2) is less transmissible and less pathogenic compared to HIV-1 and, when matched for CD4(+) T cell count, the plasma viral load in HIV-2-infected individuals is approximately one log lower than in HIV-1-infected individuals. The explanation for these observations is elusive, but differences in virus controlling immunity generated in the two infections may be contributing factors. In the present study, we investigated neutralization by immunoglobulin A (IgA), in parallel with IgG, purified from plasma of HIV-1, HIV-2, and HIV-1/HIV-2 dually (HIV-D) infected individuals. Neutralization was analyzed against HIV-1 and HIV-2 isolates using a plaque reduction assay. In HIV-2 infection, intratype-specific neutralization by IgA was frequently detected, although at a lesser magnitude then the corresponding IgG neutralizing titers. In contrast, neutralization by IgA could rarely be demonstrated in HIV-1 infection despite similar plasma IgA levels in both infections. In addition, IgA and IgG of HIV-D plasma neutralized the HIV-2 isolate more potently than the HIV-1 isolate, suggesting that the difference between neutralizing activity of plasma IgA and IgG depends on the virus itself. Taken together, these findings suggest that both IgA and IgG add to the potent intratype neutralizing activity detected in HIV-2 plasma, which may contribute to virus control in HIV-2 infection. |
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| المشرفين على المادة: | 0 (Antibodies, Neutralizing) 0 (HIV Antibodies) 0 (Immunoglobulin A) |
| تواريخ الأحداث: | Date Created: 20121024 Date Completed: 20130802 Latest Revision: 20211021 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC3581020 |
| DOI: | 10.1089/AID.2012.0219 |
| PMID: | 23088167 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1931-8405 |
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| DOI: | 10.1089/AID.2012.0219 |