دورية أكاديمية
أعرض في EDS

Mouse sperm membrane potential hyperpolarization is necessary and sufficient to prepare sperm for the acrosome reaction.

التفاصيل البيبلوغرافية
العنوان: Mouse sperm membrane potential hyperpolarization is necessary and sufficient to prepare sperm for the acrosome reaction.
المؤلفون: De La Vega-Beltran JL; Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos 62210, México., Sánchez-Cárdenas C, Krapf D, Hernandez-González EO, Wertheimer E, Treviño CL, Visconti PE, Darszon A
المصدر: The Journal of biological chemistry [J Biol Chem] 2012 Dec 28; Vol. 287 (53), pp. 44384-93. Date of Electronic Publication: 2012 Oct 24.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
أسماء مطبوعة: Publication: 2021- : [New York, NY] : Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology
Original Publication: Baltimore, MD : American Society for Biochemistry and Molecular Biology
مواضيع طبية MeSH: Acrosome Reaction*, Spermatozoa/*physiology, Animals ; Cell Membrane/metabolism ; Cell Polarity ; Female ; Male ; Membrane Potentials ; Mice ; Phosphorylation
مستخلص: Mammalian sperm are unable to fertilize the egg immediately after ejaculation; they acquire this capacity during migration in the female reproductive tract. This maturational process is called capacitation and in mouse sperm it involves a plasma membrane reorganization, extensive changes in the state of protein phosphorylation, increases in intracellular pH (pH(i)) and Ca(2+) ([Ca(2+)](i)), and the appearance of hyperactivated motility. In addition, mouse sperm capacitation is associated with the hyperpolarization of the cell membrane potential. However, the functional role of this process is not known. In this work, to dissect the role of this membrane potential change, hyperpolarization was induced in noncapacitated sperm using either the ENaC inhibitor amiloride, the CFTR agonist genistein or the K(+) ionophore valinomycin. In this experimental setting, other capacitation-associated processes such as activation of a cAMP-dependent pathway and the consequent increase in protein tyrosine phosphorylation were not observed. However, hyperpolarization was sufficient to prepare sperm for the acrosome reaction induced either by depolarization with high K(+) or by addition of solubilized zona pellucida (sZP). Moreover, K(+) and sZP were also able to increase [Ca(2+)](i) in non-capacitated sperm treated with these hyperpolarizing agents but not in untreated cells. On the other hand, in conditions that support capacitation-associated processes blocking hyperpolarization by adding valinomycin and increasing K(+) concentrations inhibited the agonist-induced acrosome reaction as well as the increase in [Ca(2+)](i). Altogether, these results suggest that sperm hyperpolarization by itself is key to enabling mice sperm to undergo the acrosome reaction.
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معلومات مُعتمدة: R01 HD038082 United States HD NICHD NIH HHS; R01 HD044044 United States HD NICHD NIH HHS; HD038082 United States HD NICHD NIH HHS; R01 HD44044 United States HD NICHD NIH HHS
تواريخ الأحداث: Date Created: 20121026 Date Completed: 20130325 Latest Revision: 20211021
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3531752
DOI: 10.1074/jbc.M112.393488
PMID: 23095755
قاعدة البيانات: MEDLINE
الوصف
تدمد:1083-351X
DOI:10.1074/jbc.M112.393488