دورية أكاديمية
Synbiotic therapy decreases microbial translocation and inflammation and improves immunological status in HIV-infected patients: a double-blind randomized controlled pilot trial.
العنوان: | Synbiotic therapy decreases microbial translocation and inflammation and improves immunological status in HIV-infected patients: a double-blind randomized controlled pilot trial. |
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المؤلفون: | González-Hernández LA; HIV Unit Hospital Civil de Guadalajara Fray Antonio Alcalde, University of Guadalajara, Calle Hospital 278, Colonia Alcalde Barranquitas, Guadalajara, Jalisco, 44280, Mexico., Jave-Suarez LF, Fafutis-Morris M, Montes-Salcedo KE, Valle-Gutierrez LG, Campos-Loza AE, Enciso-Gómez LF, Andrade-Villanueva JF |
المصدر: | Nutrition journal [Nutr J] 2012 Oct 29; Vol. 11, pp. 90. Date of Electronic Publication: 2012 Oct 29. |
نوع المنشور: | Comparative Study; Journal Article; Randomized Controlled Trial |
اللغة: | English |
بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101152213 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2891 (Electronic) Linking ISSN: 14752891 NLM ISO Abbreviation: Nutr J Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : BioMed Central, 2002- |
مواضيع طبية MeSH: | Bacterial Translocation* , Prebiotics*/adverse effects , Probiotics*/adverse effects , Probiotics*/isolation & purification, Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use , HIV Enteropathy/*diet therapy , Intestinal Mucosa/*microbiology, Adult ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Bifidobacterium/classification ; Bifidobacterium/growth & development ; Bifidobacterium/immunology ; Bifidobacterium/isolation & purification ; CD4 Lymphocyte Count ; Cytokines/blood ; Cytokines/metabolism ; DNA, Bacterial/blood ; Disease Progression ; Double-Blind Method ; Feces/microbiology ; Female ; HIV Enteropathy/immunology ; HIV Enteropathy/microbiology ; HIV Enteropathy/physiopathology ; Humans ; Intestinal Mucosa/immunology ; Intestinal Mucosa/physiopathology ; Lacticaseibacillus rhamnosus/classification ; Lacticaseibacillus rhamnosus/growth & development ; Lacticaseibacillus rhamnosus/immunology ; Lacticaseibacillus rhamnosus/isolation & purification ; Male ; Mexico ; Pilot Projects ; Quality of Life ; Young Adult |
مستخلص: | Background: HIV-infection results in damage and dysfunction of the gastrointestinal system. HIV enteropathy includes pronounced CD4+ T-cell loss, increased intestinal permeability, and microbial translocation that promotes systemic immune activation, which is implicated in disease progression. A synbiotic is the combination of probiotics and prebiotics that could improve gut barrier function. Our study goal was to determine whether the use of a synbiotic, probiotics or a prebiotic can recover immunological parameters in HIV-infected subjects through of a reduction of microbial translocation and pro-inflammatory cytokine production. Methods: A randomized, double-blind controlled study was performed; twenty Antiretroviral treatment-naïve HIV-infected subjects were subgrouped and assigned to receive a synbiotic, probiotics, a prebiotic, or a placebo throughout 16 weeks. Results: We had no reports of serious adverse-events. From baseline to week 16, the synbiotic group showed a reduction in bacterial DNA concentrations in plasma (p = 0.048). Moreover, the probiotic and synbiotic groups demonstrated a decrease in total bacterial load in feces (p = 0.05). The probiotic group exhibited a significant increment of beneficial bacteria load (such as Bifidobacterium; p = 0.05) and a decrease in harmful bacteria load (such as Clostridium; p = 0.063). In the synbiotic group, the CD4+ T-cells count increased (median: +102 cells/μL; p = 0.05) and the level of Interleukin 6 cytokine decreased significantly (p = 0.016). Conclusions: Our study showed a significant increase in CD4+ T lymphocyte levels in the synbiotic group, which could delay the initiation of antiretroviral therapy and decrease costs in countries with limited resources. |
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المشرفين على المادة: | 0 (Anti-Inflammatory Agents, Non-Steroidal) 0 (Cytokines) 0 (DNA, Bacterial) 0 (Prebiotics) |
تواريخ الأحداث: | Date Created: 20121030 Date Completed: 20130412 Latest Revision: 20221207 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC3494555 |
DOI: | 10.1186/1475-2891-11-90 |
PMID: | 23101545 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1475-2891 |
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DOI: | 10.1186/1475-2891-11-90 |