دورية أكاديمية
Are unreliable release mechanisms conserved from NMJ to CNS?
العنوان: | Are unreliable release mechanisms conserved from NMJ to CNS? |
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المؤلفون: | Tarr TB; Department of Neuroscience, Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA., Dittrich M, Meriney SD |
المصدر: | Trends in neurosciences [Trends Neurosci] 2013 Jan; Vol. 36 (1), pp. 14-22. Date of Electronic Publication: 2012 Oct 25. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Applied Science Publishing Country of Publication: England NLM ID: 7808616 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-108X (Electronic) Linking ISSN: 01662236 NLM ISO Abbreviation: Trends Neurosci Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Barking : Elsevier Applied Science Publishing Original Publication: Amsterdam, New York, Elsevier/North-Holland Biomedical Press. |
مواضيع طبية MeSH: | Central Nervous System/*physiology , Neuromuscular Junction/*physiology , Synapses/*physiology , Synaptic Transmission/*physiology, Animals ; Humans |
مستخلص: | The frog neuromuscular junction (NMJ) is a strong and reliable synapse because, during activation, sufficient neurotransmitter is released to trigger a postsynaptic action potential (AP). Recent evidence supports the hypothesis that this reliability emerges from the assembly of thousands of unreliable single vesicle release sites. The mechanisms that govern this unreliability include a paucity of voltage-gated calcium channels, a low probability of calcium channel opening during an AP, and the rare triggering of synaptic vesicle fusion even when a calcium channel does open and allows calcium flux. Here, we discuss the evidence that these unreliable single vesicle release sites may be the fundamental building blocks of many types of synapses in both the peripheral and central nervous system (PNS and CNS, respectively). (Copyright © 2012 Elsevier Ltd. All rights reserved.) |
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معلومات مُعتمدة: | P41 GM103712 United States GM NIGMS NIH HHS; P41 RR006009 United States RR NCRR NIH HHS; P41RR06009 United States RR NCRR NIH HHS |
تواريخ الأحداث: | Date Created: 20121030 Date Completed: 20130722 Latest Revision: 20211021 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC4076818 |
DOI: | 10.1016/j.tins.2012.09.009 |
PMID: | 23102681 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1878-108X |
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DOI: | 10.1016/j.tins.2012.09.009 |