دورية أكاديمية
Mycophenolate mofetil versus azathioprine as maintenance therapy for lupus nephritis: a meta-analysis.
| العنوان: | Mycophenolate mofetil versus azathioprine as maintenance therapy for lupus nephritis: a meta-analysis. |
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| المؤلفون: | Feng L; Renal Division, Department of Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning., Deng J, Huo DM, Wu QY, Liao YH |
| المصدر: | Nephrology (Carlton, Vic.) [Nephrology (Carlton)] 2013 Feb; Vol. 18 (2), pp. 104-10. |
| نوع المنشور: | Journal Article; Meta-Analysis; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Science Country of Publication: Australia NLM ID: 9615568 Publication Model: Print Cited Medium: Internet ISSN: 1440-1797 (Electronic) Linking ISSN: 13205358 NLM ISO Abbreviation: Nephrology (Carlton) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Carlton, Vic., Australia : Blackwell Science, |
| مواضيع طبية MeSH: | Azathioprine/*therapeutic use , Immunosuppressive Agents/*therapeutic use , Lupus Nephritis/*drug therapy , Mycophenolic Acid/*analogs & derivatives, Adolescent ; Adult ; Aged ; Azathioprine/adverse effects ; Child ; Disease Progression ; Female ; Humans ; Immunosuppressive Agents/adverse effects ; Lupus Nephritis/diagnosis ; Lupus Nephritis/mortality ; Male ; Middle Aged ; Mycophenolic Acid/adverse effects ; Mycophenolic Acid/therapeutic use ; Odds Ratio ; Randomized Controlled Trials as Topic ; Recurrence ; Time Factors ; Treatment Outcome ; Young Adult |
| مستخلص: | Aim: The options for long-term maintenance therapy in lupus nephritis (LN) remain controversial. This meta-analysis of randomized controlled trials (RCTs) assessed the prognosis and safety of mycophenolate mofetil (MMF) versus azathioprine (AZA) used as maintenance therapy for lupus nephritis. Methods: The data of Cochrane Library, PubMed, EMBASE were retrieved to search the studies about the RCT studies that compared MMF with AZA used as maintenance therapy for lupus nephritis. We extracted the data reflecting prognosis, which included mortality, end-stage renal failure (ESRF), renal relapse, doubling serum creatinine, and adverse effects, then further analyzed the combined results of data and calculated the relative risk (RR). Results: Four RCT studies including 328 patients were enrolled into our meta-analysis. There was no difference between the patients receiving either MMF or AZA for maintenance therapy in preventing relapse, progression to end-stage renal failure, death and doubling of serum creatinine. MMF is not superior to AZA in terms of the risks of infection and gastrointestinal upset, but fewer patients receiving MMF developed leukopenia (RR 0.12; 95% confidence interval (CI), 0.04-0.39; P = 0.0004) and amenorrhoea (RR 0.17; 95% CI, 0.04-0.72; P = 0.02) than those receiving AZA. Conclusion: The current limited evidence suggests that MMF offers similar prognosis as AZA for maintenance therapy, while MMF appears safer than AZA in the treatment of lupus nephritis. (© 2012 The Authors. Nephrology © 2012 Asian Pacific Society of Nephrology.) |
| المشرفين على المادة: | 0 (Immunosuppressive Agents) HU9DX48N0T (Mycophenolic Acid) MRK240IY2L (Azathioprine) |
| تواريخ الأحداث: | Date Created: 20121102 Date Completed: 20130702 Latest Revision: 20161125 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/nep.12006 |
| PMID: | 23113811 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1440-1797 |
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| DOI: | 10.1111/nep.12006 |