دورية أكاديمية
Effects of cilostazol in kidney and skeletal striated muscle of Wistar rats submitted to acute ischemia and reperfusion of hind limbs.
| العنوان: | Effects of cilostazol in kidney and skeletal striated muscle of Wistar rats submitted to acute ischemia and reperfusion of hind limbs. |
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| المؤلفون: | Moreira Neto AA; Department of Surgery, Vascular Surgery Division, UMC, Mogi das Cruzes, SP, Brazil. femareis@yahoo.com.br, Souza Júnior SS, Capelozzi VL, Parra-Cuentas ER, Schmidt Júnior AF, Francisco Neto A, Rodrigues OR |
| المصدر: | Acta cirurgica brasileira [Acta Cir Bras] 2012 Nov; Vol. 27 (11), pp. 783-8. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sociedade Brasileira Para O Desenvolvimento Da Pesquisa Em Cirurgia Curso De Pos-Graduacao Em Tecnica Operatoria E Cirurgia Experimental Escola Paulista De Medicina Country of Publication: Brazil NLM ID: 9103983 Publication Model: Print Cited Medium: Internet ISSN: 1678-2674 (Electronic) Linking ISSN: 01028650 NLM ISO Abbreviation: Acta Cir Bras Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Sao Paulo : Sociedade Brasileira Para O Desenvolvimento Da Pesquisa Em Cirurgia Curso De Pos-Graduacao Em Tecnica Operatoria E Cirurgia Experimental Escola Paulista De Medicina Original Publication: São Paulo : A Sociedade, |
| مواضيع طبية MeSH: | Hindlimb/*blood supply , Hindlimb/*drug effects , Ischemia/*drug therapy , Kidney/*drug effects , Muscle, Skeletal/*drug effects , Reperfusion Injury/*drug therapy , Tetrazoles/*pharmacology , Vasodilator Agents/*pharmacology, Animals ; Apoptosis/drug effects ; Caspase 3/analysis ; Cilostazol ; Disease Models, Animal ; In Situ Nick-End Labeling ; Kidney/blood supply ; Kidney/pathology ; Male ; Muscle, Skeletal/blood supply ; Random Allocation ; Rats ; Rats, Wistar ; Reperfusion Injury/prevention & control ; Reproducibility of Results ; Tetrazoles/therapeutic use ; Time Factors ; Treatment Outcome ; Vasodilator Agents/therapeutic use |
| مستخلص: | Purpose: To investigate the effect of cilostazol, in kidney and skeletal muscle of rats submitted to acute ischemia and reperfusion. Methods: Fourty three animals were randomized and divided into two groups. Group I received a solution of cilostazol (10 mg/Kg) and group II received saline solution 0.9% (SS) by orogastric tube after ligature of the abdominal aorta. After four hours of ischemia the animals were divided into four subgroups: group IA (Cilostazol): two hours of reperfusion. Group IIA (SS): two hours of reperfusion. Group IB (Cilostazol): six hours of reperfusion. Group IIB (SS) six hours of reperfusion. After reperfusion, a left nephrectomy was performed and removal of the muscles of the hind limb. The histological parameters were studied. In kidney cylinders of myoglobin, vacuolar degeneration and acute tubular necrosis. In muscle interstitial edema, inflammatory infiltrate, hypereosinophilia fiber, cariopicnose and necrosis. Apoptosis was assessed by immunohistochemistry for cleaved caspase-3 and TUNEL. Results: There was no statistically significant difference between groups. Conclusion: Cilostazol had no protective effect on the kidney and the skeletal striated muscle in rats submitted to acute ischemia and reperfusion in this model. |
| المشرفين على المادة: | 0 (Tetrazoles) 0 (Vasodilator Agents) EC 3.4.22.- (Caspase 3) N7Z035406B (Cilostazol) |
| تواريخ الأحداث: | Date Created: 20121103 Date Completed: 20130620 Latest Revision: 20191027 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1590/s0102-86502012001100007 |
| PMID: | 23117610 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1678-2674 |
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| DOI: | 10.1590/s0102-86502012001100007 |