دورية أكاديمية
Determination of nimodipine in the presence of its degradation products and overall kinetics through a stability-indicating LC method.
| العنوان: | Determination of nimodipine in the presence of its degradation products and overall kinetics through a stability-indicating LC method. |
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| المؤلفون: | Riekes MK; Programa de Pós-Graduação em Farmácia, Universidade Federal de Santa Catarina, Florianópolis, SC, 88040-970, Brasil., Rauber GS, Kuminek G, Tagliari MP, Cardoso SG, Stulzer HK |
| المصدر: | Journal of chromatographic science [J Chromatogr Sci] 2013 Jul; Vol. 51 (6), pp. 511-6. Date of Electronic Publication: 2012 Nov 01. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0173225 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-239X (Electronic) Linking ISSN: 00219665 NLM ISO Abbreviation: J Chromatogr Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2012- > : Oxford : Oxford University Press Original Publication: Niles Il : Preston Technical Abstracts |
| مواضيع طبية MeSH: | Chromatography, Liquid/*methods , Nimodipine/*analysis, Analysis of Variance ; Drug Stability ; Hydrochloric Acid ; Hydrolysis ; Kinetics ; Linear Models ; Nimodipine/chemistry ; Photolysis ; Reproducibility of Results ; Sensitivity and Specificity ; Sodium Hydroxide ; Temperature |
| مستخلص: | The determination of nimodipine in the presence of its degradation products, formed through photolysis, acidic and alkaline hydrolysis, and the drug degradation kinetics under these conditions, was investigated through a validated liquid chromatography method. Separation was achieved using a Phenomenex Luna C18 column (250 × 4.6 mm i.d., 5 µm) with a mobile phase consisting of acetonitrile-methanol-water (55:11:34, v/v/v), at 0.5 mL/min and with ultraviolet detection at 235 nm. The method was considered to be specific, accurate, precise, robust and linear over the concentration range of 5.0 to 35.0 µg/mL. The drug followed a first-order reaction for both hydrolysis and photolysis in methanol, and zero-order for photolysis in acetonitrile and water. The calculated activation energies were 10.899 and 23.442 kcal/mol for alkaline and acidic hydrolysis, respectively. No degradation was observed under thermal and oxidative stress conditions. |
| المشرفين على المادة: | 55X04QC32I (Sodium Hydroxide) 57WA9QZ5WH (Nimodipine) QTT17582CB (Hydrochloric Acid) |
| تواريخ الأحداث: | Date Created: 20121103 Date Completed: 20131212 Latest Revision: 20130607 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1093/chromsci/bms174 |
| PMID: | 23118209 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1945-239X |
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| DOI: | 10.1093/chromsci/bms174 |