دورية أكاديمية
Does childhood diarrhea influence cognition beyond the diarrhea-stunting pathway?
العنوان: | Does childhood diarrhea influence cognition beyond the diarrhea-stunting pathway? |
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المؤلفون: | Fischer Walker CL; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America. cfischer@jhsph.edu, Lamberti L, Adair L, Guerrant RL, Lescano AG, Martorell R, Pinkerton RC, Black RE |
المصدر: | PloS one [PLoS One] 2012; Vol. 7 (10), pp. e47908. Date of Electronic Publication: 2012 Oct 31. |
نوع المنشور: | Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: San Francisco, CA : Public Library of Science |
مواضيع طبية MeSH: | Cognition* , Cognition Disorders*/complications , Cognition Disorders*/epidemiology , Cognition Disorders*/etiology , Diarrhea*/complications , Diarrhea*/epidemiology , Diarrhea*/physiopathology, Anthropometry ; Child ; Child, Preschool ; Female ; Humans ; Linear Models ; Male |
مستخلص: | Background: Diarrhea is a leading cause of morbidity among children under 5 years of age in low- and middle-income countries yet the additional effects and sequelae, such as cognitive impairment associated with diarrhea, have not been quantified. Methods: We quantified the association between diarrhea prevalence and cognitive outcomes while controlling for linear growth in 4 study populations. Cognition was assessed using different methods across sites and was expressed in standardized units. We built linear regression models for each study with standardized cognitive score as the outcome and diarrhea prevalence as the main predictor variable. We then conducted meta-analyses of the regression coefficients to generate pooled estimates of the association between diarrhea prevalence and cognition whilst controlling for anthropometric status and other covariates. Results: Diarrhea was not a significant predictor of cognitive score in any site in the regression models or in the meta-analyses (Coefficient = 0.07; 95% CI: -0.1, 0.2). The length for age Z- score was negatively related to cognition in all sites (0.18; 95% CI: 0.14, 0.21), with coefficients remarkably similar across sites (Coefficient Range: 0.168-0.186). Conclusions: We did not demonstrate an association between diarrhea and cognition with stunting included in the model. The links between diarrhea, stunting, and cognition provide additional rationale for accelerating interventions to reduce diarrhea. |
References: | Lancet. 2010 Jun 5;375(9730):1969-87. (PMID: 20466419) J Nutr. 1995 Aug;125(8 Suppl):2233S-2238S. (PMID: 7542705) Child Dev. 2011 Sep-Oct;82(5):1404-20. (PMID: 21790543) Int J Infect Dis. 2000;4(4):179-86. (PMID: 11231179) Int J Epidemiol. 2008 Aug;37(4):816-30. (PMID: 18567626) Indian Pediatr. 1994 Jan;31(1):55-7. (PMID: 7883322) J Am Acad Child Psychiatry. 1983 Jan;22(1):16-22. (PMID: 6402541) J Nutr. 1999 Aug;129(8):1555-62. (PMID: 10419990) Nutr Rev. 2008 Sep;66(9):487-505. (PMID: 18752473) Sci Am. 1996 Feb;274(2):38-43. (PMID: 8560214) J Child Psychol Psychiatry. 1991 Jan;32(2):307-20. (PMID: 1903401) J Nutr. 1995 Apr;125(4 Suppl):1027S-1041S. (PMID: 7536830) Child Neuropsychol. 2005 Jun;11(3):233-44. (PMID: 16036449) Pediatrics. 1990 Dec;86(6):874-82. (PMID: 2251024) Lancet. 2002 Feb 16;359(9306):564-71. (PMID: 11867110) Am J Ment Defic. 1964 Jul;69:42-9. (PMID: 14173756) Am J Trop Med Hyg. 2002 May;66(5):590-3. (PMID: 12201596) Am J Trop Med Hyg. 1999 Nov;61(5):707-13. (PMID: 10586898) Monogr Soc Res Child Dev. 1993;58(7):1-99; discussion 111-8. (PMID: 8272081) Dev Sci. 2011 Jul;14(4):832-47. (PMID: 21676102) Int J Epidemiol. 2011 Jun;40(3):619-25. (PMID: 20507864) Future Child. 2005 Spring;15(1):71-89. (PMID: 16130542) |
معلومات مُعتمدة: | 2D43 TW007393 United States TW FIC NIH HHS; D43 TW007393 United States TW FIC NIH HHS; R24 HD050924 United States HD NICHD NIH HHS; UO1AI026512 United States AI NIAID NIH HHS; U01 AI026512 United States AI NIAID NIH HHS |
تواريخ الأحداث: | Date Created: 20121103 Date Completed: 20130509 Latest Revision: 20220318 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC3485308 |
DOI: | 10.1371/journal.pone.0047908 |
PMID: | 23118906 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1932-6203 |
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DOI: | 10.1371/journal.pone.0047908 |