دورية أكاديمية
أعرض في EDS

Does childhood diarrhea influence cognition beyond the diarrhea-stunting pathway?

التفاصيل البيبلوغرافية
العنوان: Does childhood diarrhea influence cognition beyond the diarrhea-stunting pathway?
المؤلفون: Fischer Walker CL; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America. cfischer@jhsph.edu, Lamberti L, Adair L, Guerrant RL, Lescano AG, Martorell R, Pinkerton RC, Black RE
المصدر: PloS one [PLoS One] 2012; Vol. 7 (10), pp. e47908. Date of Electronic Publication: 2012 Oct 31.
نوع المنشور: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Cognition* , Cognition Disorders*/complications , Cognition Disorders*/epidemiology , Cognition Disorders*/etiology , Diarrhea*/complications , Diarrhea*/epidemiology , Diarrhea*/physiopathology, Anthropometry ; Child ; Child, Preschool ; Female ; Humans ; Linear Models ; Male
مستخلص: Background: Diarrhea is a leading cause of morbidity among children under 5 years of age in low- and middle-income countries yet the additional effects and sequelae, such as cognitive impairment associated with diarrhea, have not been quantified.
Methods: We quantified the association between diarrhea prevalence and cognitive outcomes while controlling for linear growth in 4 study populations. Cognition was assessed using different methods across sites and was expressed in standardized units. We built linear regression models for each study with standardized cognitive score as the outcome and diarrhea prevalence as the main predictor variable. We then conducted meta-analyses of the regression coefficients to generate pooled estimates of the association between diarrhea prevalence and cognition whilst controlling for anthropometric status and other covariates.
Results: Diarrhea was not a significant predictor of cognitive score in any site in the regression models or in the meta-analyses (Coefficient = 0.07; 95% CI: -0.1, 0.2). The length for age Z- score was negatively related to cognition in all sites (0.18; 95% CI: 0.14, 0.21), with coefficients remarkably similar across sites (Coefficient Range: 0.168-0.186).
Conclusions: We did not demonstrate an association between diarrhea and cognition with stunting included in the model. The links between diarrhea, stunting, and cognition provide additional rationale for accelerating interventions to reduce diarrhea.
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معلومات مُعتمدة: 2D43 TW007393 United States TW FIC NIH HHS; D43 TW007393 United States TW FIC NIH HHS; R24 HD050924 United States HD NICHD NIH HHS; UO1AI026512 United States AI NIAID NIH HHS; U01 AI026512 United States AI NIAID NIH HHS
تواريخ الأحداث: Date Created: 20121103 Date Completed: 20130509 Latest Revision: 20220318
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC3485308
DOI: 10.1371/journal.pone.0047908
PMID: 23118906
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0047908