دورية أكاديمية
Using HLA loci to inform ancestry and health in Polynesian and Maori populations.
| العنوان: | Using HLA loci to inform ancestry and health in Polynesian and Maori populations. |
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| المؤلفون: | Edinur HA; School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand., Dunn PP, Hammond L, Selwyn C, Velickovic ZM, Lea RA, Chambers GK |
| المصدر: | Tissue antigens [Tissue Antigens] 2012 Dec; Vol. 80 (6), pp. 509-22. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Blackwell Country of Publication: England NLM ID: 0331072 Publication Model: Print Cited Medium: Internet ISSN: 1399-0039 (Electronic) Linking ISSN: 00012815 NLM ISO Abbreviation: Tissue Antigens Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2015>: [Oxford] : Wiley Blackwell Original Publication: 1971- : Copenhagen, Munksgaard. |
| مواضيع طبية MeSH: | Asian People/*genetics , Ethnicity/*genetics , HLA Antigens/*genetics , Native Hawaiian or Other Pacific Islander/*genetics, Female ; Founder Effect ; Gene Flow ; Gene Frequency ; Genes, MHC Class I ; Genes, MHC Class II ; Humans ; Male ; New Zealand ; Polynesia |
| مستخلص: | Human leukocyte antigens (HLA) are important genetic markers of tissue identity and accurately reflect ancestral history. The work reported in this paper provides a detailed description of HLA polymorphism in Polynesian and Maori individuals in relation to other populations. Our study concerns HLA classes I and II antigens in Polynesian (N = 36) and Maori (N = 114) subjects genotyped at two digit resolution by New Zealand Blood Service Laboratory in Auckland using polymerase chain reaction-sequence specific oligonucleotide and PCR-SSP technologies. We have also compared our data with those from other Austronesian-speaking Mongoloid and Papuan-speaking Australoid populations in order to test previously published account of the origin of Proto-Polynesians via gender-biassed gene flow between these two ancestral populations. We use principal coordinate analysis for this purpose, arguing this approach to be superior to tree-based methods, because of factors associated with population history and admixture. Our data are in general agreement with earlier work and reflect received wisdom on the dual origin of Proto-Polynesians. They also show the way in which the genetic make-up of Polynesian and Maori subjects is changing due to intermarriage with Europeans. (© 2012 John Wiley & Sons A/S.) |
| التعليقات: | Erratum in: Tissue Antigens. 2013 Jan;81(1):60. |
| المشرفين على المادة: | 0 (HLA Antigens) |
| تواريخ الأحداث: | Date Created: 20121110 Date Completed: 20130220 Latest Revision: 20221207 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1111/tan.12026 |
| PMID: | 23137322 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1399-0039 |
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| DOI: | 10.1111/tan.12026 |