دورية أكاديمية
أعرض في EDS

Colostrum supplementation protects against exercise-induced oxidative stress in skeletal muscle in mice.

التفاصيل البيبلوغرافية
العنوان: Colostrum supplementation protects against exercise-induced oxidative stress in skeletal muscle in mice.
المؤلفون: Appukutty M; Faculty of Sports Science & Recreation, University Technology Mara, Shah Alam 40450, Kuala Lumpur, Malaysia., Radhakrishnan AK, Ramasamy K, Ramasamy R, Abdul Majeed AB, Noor MI, Safii NS, Koon PB, Chinna K, Haleagrahara N
المصدر: BMC research notes [BMC Res Notes] 2012 Nov 22; Vol. 5, pp. 649. Date of Electronic Publication: 2012 Nov 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Biomed Central Country of Publication: England NLM ID: 101462768 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-0500 (Electronic) Linking ISSN: 17560500 NLM ISO Abbreviation: BMC Res Notes Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Biomed Central, 2008.
مواضيع طبية MeSH: Dietary Supplements*, Antioxidants/*pharmacology , Colostrum/*chemistry , Muscle, Skeletal/*drug effects, Animals ; Antioxidants/chemistry ; Cattle ; Lipid Peroxidation ; Lipid Peroxides/metabolism ; Male ; Malondialdehyde/metabolism ; Mice ; Mice, Inbred BALB C ; Muscle, Skeletal/metabolism ; Oxidative Stress/drug effects ; Physical Conditioning, Animal ; Superoxide Dismutase/metabolism ; Xanthine Oxidase/metabolism
مستخلص: Background: This study examined the effects of bovine colostrum on exercise -induced modulation of antioxidant parameters in skeletal muscle in mice. Adult male BALB/c mice were randomly divided into four groups (control, colostrum alone, exercise and exercise with colostrum) and each group had three subgroups (day 0, 21 and 42). Colostrum groups of mice were given a daily oral supplement of 50 mg/kg body weight of bovine colostrum and the exercise group of mice were made to exercise on the treadmill for 30 minutes per day. Total antioxidants, lipid hydroperoxides, xanthine oxidase and super oxide dismutase level was assayed from the homogenate of hind limb skeletal muscle.
Results: Exercise-induced a significant oxidative stress in skeletal muscles as evidenced by the elevated lipid hydroperoxides and xanthine oxidase levels. There was a significant decrease in skeletal muscle total antioxidants and superoxide dismutase levels. Daily colostrum supplement significantly reduced the lipid hydroperoxides and xanthine oxidase enzyme level and increased the total antioxidant levels in the leg muscle.
Conclusion: Thus, the findings of this study showed that daily bovine colostrum supplementation was beneficial to skeletal muscle to reduce the oxidant-induced damage during muscular exercise.
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المشرفين على المادة: 0 (Antioxidants)
0 (Lipid Peroxides)
4Y8F71G49Q (Malondialdehyde)
EC 1.15.1.1 (Superoxide Dismutase)
EC 1.17.3.2 (Xanthine Oxidase)
تواريخ الأحداث: Date Created: 20121124 Date Completed: 20130621 Latest Revision: 20211021
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC3571863
DOI: 10.1186/1756-0500-5-649
PMID: 23173926
قاعدة البيانات: MEDLINE
الوصف
تدمد:1756-0500
DOI:10.1186/1756-0500-5-649