دورية أكاديمية
[Effect of Baitouweng Decoction on intestinal miR-19a expression in mice with ulcerative colitis].
| العنوان: | [Effect of Baitouweng Decoction on intestinal miR-19a expression in mice with ulcerative colitis]. |
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| المؤلفون: | Zhou P; Department of Gastroenterology, Third Affiliated Hospital of Guangzhou Medical College, Guangzhou, China., Liu F, Luo Q, Sun Y, Ding F, Chen B |
| المصدر: | Nan fang yi ke da xue xue bao = Journal of Southern Medical University [Nan Fang Yi Ke Da Xue Xue Bao] 2012 Nov; Vol. 32 (11), pp. 1597-9. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Nanfang yi ke da xue xue bao bian ji bu Country of Publication: China NLM ID: 101266132 Publication Model: Print Cited Medium: Print ISSN: 1673-4254 (Print) Linking ISSN: 16734254 NLM ISO Abbreviation: Nan Fang Yi Ke Da Xue Xue Bao Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Guangzhou : Nanfang yi ke da xue xue bao bian ji bu, 2005- |
| مواضيع طبية MeSH: | Colitis, Ulcerative/*metabolism , Drugs, Chinese Herbal/*pharmacology , MicroRNAs/*metabolism, Animals ; Colitis, Ulcerative/drug therapy ; Drugs, Chinese Herbal/therapeutic use ; Female ; Intestinal Mucosa/metabolism ; Mice ; Mice, Inbred C57BL ; Phytotherapy |
| مستخلص: | Objective: To investigate the therapeutic effect of Baitouweng Decoction on dextran sodium sulphate (DSS)-induced ulcerative colitis in mice and explore its mechanism involving miR-19a. Methods: Forty female c57 mice were randomly allocated into 4 equal groups, namely the normal control group, model group (treated with 3.5% DSS solution), treatment group (treated with DSS+Baitouweng Decoction), and positive control group (treated with DSS+5-ASA). Ulcerative colitis was induced in the mice by feeding them with 3.5% DSS in drinking water, and the mice in the control group were given water only. The disease activity index (DAI) of the mice in each group was recorded daily. Seven days later, the mice were sacrificed for histological examination of the intestines using HE staining; the expression of miR-19a mRNA in the intestines was detected using RT-qPCR. Results: Compared with the control group, the model group showed significantly increased DAI and histological scores, and administration of Baitouweng Decoction significantly lowered the DAI and histological scores of the DSS-treated mice. The expression of miR-19a was lowered following DSS treatment, and Baitouweng Decoction treatment caused an increased miR-19a expression in DSS-treated mice. Conclusion: Baitouweng Decoction has therapeutic effects on DSS-induced ulcerative colitis in mice, and this effect is probably mediated by enhancement of miR-19a expression in the intestines. |
| المشرفين على المادة: | 0 (Drugs, Chinese Herbal) 0 (MIRN190 microRNA, human) 0 (MicroRNAs) |
| تواريخ الأحداث: | Date Created: 20121124 Date Completed: 20130829 Latest Revision: 20181202 |
| رمز التحديث: | 20240628 |
| PMID: | 23174583 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1673-4254 |
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