دورية أكاديمية
Small intestine bleeding due to multifocal angiosarcoma.
العنوان: | Small intestine bleeding due to multifocal angiosarcoma. |
---|---|
المؤلفون: | Zacarias Föhrding L; Department of General, Visceral and Pediatric Surgery, Heinrich-Heine-University, Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany., Macher A, Braunstein S, Knoefel WT, Topp SA |
المصدر: | World journal of gastroenterology [World J Gastroenterol] 2012 Nov 28; Vol. 18 (44), pp. 6494-500. |
نوع المنشور: | Case Reports; Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 100883448 Publication Model: Print Cited Medium: Internet ISSN: 2219-2840 (Electronic) Linking ISSN: 10079327 NLM ISO Abbreviation: World J Gastroenterol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group Original Publication: Beijing : WJG Press, c1998- |
مواضيع طبية MeSH: | Gastrointestinal Hemorrhage/*etiology , Hemangiosarcoma/*complications , Jejunal Neoplasms/*complications, Aged, 80 and over ; Anemia/etiology ; Biomarkers, Tumor/analysis ; Biopsy ; Blood Transfusion ; Chemotherapy, Adjuvant ; Gastrointestinal Hemorrhage/therapy ; Hemangiosarcoma/chemistry ; Hemangiosarcoma/pathology ; Hemangiosarcoma/surgery ; Hemostatic Techniques ; Humans ; Jejunal Neoplasms/chemistry ; Jejunal Neoplasms/pathology ; Jejunal Neoplasms/surgery ; Jejunostomy ; Male ; Melena/etiology ; Treatment Outcome |
مستخلص: | We report a case of an 84-year-old male patient with primary small intestinal angiosarcoma. The patient initially presented with anemia and melena. Consecutive endoscopy revealed no signs of upper or lower active gastrointestinal bleeding. The patient had been diagnosed 3 years previously with an aortic dilation, which was treated with a stent. Computed tomography suggested an aorto-intestinal fistula as the cause of the intestinal bleeding, leading to operative stent explantation and aortic replacement. However, an aorto-intestinal fistula was not found, and the intestinal bleeding did not arrest postoperatively. The constant need for blood transfusions made an exploratory laparotomy imperative, which showed multiple bleeding sites, predominately in the jejunal wall. A distal loop jejunostomy was conducted to contain the small intestinal bleeding and a segmental resection for histological evaluation was performed. The histological analysis revealed a less-differentiated tumor with characteristic CD31, cytokeratin, and vimentin expression, which led to the diagnosis of small intestinal angiosarcoma. Consequently, the infiltrated part of the jejunum was successfully resected in a subsequent operation, and adjuvant chemotherapy with paclitaxel was planned. Angiosarcoma of the small intestine is an extremely rare malignant neoplasm that presents with bleeding and high mortality. Early diagnosis and treatment are essential to improve outcome. A small intestinal angiosarcoma is a challenging diagnosis to make because of its rarity, nonspecific symptoms of altered intestinal function, nonspecific abdominal pain, severe melena, and acute abdominal signs. Therefore, a quick clinical and histological diagnosis and decisive measures including surgery and adjuvant chemotherapy should be the aim. |
References: | Int J Gynecol Pathol. 1997 Oct;16(4):378-82. (PMID: 9421078) Cancer. 1970 Oct;26(4):868-83. (PMID: 5528267) Am J Gastroenterol. 1994 May;89(5):797-800. (PMID: 8172159) Cancer. 2007 Jul 1;110(1):173-8. (PMID: 17541936) Crit Rev Oncol Hematol. 2011 Nov;80(2):257-63. (PMID: 21055965) Virchows Arch. 2000 Jul;437(1):90-4. (PMID: 10963385) J Clin Oncol. 2007 Mar 1;25(7):900-1. (PMID: 17327613) Ann Afr Med. 2011 Jul-Sep;10(3):246-8. (PMID: 21912012) Cancer. 1991 May 1;67(9):2275-9. (PMID: 2013033) Cancer. 1981 Oct 15;48(8):1907-21. (PMID: 7197190) Cancer. 2012 Jul 1;118(13):3330-6. (PMID: 22045619) Sarcoma. 2005;9(3-4):161-4. (PMID: 18521426) Arch Chir Neerl. 1970;22(1):15-23. (PMID: 5310273) Am J Surg Pathol. 1998 May;22(5):620-30. (PMID: 9591733) J Cutan Pathol. 2009 Mar;36(3):362-9. (PMID: 19220634) Endoscopy. 1991 Jul;23(4):245. (PMID: 1915151) Ann Diagn Pathol. 2006 Oct;10(5):301-5. (PMID: 16979525) Ann Diagn Pathol. 2009 Jun;13(3):147-50. (PMID: 19433291) Am J Gastroenterol. 1983 Apr;78(4):218-21. (PMID: 6404159) Clin Med Insights Oncol. 2010 Oct 12;4:107-10. (PMID: 20981134) Transplant Proc. 2005 Jun;37(5):2195-9. (PMID: 15964377) APMIS. 1996 Dec;104(12):891-4. (PMID: 9048867) Int J Colorectal Dis. 1999 Dec;14(6):308-10. (PMID: 10663901) Am J Gastroenterol. 2007 Jan;102(1):89-95. (PMID: 17100969) Am J Clin Oncol. 2006 Oct;29(5):524-8. (PMID: 17023791) Hautarzt. 2008 Mar;59(3):237-48; quiz 249-50. (PMID: 18273583) Cancer. 1983 Mar 1;51(5):878-81. (PMID: 6821853) Arch Pathol Lab Med. 1988 Nov;112(11):1163-5. (PMID: 3178432) Am J Surg Pathol. 1993 Oct;17(10):959-70. (PMID: 8372948) Am J Surg Pathol. 1994 Jan;18(1):62-73. (PMID: 8279629) Medicine (Baltimore). 1979 Jan;58(1):48-64. (PMID: 368508) Cancer. 1992 Jan 15;69(2):387-95. (PMID: 1728367) Am J Surg Pathol. 2004 Mar;28(3):298-307. (PMID: 15104292) Am J Surg Pathol. 1991 Oct;15(10):915-24. (PMID: 1718176) Ulus Travma Acil Cerrahi Derg. 2010 Jul;16(4):327-33. (PMID: 20849049) Cancer. 1987 Aug 15;60(4):777-9. (PMID: 3297296) Cancer. 1988 Jul 1;62(1):210-6. (PMID: 3383117) Hepatogastroenterology. 2005 Jul-Aug;52(64):1139-42. (PMID: 16001647) Acta Cytol. 1991 Sep-Oct;35(5):538-42. (PMID: 1927194) J Gastroenterol Hepatol. 1999 Mar;14(3):289-92. (PMID: 10197502) Cancer. 1979 Dec;44(6):2044-8. (PMID: 389407) Tumori. 2001 Jul-Aug;87(4):262-5. (PMID: 11693805) Gastrointest Endosc. 2006 Dec;64(6):1018-21. (PMID: 17140922) Mod Pathol. 2000 Sep;13(9):978-87. (PMID: 11007038) Am J Cardiol. 1968 Mar;21(3):413-9. (PMID: 4230097) Ann Diagn Pathol. 2005 Oct;9(5):302-4. (PMID: 16198962) J Formos Med Assoc. 1993 Jul;92(7):658-61. (PMID: 7904504) Arch Gynecol Obstet. 2010 Jan;281(1):145-50. (PMID: 19396453) Am J Surg. 1968 Oct;116(4):548-53. (PMID: 5692131) Arch Pathol Lab Med. 2004 Jan;128(1):95-8. (PMID: 14692839) Am J Pathol. 1978 Aug;92(2):349-76. (PMID: 567014) Int J Colorectal Dis. 2008 Aug;23(8):745-56. (PMID: 18080128) Int J Radiat Oncol Biol Phys. 1999 Apr 1;44(1):113-9. (PMID: 10219803) Ann Oncol. 2012 Feb;23(2):517-23. (PMID: 21566149) Zhonghua Yi Xue Za Zhi (Taipei). 1991 Aug;48(2):147-52. (PMID: 1654187) Gastrointest Endosc Clin N Am. 1996 Oct;6(4):709-38. (PMID: 8899404) World J Surg Oncol. 2012 Jan 26;10:23. (PMID: 22280556) Chest. 1993 May;103(5):1531-5. (PMID: 8486039) Pathol Int. 1997 Aug;47(8):553-6. (PMID: 9293536) Diagn Cytopathol. 2010 Feb;38(2):154-8. (PMID: 19813270) CA Cancer J Clin. 2007 Jan-Feb;57(1):43-66. (PMID: 17237035) Cardiovasc Pathol. 2010 May-Jun;19(3):e69-74. (PMID: 19150248) Med Oncol. 2003;20(4):397-402. (PMID: 14716038) |
فهرسة مساهمة: | Keywords: Angiosarcoma; Gastrointestinal bleeding; Small intestinal neoplasm; Small intestine |
المشرفين على المادة: | 0 (Biomarkers, Tumor) |
تواريخ الأحداث: | Date Created: 20121201 Date Completed: 20131114 Latest Revision: 20211021 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC3508646 |
DOI: | 10.3748/wjg.v18.i44.6494 |
PMID: | 23197897 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2219-2840 |
---|---|
DOI: | 10.3748/wjg.v18.i44.6494 |