دورية أكاديمية
Pre-treatment with curcumin modulates acetylcholinesterase activity and proinflammatory cytokines in rats infected with Trypanosoma evansi.
| العنوان: | Pre-treatment with curcumin modulates acetylcholinesterase activity and proinflammatory cytokines in rats infected with Trypanosoma evansi. |
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| المؤلفون: | Wolkmer P; Department of Chemistry, Universidade Federal de Santa Maria, Brazil. patiwol@hotmail.com, Silva CB, Paim FC, Duarte MM, Castro V, Palma HE, França RT, Felin DV, Siqueira LC, Lopes ST, Schetinger MR, Monteiro SG, Mazzanti CM |
| المصدر: | Parasitology international [Parasitol Int] 2013 Apr; Vol. 62 (2), pp. 144-9. Date of Electronic Publication: 2012 Nov 29. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9708549 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-0329 (Electronic) Linking ISSN: 13835769 NLM ISO Abbreviation: Parasitol Int Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier, c1997- |
| مواضيع طبية MeSH: | Acetylcholinesterase/*blood , Anti-Inflammatory Agents, Non-Steroidal/*pharmacology , Curcumin/*pharmacology , Cytokines/*blood , Immunologic Factors/*pharmacology , Trypanosomiasis/*immunology, Acetylcholinesterase/metabolism ; Administration, Oral ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/therapeutic use ; Curcumin/administration & dosage ; Curcumin/therapeutic use ; Cytokines/metabolism ; Disease Models, Animal ; Immunologic Factors/therapeutic use ; Male ; Parasitemia ; Random Allocation ; Rats ; Rats, Wistar ; Trypanosoma/drug effects ; Trypanosoma/immunology ; Trypanosomiasis/drug therapy ; Trypanosomiasis/enzymology ; Trypanosomiasis/prevention & control |
| مستخلص: | The potent activity against Trypanosomes and health beneficial effects of curcumin (Cur) has been demonstrated in various experimental models. In this study, we evaluated the in vivo effect of Cur as trypanocide and as potential anti-inflammatory agent, through the evaluation of immunomodulatory mechanisms in rats infected with Trypanosoma evansi. Daily oral Cur was administered at doses of 0, 20 or 60mg/kg as preventive treatment (30 and 15days pre infection) and as treatment (post infection). The treatment of the groups continued until the day of euthanasia. Fifteen days after inoculation, parasitemia, plasma proinflammatory cytokines (IFN-γ, TNF-α, IL-1, IL-6), anti-inflammatory cytokines (IL-10) and blood acetylcholinesterase activity (AChE) were analyzed. Pretreatment with Cur reduced parasitemia and lethality. Cur inhibited AChE activity and improved immunological response by cytokines proinflammatory, fundamental during T. evansi infection. We found that Cur is not so important as an antitrypanosomal activity but as immunomodulator agent. These findings reveal that the preventive use of Cur stimulates anti-inflammatory mechanisms, reducing an excessive inflammatory response. (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.) |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents, Non-Steroidal) 0 (Cholinesterase Inhibitors) 0 (Cytokines) 0 (Immunologic Factors) EC 3.1.1.7 (Acetylcholinesterase) IT942ZTH98 (Curcumin) |
| تواريخ الأحداث: | Date Created: 20121204 Date Completed: 20130916 Latest Revision: 20131121 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.parint.2012.11.004 |
| PMID: | 23200738 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1873-0329 |
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| DOI: | 10.1016/j.parint.2012.11.004 |