دورية أكاديمية
Sentinel lymph node biopsy in patients with locally advanced breast cancer after neoadjuvant chemotherapy.
| العنوان: | Sentinel lymph node biopsy in patients with locally advanced breast cancer after neoadjuvant chemotherapy. |
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| المؤلفون: | Aguiar PH; Department of Mastology, Walter Cantidio University Hospital, UFC, Fortaleza, CE, Brazil., Pinheiro LG, Mota RM, Margotti NH, Rocha JI |
| المصدر: | Acta cirurgica brasileira [Acta Cir Bras] 2012 Dec; Vol. 27 (12), pp. 912-6. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sociedade Brasileira Para O Desenvolvimento Da Pesquisa Em Cirurgia Curso De Pos-Graduacao Em Tecnica Operatoria E Cirurgia Experimental Escola Paulista De Medicina Country of Publication: Brazil NLM ID: 9103983 Publication Model: Print Cited Medium: Internet ISSN: 1678-2674 (Electronic) Linking ISSN: 01028650 NLM ISO Abbreviation: Acta Cir Bras Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Sao Paulo : Sociedade Brasileira Para O Desenvolvimento Da Pesquisa Em Cirurgia Curso De Pos-Graduacao Em Tecnica Operatoria E Cirurgia Experimental Escola Paulista De Medicina Original Publication: São Paulo : A Sociedade, |
| مواضيع طبية MeSH: | Neoadjuvant Therapy*, Breast Neoplasms/*pathology , Lymph Nodes/*pathology , Sentinel Lymph Node Biopsy/*methods, Adult ; Aged ; Axilla ; Breast Neoplasms/drug therapy ; Breast Neoplasms/surgery ; Chemotherapy, Adjuvant/methods ; Cross-Sectional Studies ; False Negative Reactions ; Female ; Humans ; Lymph Nodes/surgery ; Lymphatic Metastasis ; Middle Aged |
| مستخلص: | Purpose: To check the rate of sentinel lymph node (SLN) identification in patients with locally advanced breast cancer who underwent neoadjuvant chemotherapy comparing intraoperative contact cytology (imprint) and embedded in paraffin and validation of methods. Methods: A cross-sectional validation of diagnostic test involving 34 patients from the outpatient clinic of the Maternity School Assis Chateaubriand. The patients had locally advanced breast cancer and were treated with neoadjuvant chemotherapy. Those with clinically negative axilla underwent SLN biopsy, studied by imprint and histopathology in paraffin. All patients underwent axillary dissection and its histopathological study. Results: The SLN identification rate was 85.3% (29/34). The sensitivity of imprint associated with paraffin on detection of metastasis compared to histopathology of the axillary content was 84.62% and specificity of 100% with false-negative rate of 12.01% and an accuracy of 92.77%. Conclusion: The search for metastases in the SLN by imprint and histopathological analysis in paraffin compared to the gold standard (axillary dissection) had a low sensitivity with high rate of false negatives in our sample. |
| تواريخ الأحداث: | Date Created: 20121205 Date Completed: 20130926 Latest Revision: 20191027 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1590/s0102-86502012001200014 |
| PMID: | 23207760 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1678-2674 |
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| DOI: | 10.1590/s0102-86502012001200014 |