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Toxicological assessment of β-(1-->6)-glucan (lasiodiplodan) in mice during a 28-day feeding study by gavage.

التفاصيل البيبلوغرافية
العنوان: Toxicological assessment of β-(1-->6)-glucan (lasiodiplodan) in mice during a 28-day feeding study by gavage.
المؤلفون: Túrmina JA; Pharmaceutical Science and Biodiversity Postgraduate Programs, Midwest State University, Campus CEDETEG, Guarapuava, PR 85040-080, Brazil., Carraro E, Alves da Cunha MA, Dekker RF, Barbosa AM, Dos Santos FS, Silva LA, Malfatti CR
المصدر: Molecules (Basel, Switzerland) [Molecules] 2012 Dec 03; Vol. 17 (12), pp. 14298-309. Date of Electronic Publication: 2012 Dec 03.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Heart*/drug effects , Kidney*/drug effects , Kidney*/pathology , Liver*/drug effects , Liver*/pathology , Spleen*/drug effects , Spleen*/pathology , beta-Glucans*/administration & dosage , beta-Glucans*/toxicity, Animals ; Dose-Response Relationship, Drug ; Female ; Humans ; Intubation, Gastrointestinal ; Male ; Mice
مستخلص: Studies evaluating the toxicity caused by fungal exopolysaccharides of the β-(1-->6)-D-glucan type are rare. In this study, the toxicological effects of sub-chronic treatments with lasiodiplodan (β-(1-->6)-D-glucan from Lasiodiplodia theobromae MMPI) were evaluated in mice through the assessment of biochemical, hematological, and histopathological alterations. Thirty-two mice (16 male, 16 female) were used in this study divided in two groups; one group received lasiodiplodan (50 mg/kg body weight) daily for 28 days via gavage, and another (control group) received saline during the same period. Blood samples were collected via cardiac puncture for hematological and biochemical analyses. Liver, heart, kidney, and spleen were collected for histopathological analysis. Statistical analysis was performed through one-way analysis of variance and only p < 0.05 F-values were presented. Significant reduction in blood glucose in the male group (35%; p < 0.01), transaminases activity in both sexes (AST and ALT; ~35%; p < 0.05), and urea (20%; p < 0.01) in the female group was observed with the lasiodiplodan treatment. The results showed that sub-chronic treatments with lasiodiplodan did not generate hematological and histopathological alterations leading to signs of toxicity in healthy mice, independent of gender.
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المشرفين على المادة: 0 (beta-Glucans)
تواريخ الأحداث: Date Created: 20121205 Date Completed: 20130530 Latest Revision: 20231004
رمز التحديث: 20231004
مُعرف محوري في PubMed: PMC6268985
DOI: 10.3390/molecules171214298
PMID: 23208465
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules171214298