دورية أكاديمية
أعرض في EDS

Effect of Sanqi Oral Liquid on the expressions of CD4⁺, CD8⁺ and CD68⁺ cells in 5/6 nephrectomized rats with chronic renal failure.

التفاصيل البيبلوغرافية
العنوان: Effect of Sanqi Oral Liquid on the expressions of CD4⁺, CD8⁺ and CD68⁺ cells in 5/6 nephrectomized rats with chronic renal failure.
المؤلفون: Wei FN; Department of Urology, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, China., Chen ZL, Yang HF, Han L, Ding HM, Deng SG, Ou RM, Ou AH, Liang YF, Hu ZH, Wang J, Yang XH, Yang NZ
المصدر: Chinese journal of integrative medicine [Chin J Integr Med] 2013 Aug; Vol. 19 (8), pp. 589-95. Date of Electronic Publication: 2012 Dec 03.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Chinese Journal of Integrated Traditional and Western Medicine Press Country of Publication: China NLM ID: 101181180 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1672-0415 (Print) Linking ISSN: 16720415 NLM ISO Abbreviation: Chin J Integr Med Subsets: MEDLINE
أسماء مطبوعة: Publication: 2007- : Berlin : Chinese Journal of Integrated Traditional and Western Medicine Press : Springer
Original Publication: Beijing, China : Watertown, MA : Chinese Association of the Integration of Traditional and Western Medicine : China Academy of Traditional Chinese Medicine ; Distributed by Relaxing Natural Health, [2003]-
مواضيع طبية MeSH: CD4-Positive T-Lymphocytes/*drug effects , CD8-Positive T-Lymphocytes/*drug effects , Drugs, Chinese Herbal/*pharmacology , Kidney Failure, Chronic/*drug therapy, Administration, Oral ; Animals ; Antigens, CD/metabolism ; Antigens, Differentiation, Myelomonocytic/metabolism ; Astragalus propinquus/chemistry ; CD4-Positive T-Lymphocytes/pathology ; CD4-Positive T-Lymphocytes/physiology ; CD8-Positive T-Lymphocytes/pathology ; CD8-Positive T-Lymphocytes/physiology ; Drug Evaluation, Preclinical ; Drugs, Chinese Herbal/administration & dosage ; Kidney Failure, Chronic/immunology ; Kidney Failure, Chronic/pathology ; Kidney Failure, Chronic/surgery ; Lymphocyte Count ; Male ; Nephrectomy ; Panax notoginseng/chemistry ; Rats ; Rats, Sprague-Dawley ; Solutions
مستخلص: Objective: To explore the mechanisms of Chinese herbal medicine Sanqi Oral Liquid, composed of Astragalus membranaceus and Panpax notoginseng, in alleviating renal injury by observing its effect on the expressions of CD4(+), CD8(+) and CD68(+) cells in 5/6 nephrectomized rats with chronic renal failure.
Methods: A total of 102 SD rats were randomly divided into six groups: three treatment groups were administrated with high, medium and low dosage of Sanqi Oral Liquid respectively by gavage; a normal group, a 5/6 nephrectomized model group, and a group treated with coated aldehyde oxygenstarch were used as controls. Following oral administration of Sanqi Oral Liquid for 12 weeks, the general condition and renal pathological changes were observed, and the renal function, platelet count (PLT) and the expressions of CD4(+), CD8(+) and CD68(+) cells were determined for each group.
Results: There were proliferation of mesangial matrix, renaltubularnecrosis and obvious tubulointerstitial fibrosis in the model group, and they were much milder in the treatment groups. Compared with the model group, the amounts of blood urea nitrogen (BUN), serum creatinine (Scr) and PLT in the treatment groups decreased (P<0.05 for all); and in the group administrated of medium dosage of Sanqi Oral Liquid, the expression of CD4(+) cells was up-regulated and those of CD8(+) and CD68(+) cells were down-regulated (P<0.05 for all), leading to an increased ratio of CD4(+)/CD8(+)(P<0.01).
Conclusion: Sanqi Oral Liquid has a significant effect on regulating lymphocyte subsets, reducing the infiltration of macrophages in renal tissues and alleviating tubulointerstitial fibrosis, and this may be one of mechanisms of Sanqi Oral Liquid in delaying the progression of chronic kidney diseases.
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المشرفين على المادة: 0 (Antigens, CD)
0 (Antigens, Differentiation, Myelomonocytic)
0 (CD68 protein, rat)
0 (Drugs, Chinese Herbal)
0 (Solutions)
0 (sanqi)
تواريخ الأحداث: Date Created: 20121206 Date Completed: 20140407 Latest Revision: 20211021
رمز التحديث: 20221213
DOI: 10.1007/s11655-012-1233-5
PMID: 23212567
قاعدة البيانات: MEDLINE
الوصف
تدمد:1672-0415
DOI:10.1007/s11655-012-1233-5