دورية أكاديمية
أعرض في EDS

Pubertal immune challenge blocks the ability of estradiol to enhance performance on cognitive tasks in adult female mice.

التفاصيل البيبلوغرافية
العنوان: Pubertal immune challenge blocks the ability of estradiol to enhance performance on cognitive tasks in adult female mice.
المؤلفون: Ismail N; Center for Neuroendocrine Studies, School of Psychology, University of Ottawa, Vanier Hall, Ottawa, ON, Canada. nafissa.ismail@uottawa.ca, Blaustein JD
المصدر: Psychoneuroendocrinology [Psychoneuroendocrinology] 2013 Jul; Vol. 38 (7), pp. 1170-7. Date of Electronic Publication: 2012 Dec 04.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 7612148 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3360 (Electronic) Linking ISSN: 03064530 NLM ISO Abbreviation: Psychoneuroendocrinology Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford, Elmsford, N. Y., Pergamon Press.
مواضيع طبية MeSH: Cognition/*physiology , Discrimination, Psychological/*physiology , Estradiol/*pharmacology , Recognition, Psychology/*physiology , Sexual Maturation/*immunology, Animals ; Cognition/drug effects ; Discrimination, Psychological/drug effects ; Female ; Lipopolysaccharides/pharmacology ; Mice ; Recognition, Psychology/drug effects ; Sexual Maturation/drug effects ; Social Behavior
مستخلص: Puberty is a period characterized by brain reorganization that contributes to the development of neural and behavioral responses to gonadal steroids. Previously, we have shown that a single injection of the bacterial endotoxin, lipopolysaccharide (LPS; 1.5mg/kg IP), during the pubertal period (around 6weeks old) in mice decreases sexual receptivity in response to estradiol and progesterone in adulthood. These findings suggest that pubertal immune challenge has an enduring effect of decreasing the behavioral responsiveness to gonadal steroid hormones. Since estradiol improves cognitive function in certain tasks in mice, we investigated the effect of pubertal immune challenge on the ability of estradiol to enhance cognitive function. We hypothesized that estradiol would be less effective at enhancing performance on particular cognitive tasks in female mice treated with LPS during puberty. Six-week old (pubertal) and 10-week old (adult) female CD1 mice were injected with either saline or LPS. Five weeks later, they were ovariectomized and implanted subcutaneously with either an estradiol- or oil-filled Silastic(©) capsule followed 1week later with testing for cognitive function. The duration of juvenile investigation during social discrimination and recognition tests was used as a measure of social memory, and the duration of object investigation during object recognition and placement tests was used as a measure of object memory. Chronic estradiol treatment enhanced social and object memory in saline-treated females and in females treated with LPS in adulthood. In contrast, in females treated with LPS at 6weeks old, estradiol failed to improve social and object memories. These results support the hypothesis that exposure to an immune challenge during puberty reduces at least some of the cognitive effects of estradiol. Moreover, these results support the idea that pubertal immune challenge compromises a wide variety of behavioral influences of ovarian hormones.
(Published by Elsevier Ltd.)
References: Fertil Steril. 1973 Jul;24(7):546-52. (PMID: 4715229)
Neurobiol Learn Mem. 2005 Sep;84(2):132-7. (PMID: 16054404)
Arch Dis Child. 1969 Jun;44(235):291-303. (PMID: 5785179)
Brain Behav Immun. 2008 May;22(4):573-89. (PMID: 18191534)
Front Neuroendocrinol. 2012 Oct;33(4):388-402. (PMID: 22981654)
Front Neuroendocrinol. 2008 May;29(2):219-37. (PMID: 18078984)
Endocrinology. 2003 Jul;144(7):2836-44. (PMID: 12810538)
Physiol Behav. 1995 Aug;58(2):315-21. (PMID: 7568435)
Behav Neurosci. 2002 Jun;116(3):411-20. (PMID: 12049322)
Behav Brain Res. 2008 Jan 25;186(2):230-8. (PMID: 17884190)
Sci Total Environ. 2005 Jun 15;346(1-3):1-16. (PMID: 15993678)
Peptides. 2004 Sep;25(9):1565-74. (PMID: 15374658)
Horm Behav. 2011 Sep;60(4):318-26. (PMID: 21722643)
Neurobiol Aging. 2002 Jul-Aug;23(4):589-600. (PMID: 12009508)
Horm Behav. 2002 Dec;42(4):484-91. (PMID: 12488114)
Brain Cogn. 2010 Feb;72(1):66-72. (PMID: 19942334)
Endocrinology. 2009 Aug;150(8):3717-25. (PMID: 19372198)
Horm Behav. 2004 Feb;45(2):128-35. (PMID: 15019800)
Exp Brain Res. 1993;93(2):299-306. (PMID: 8491268)
Brain Res. 2000 Nov 17;883(2):258-64. (PMID: 11074057)
Endocrinology. 2009 May;150(5):2351-8. (PMID: 19131570)
N Engl J Med. 1998 Jan 22;338(4):209-16. (PMID: 9435325)
Cell Mol Neurobiol. 2012 Jul;32(5):725-35. (PMID: 22113371)
Neuroscience. 2013 Sep 26;249:43-52. (PMID: 23036617)
Physiol Behav. 2009 May 25;97(2):146-50. (PMID: 19258019)
Hippocampus. 2001;11(2):176-86. (PMID: 11345124)
Neurobiol Learn Mem. 1997 Sep;68(2):172-88. (PMID: 9322259)
Neurobiol Learn Mem. 2012 May;97(4):418-24. (PMID: 22452926)
Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2185-90. (PMID: 14766964)
Horm Behav. 1998 Oct;34(2):149-62. (PMID: 9799625)
J Neurosci. 1992 Jul;12(7):2549-54. (PMID: 1613547)
Horm Behav. 2009 May;55(5):597-604. (PMID: 19446076)
Neurobiol Learn Mem. 2004 Nov;82(3):309-23. (PMID: 15464412)
Neuron. 2003 Jun 19;38(6):987-96. (PMID: 12818183)
Horm Behav. 1997 Dec;32(3):217-25. (PMID: 9454673)
Brain Behav Immun. 2007 May;21(4):477-89. (PMID: 17267173)
J Pediatr. 2003 Oct;143(4 Suppl):S35-45. (PMID: 14597912)
J Neurosci. 2003 Jul 2;23(13):5708-14. (PMID: 12843274)
Biochim Biophys Acta. 2010 Oct;1800(10):1056-67. (PMID: 20100545)
Horm Behav. 2011 Apr;59(4):565-71. (PMID: 21376052)
Mol Cell Endocrinol. 2006 Jul 25;254-255:120-6. (PMID: 16753257)
Life Sci. 2006 Sep 13;79(16):1553-60. (PMID: 16750837)
J Neurosci. 2000 Dec 1;20(23):8853-60. (PMID: 11102494)
معلومات مُعتمدة: R21 MH093854 United States MH NIMH NIH HHS; MH 093854 United States MH NIMH NIH HHS
المشرفين على المادة: 0 (Lipopolysaccharides)
4TI98Z838E (Estradiol)
تواريخ الأحداث: Date Created: 20121211 Date Completed: 20131230 Latest Revision: 20211021
رمز التحديث: 20240513
مُعرف محوري في PubMed: PMC3604046
DOI: 10.1016/j.psyneuen.2012.11.003
PMID: 23218519
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-3360
DOI:10.1016/j.psyneuen.2012.11.003