دورية أكاديمية
Association between C-reactive protein and homocysteine with the subcomponents of metabolic syndrome in stable patients with bipolar disorder and schizophrenia.
| العنوان: | Association between C-reactive protein and homocysteine with the subcomponents of metabolic syndrome in stable patients with bipolar disorder and schizophrenia. |
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| المؤلفون: | Vuksan-Cusa B; Department of Psychiatry, University Hospital Center Zagreb , Zagreb , Croatia., Sagud M, Jakovljevic M, Peles AM, Jaksic N, Mihaljevic S, Zivkovic M, Mikulic SK, Jevtovic S |
| المصدر: | Nordic journal of psychiatry [Nord J Psychiatry] 2013 Oct; Vol. 67 (5), pp. 320-5. Date of Electronic Publication: 2012 Dec 11. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 100927567 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1502-4725 (Electronic) Linking ISSN: 08039488 NLM ISO Abbreviation: Nord J Psychiatry Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Oslo ; Boston : Scandinavian University Press, c1999- |
| مواضيع طبية MeSH: | Bipolar Disorder/*blood , C-Reactive Protein/*analysis , Homocysteine/*blood , Metabolic Syndrome/*blood , Schizophrenia/*blood, Adult ; Antipsychotic Agents/therapeutic use ; Bipolar Disorder/complications ; Bipolar Disorder/drug therapy ; Cardiovascular Diseases/etiology ; Female ; Humans ; Male ; Metabolic Syndrome/complications ; Middle Aged ; Risk Factors ; Schizophrenia/complications ; Schizophrenia/drug therapy |
| مستخلص: | Background: Previous studies revealed high prevalence of metabolic syndrome (MetS) in patients with bipolar disorder and schizophrenia. C-Reactive protein (CRP) and homocysteine have also both emerged as independent risk factors for the development of cardiovascular disease (CVD) but are less investigated in psychiatric disorders. Aims: The aim of this study was to ascertain which specific subcomponents of MetS are associated with levels of CRP and homocysteine in patients with bipolar disorder and schizophrenia. Methods: Our sample consisted of patient group (n = 122) (60 bipolar and 62 schizophrenic patients) treated with second-generation antipsychotics (SGA) and healthy controls (n = 59). MetS was defined according to NCEP ATP-III criteria; the cut-off point for elevated CRP was set up at 5 mg/l and for hyperhomocysteinemia at 15 μmol/l. Results: In the patient group, homocysteine was correlated with waist circumference, systolic and diastolic blood pressure, triglycerides and blood glucose, while CRP was correlated with waist circumference and diastolic blood pressure. Patients with hyperhomocysteinemia had an 8.442 times higher chance to have met the criteria for MetS while elevated CRP was not a significant predictor of MetS. Conclusions: There is a complex association between CRP and homocysteine with specific subcomponents of MetS in patients with bipolar disorder and schizophrenia. Given the high risk of cardiovascular disorders in psychiatric patients, these relationships deserve further investigation. Clinically, it could be useful to include the measurement of homocysteine and CRP levels in routine psychiatric diagnostic procedures. |
| المشرفين على المادة: | 0 (Antipsychotic Agents) 0LVT1QZ0BA (Homocysteine) 9007-41-4 (C-Reactive Protein) |
| تواريخ الأحداث: | Date Created: 20121212 Date Completed: 20140401 Latest Revision: 20181202 |
| رمز التحديث: | 20240628 |
| DOI: | 10.3109/08039488.2012.745601 |
| PMID: | 23228159 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1502-4725 |
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| DOI: | 10.3109/08039488.2012.745601 |