دورية أكاديمية
أعرض في EDS

Ischaemia-reperfusion injury in liver transplantation--from bench to bedside.

التفاصيل البيبلوغرافية
العنوان: Ischaemia-reperfusion injury in liver transplantation--from bench to bedside.
المؤلفون: Zhai Y; The Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at UCLA, 77-120 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA., Petrowsky H, Hong JC, Busuttil RW, Kupiec-Weglinski JW
المصدر: Nature reviews. Gastroenterology & hepatology [Nat Rev Gastroenterol Hepatol] 2013 Feb; Vol. 10 (2), pp. 79-89. Date of Electronic Publication: 2012 Dec 11.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101500079 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1759-5053 (Electronic) Linking ISSN: 17595045 NLM ISO Abbreviation: Nat Rev Gastroenterol Hepatol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London ; New York : Nature Pub. Group, c2009-
مواضيع طبية MeSH: Liver/*blood supply , Liver Transplantation/*physiology , Reperfusion Injury/*physiopathology, Adaptive Immunity/physiology ; Animals ; Humans ; Immunity, Innate/physiology ; Liver/physiopathology ; Liver/surgery ; Models, Animal ; Signal Transduction/physiology ; Swine
مستخلص: Ischaemia-reperfusion injury (IRI) in the liver, a major complication of haemorrhagic shock, resection and transplantation, is a dynamic process that involves the two interrelated phases of local ischaemic insult and inflammation-mediated reperfusion injury. This Review highlights the latest mechanistic insights into innate-adaptive immune crosstalk and cell activation cascades that lead to inflammation-mediated injury in livers stressed by ischaemia-reperfusion, discusses progress in large animal experiments and examines efforts to minimize liver IRI in patients who have received a liver transplant. The interlinked signalling pathways in multiple hepatic cell types, the IRI kinetics and positive versus negative regulatory loops at the innate-adaptive immune interface are discussed. The current gaps in our knowledge and the pathophysiology aspects of IRI in which basic and translational research is still required are stressed. An improved appreciation of cellular immune events that trigger and sustain local inflammatory responses, which are ultimately responsible for organ injury, is fundamental to developing innovative strategies for treating patients who have received a liver transplant and developed ischaemia-reperfusion inflammation and organ dysfunction.
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معلومات مُعتمدة: R01 DK083408 United States DK NIDDK NIH HHS
تواريخ الأحداث: Date Created: 20121212 Date Completed: 20130830 Latest Revision: 20220408
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC3577927
DOI: 10.1038/nrgastro.2012.225
PMID: 23229329
قاعدة البيانات: MEDLINE
الوصف
تدمد:1759-5053
DOI:10.1038/nrgastro.2012.225