دورية أكاديمية
The tanapoxvirus 15L protein is a virus-encoded neuregulin that promotes viral replication in human endothelial cells.
| العنوان: | The tanapoxvirus 15L protein is a virus-encoded neuregulin that promotes viral replication in human endothelial cells. |
|---|---|
| المؤلفون: | Jeng D; Department of Biological Sciences, Western Michigan University, Kalamazoo, MI, USA., Ma Z, Barrett JW, McFadden G, Loeb JA, Essani K |
| المصدر: | Journal of virology [J Virol] 2013 Mar; Vol. 87 (6), pp. 3018-26. Date of Electronic Publication: 2012 Dec 26. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington Dc : American Society For Microbiology Original Publication: Baltimore, American Society for Microbiology. |
| مواضيع طبية MeSH: | Virus Replication*, Endothelial Cells/*virology , Neuregulins/*metabolism , Viral Proteins/*metabolism , Virulence Factors/*metabolism , Yatapoxvirus/*pathogenicity, Amino Acid Sequence ; Animals ; Cell Line ; Gene Knockout Techniques ; Humans ; Molecular Sequence Data ; Neuregulins/genetics ; Sequence Alignment ; Viral Proteins/genetics ; Virulence Factors/genetics ; Yatapoxvirus/physiology |
| مستخلص: | Studies on large double-stranded DNA (dsDNA) viruses such as poxviruses have been helpful in identifying a number of viral and cellular growth factors that contribute to our broad understanding of virus-host interaction. Orthopoxviruses and leporipoxviruses are among the most studied viruses in this aspect. However, tanapoxvirus (TPV), a member of the genus Yatapoxvirus, still remains largely unexplored, as the only known hosts for this virus are humans and monkeys. Here, we describe the initial characterization of an epidermal growth factor (EGF)-like growth factor mimicking human neuregulin from TPV, expressed by the TPV-15L gene. Assays using a baculovirus-expressed and tagged TPV-15L protein demonstrated the ability to phosphorylate neuregulin receptors. Neuregulins represent a large family of EGF-like growth factors that play important roles in embryonic endocardium development, Schwann and oligodendrocyte survival and differentiation, localized acetylcholine receptor expression at the neuromuscular junction, and epithelial morphogenesis. Interestingly, certain neuregulin molecules are able to target specific tissues through interactions with heparin sulfate proteoglycans via an immunoglobulin (Ig)-like domain. Analyses of TPV-15L revealed no Ig-like domain, but it retains the ability to bind heparin and phosphorylate neuregulin receptors, providing compelling evidence that TPV-15L is a functional mimetic of neuregulin. TPV-15L knockout virus experiments demonstrate that the virus replicates in human umbilical vein endothelial cells less efficiently than wild-type TPV-Kenya, indicating that this is a nonessential protein for virus viability but can serve a stimulatory role for replication in some cultured cells. However, the precise role of this protein in host-virus interaction still remains to be deduced. |
| References: | J Biol Chem. 2004 Jun 11;279(24):25838-48. (PMID: 15070899) Transplant Proc. 1996 Aug;28(4):2085-8. (PMID: 8769162) J Cell Biol. 1995 Jul;130(1):127-35. (PMID: 7540614) J Biol Chem. 2005 Jan 7;280(1):383-8. (PMID: 15528194) Virology. 2001 Mar 15;281(2):170-92. (PMID: 11277691) EMBO J. 1998 Oct 15;17(20):5948-63. (PMID: 9774339) J Biol Chem. 2009 Nov 13;284(46):32108-15. (PMID: 19717564) Virology. 1994 Jun;201(2):215-40. (PMID: 8184534) Brain Res Rev. 2006 Aug;51(2):161-75. (PMID: 16412517) Microb Pathog. 1998 Jul;25(1):33-41. (PMID: 9705247) Nature. 1985 Feb 7-13;313(6002):491-2. (PMID: 3871510) Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4831-6. (PMID: 12676996) J Biol Chem. 1996 Mar 1;271(9):5251-7. (PMID: 8617810) J Cell Biol. 1998 May 4;141(3):715-26. (PMID: 9566971) Am J Physiol. 1999 Dec;277(6):H2205-11. (PMID: 10600838) J Clin Oncol. 1996 Mar;14(3):737-44. (PMID: 8622019) J Virol. 1988 Mar;62(3):866-74. (PMID: 3339716) Virus Res. 2007 Oct;129(1):11-25. (PMID: 17574698) Cell. 1993 Mar 12;72(5):801-15. (PMID: 8453670) Microb Pathog. 1994 Nov;17(5):347-53. (PMID: 7723661) Arch Biochem Biophys. 1997 Jul 1;343(1):92-100. (PMID: 9210650) J Biol Chem. 2001 Oct 12;276(41):38068-75. (PMID: 11502740) Virology. 1988 May;164(1):182-92. (PMID: 3363864) Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):8972-6. (PMID: 8105469) Cytokine Growth Factor Rev. 2008 Apr;19(2):173-81. (PMID: 18295531) J Virol. 2003 Dec;77(24):13335-47. (PMID: 14645589) Virology. 1990 Dec;179(2):926-30. (PMID: 2173269) Nature. 1985 Jul 18-24;316(6025):219-20. (PMID: 2991765) Can J Microbiol. 1999 Jan;45(1):92-6. (PMID: 10349725) J Biol Chem. 1990 Nov 5;265(31):18884-90. (PMID: 2229050) Recent Pat DNA Gene Seq. 2011 Aug;5(2):97-103. (PMID: 21529335) Br Med J. 1971 Feb 13;1(5745):363-8. (PMID: 5541925) Proc Natl Acad Sci U S A. 1988 Jul;85(14):5102-6. (PMID: 2899323) Proc Natl Acad Sci U S A. 1984 Dec;81(23):7363-7. (PMID: 6334307) J Virol. 2002 Jun;76(12):6054-61. (PMID: 12021338) Mol Cell Neurosci. 2004 Aug;26(4):558-69. (PMID: 15276157) Development. 1999 Feb;126(4):781-91. (PMID: 9895325) Proc Natl Acad Sci U S A. 1985 Aug;82(16):5300-4. (PMID: 3875097) Neuron. 1997 Jun;18(6):847-55. (PMID: 9208852) J Virol. 2001 Aug;75(15):7122-30. (PMID: 11435593) Annu Rev Immunol. 2003;21:377-423. (PMID: 12543935) Biochemistry. 1991 Apr 2;30(13):3310-4. (PMID: 2009268) Virus Genes. 1999;18(2):151-60. (PMID: 10403701) Cell Struct Funct. 2006;31(1):15-27. (PMID: 16557002) J Biol Chem. 2000 Jan 7;275(1):557-64. (PMID: 10617651) J Gen Virol. 1993 Sep;74 ( Pt 9):1725-40. (PMID: 7690839) Mol Biol Cell. 1995 Aug;6(8):967-80. (PMID: 7579712) Nature. 1985 Feb 28-Mar 6;313(6005):801-3. (PMID: 3871916) |
| معلومات مُعتمدة: | R01 NS059947 United States NS NINDS NIH HHS; R15 CA156262 United States CA NCI NIH HHS; R01NS059947 United States NS NINDS NIH HHS; 1R15CA156262-01 United States CA NCI NIH HHS |
| المشرفين على المادة: | 0 (Neuregulins) 0 (Viral Proteins) 0 (Virulence Factors) |
| تواريخ الأحداث: | Date Created: 20121228 Date Completed: 20130417 Latest Revision: 20211021 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC3592142 |
| DOI: | 10.1128/JVI.02112-12 |
| PMID: | 23269801 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1098-5514 |
|---|---|
| DOI: | 10.1128/JVI.02112-12 |