دورية أكاديمية
Iron metabolism and its relationship to anemia and immune system in Trypanosoma evansi infected rats.
| العنوان: | Iron metabolism and its relationship to anemia and immune system in Trypanosoma evansi infected rats. |
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| المؤلفون: | da Silva CB; Department of Small Animals, Universidade Federal de Santa Maria, Brazil. cassiabagolin@hotmail.com, Wolkmer P, Paim FC, Da Silva AS, Siqueira LC, de Souza CL, França RT, Dornelles GL, Medeiros Frescura Duarte MM, Monteiro SG, Mazzanti CM, Dos Anjos Lopes ST |
| المصدر: | Experimental parasitology [Exp Parasitol] 2013 Mar; Vol. 133 (3), pp. 357-64. Date of Electronic Publication: 2012 Dec 25. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 0370713 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2449 (Electronic) Linking ISSN: 00144894 NLM ISO Abbreviation: Exp Parasitol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Orlando, FL : Academic Press Original Publication: New York. |
| مواضيع طبية MeSH: | Iron/*metabolism , Trypanosomiasis/*metabolism, Anemia, Iron-Deficiency/immunology ; Anemia, Iron-Deficiency/parasitology ; Animals ; Antimicrobial Cationic Peptides/blood ; Bone Marrow/metabolism ; Dogs ; Erythrocyte Count ; Erythrocyte Indices ; Ferritins/metabolism ; Hematocrit ; Hemoglobins/analysis ; Hemosiderin/metabolism ; Hepcidins ; Immune System/metabolism ; Iron/blood ; Male ; Parasitemia/immunology ; Parasitemia/parasitology ; Protein Precursors/blood ; Rats ; Rats, Wistar ; Transferrin/metabolism ; Trypanosoma/growth & development ; Trypanosomiasis/blood ; Trypanosomiasis/complications ; Trypanosomiasis/immunology |
| مستخلص: | The aim of this study was to evaluate biochemical parameters of iron metabolism in rats experimentally infected with Trypanosoma evansi. To this end, 20 rats (Wistar) were intraperitoneally inoculated with blood containing trypomastigotes 10(6) (Group T) and 12 animals were used as negative control (Group C) and received saline (0.2 mL) through same route. Blood samples were collected by cardiac puncture on day 5 (C5, T5) and 30 (C30, T30) post-inoculation (pi) to perform complete blood count and determination of serum iron, transferrin, ferritin, total and latent iron fixation capacity, transferrin saturation and prohepcidin concentration. Also, bone marrow samples were collected, to perform Pearls staining reaction. Levels of iron, total and latent iron binding capacity and prohepcidin concentration were lower (P<0.05) in infected rats (T5 and T30 groups) compared to controls. On the other hand, levels of transferrin and ferritin were higher when compared to controls (P<0.05). The transferrin saturation increased on day 5 pi, but decreased on day 30 pi. The Pearls reaction showed a higher accumulation of iron in the bone marrow of infected animals in day 5 pi (P<0.01). Infection with T. evansi in rats caused anemia and changes in iron metabolism associated to the peaks of parasitemia. These results suggest that changes in iron metabolism may be related to the host immune response to infection and anemic status of infected animals. (Copyright © 2012 Elsevier Inc. All rights reserved.) |
| المشرفين على المادة: | 0 (Antimicrobial Cationic Peptides) 0 (Hemoglobins) 0 (Hepcidins) 0 (Protein Precursors) 0 (Transferrin) 9007-73-2 (Ferritins) 9011-92-1 (Hemosiderin) E1UOL152H7 (Iron) |
| تواريخ الأحداث: | Date Created: 20121229 Date Completed: 20130411 Latest Revision: 20131121 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.exppara.2012.12.010 |
| PMID: | 23270806 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1090-2449 |
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| DOI: | 10.1016/j.exppara.2012.12.010 |