دورية أكاديمية
Suppressors of ipl1-2 in components of a Glc7 phosphatase complex, Cdc48 AAA ATPase, TORC1, and the kinetochore.
العنوان: | Suppressors of ipl1-2 in components of a Glc7 phosphatase complex, Cdc48 AAA ATPase, TORC1, and the kinetochore. |
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المؤلفون: | Robinson LC; Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA., Phillips J, Brou L, Boswell EP, Tatchell K |
المصدر: | G3 (Bethesda, Md.) [G3 (Bethesda)] 2012 Dec; Vol. 2 (12), pp. 1687-701. Date of Electronic Publication: 2012 Dec 01. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
اللغة: | English |
بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101566598 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2160-1836 (Electronic) Linking ISSN: 21601836 NLM ISO Abbreviation: G3 (Bethesda) Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2021- : [Oxford] : Oxford University Press Original Publication: Bethesda, MD : Genetics Society of America, 2011- |
مواضيع طبية MeSH: | Kinetochores/*metabolism , Saccharomyces cerevisiae/*metabolism , Saccharomyces cerevisiae Proteins/*metabolism, Adenosine Triphosphatases/genetics ; Adenosine Triphosphatases/metabolism ; Amino Acid Sequence ; Aurora Kinases ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cytoskeletal Proteins ; G2 Phase Cell Cycle Checkpoints ; GTPase-Activating Proteins/genetics ; GTPase-Activating Proteins/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; M Phase Cell Cycle Checkpoints ; Molecular Sequence Data ; Mutation ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Phosphorylation ; Protein Phosphatase 1/genetics ; Protein Phosphatase 1/metabolism ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Saccharomyces cerevisiae/growth & development ; Saccharomyces cerevisiae Proteins/genetics ; Sequence Alignment ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Valosin Containing Protein |
مستخلص: | Ipl1/Aurora B is the catalytic subunit of a protein kinase complex required for chromosome segregation and nuclear division. Before anaphase, Ipl1 is required to establish proper kinetochore-microtubule associations and to regulate the spindle assembly checkpoint (SAC). The phosphatase Glc7/PP1 opposes Ipl1 for these activities. To investigate Ipl1 and Glc7 regulation in more detail, we isolated and characterized mutations in the yeast Saccharomyces cerevisiae that raise the restrictive temperature of the ipl-2 mutant. These suppressors include three intragenic, second-site revertants in IPL1; 17 mutations in Glc7 phosphatase components (GLC7, SDS22, YPI1); two mutations in SHP1, encoding a regulator of the AAA ATPase Cdc48; and a mutation in TCO89, encoding a subunit of the TOR Complex 1. Two revertants contain missense mutations in microtubule binding components of the kinetochore. rev76 contains the missense mutation duo1-S115F, which alters an essential component of the DAM1/DASH complex. The mutant is cold sensitive and arrests in G2/M due to activation of the SAC. rev8 contains the missense mutation ndc80-K204E. K204 of Ndc80 corresponds to K166 of human Ndc80 and the human Ndc80 K166E variant was previously shown to be defective for microtubule binding in vitro. In a wild-type IPL1 background, ndc80-K204E cells grow slowly and the SAC is activated. The slow growth and cell cycle delay of ndc80-K204E cells are partially alleviated by the ipl1-2 mutation. These data provide biological confirmation of a biochemically based model for the effect of phosphorylation on Ndc80 function. |
References: | Mol Biol Cell. 2011 Mar 15;22(6):759-68. (PMID: 21270439) Curr Biol. 2011 Jun 7;21(11):942-7. (PMID: 21640906) Cell. 2005 Sep 9;122(5):723-34. (PMID: 16143104) EMBO J. 1997 Apr 15;16(8):1876-87. (PMID: 9155014) J Biol Chem. 2007 Feb 2;282(5):3282-92. (PMID: 17142459) Mol Cell Biol. 1996 Jun;16(6):2922-31. (PMID: 8649403) FASEB J. 1995 May;9(8):576-96. (PMID: 7768349) Mol Cell Biol. 1995 Apr;15(4):2037-50. (PMID: 7891699) Genetics. 1993 Nov;135(3):677-91. (PMID: 8293973) Curr Biol. 2012 Feb 7;22(3):231-6. (PMID: 22209527) Cell. 1991 Jan 11;64(1):149-57. (PMID: 1846086) J Cell Sci. 2010 Jun 15;123(Pt 12):2025-34. (PMID: 20483956) Trends Biochem Sci. 2007 Jan;32(1):6-11. (PMID: 17142044) Mol Cell. 2010 May 14;38(3):383-92. (PMID: 20471944) Genetics. 1997 Mar;145(3):615-26. (PMID: 9055072) J Cell Biol. 2008 Apr 21;181(2):241-54. (PMID: 18426974) PLoS One. 2008 Feb 20;3(2):e1617. (PMID: 18286174) J Biol Chem. 2003 Sep 19;278(38):36430-4. (PMID: 12857735) Biochemistry. 2007 Aug 7;46(31):8909-19. (PMID: 17630778) Mol Biol Cell. 2008 Mar;19(3):1032-45. (PMID: 18172024) J Cell Sci. 2000 Aug;113 ( Pt 15):2685-93. (PMID: 10893184) Genes Dev. 1999 Mar 1;13(5):545-55. (PMID: 10072383) Mol Cell Biol. 1994 Feb;14(2):896-905. (PMID: 8289829) J Cell Sci. 2002 Jan 1;115(Pt 1):195-206. (PMID: 11801737) Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):3994-9. (PMID: 21368139) Mol Biol Cell. 2011 Apr 15;22(8):1217-26. (PMID: 21325630) Chem Biol. 2009 Apr 24;16(4):365-71. (PMID: 19389623) Genes Dev. 2012 Mar 15;26(6):615-29. (PMID: 22426537) Yeast. 1998 Jul;14(10):953-61. (PMID: 9717241) J Cell Biol. 2010 Oct 4;191(1):61-74. (PMID: 20921135) Nat Cell Biol. 2008 Apr;10(4):407-14. (PMID: 18364702) J Biol Chem. 2002 Dec 6;277(49):47331-7. (PMID: 12226088) EMBO J. 2009 Sep 2;28(17):2511-31. (PMID: 19629042) Science. 2009 Mar 6;323(5919):1350-3. (PMID: 19150808) Dev Cell. 2008 Oct;15(4):603-16. (PMID: 18854144) Curr Biol. 2009 Jul 28;19(14):1182-7. (PMID: 19592248) Nat Cell Biol. 2012 Feb 02;14(2):117-23. (PMID: 22298039) Nat Struct Mol Biol. 2005 Feb;12(2):138-43. (PMID: 15640796) Trends Cell Biol. 2011 Mar;21(3):133-40. (PMID: 21106376) Nucleic Acids Res. 1992 Mar 25;20(6):1425. (PMID: 1561104) J Cell Biol. 1999 Jun 28;145(7):1381-94. (PMID: 10385519) J Biol Chem. 2003 Nov 28;278(48):47744-52. (PMID: 14506263) Nature. 1995 Aug 31;376(6543):745-53. (PMID: 7651533) Genetics. 2009 Dec;183(4):1591-5. (PMID: 19822728) J Cell Biol. 2009 Feb 9;184(3):373-81. (PMID: 19193623) Curr Opin Cell Biol. 2012 Feb;24(1):48-56. (PMID: 22154944) Genetics. 2012 Apr;190(4):1355-64. (PMID: 22367039) J Cell Biol. 1969 Oct;43(1):40-50. (PMID: 5824068) J Cell Biol. 2010 Mar 22;188(6):809-20. (PMID: 20231380) Mol Cell Biol. 1994 Jul;14(7):4731-40. (PMID: 8007975) Nat Rev Mol Cell Biol. 2007 Oct;8(10):798-812. (PMID: 17848966) J Cell Biol. 1998 Nov 16;143(4):1029-40. (PMID: 9817759) Nat Biotechnol. 2003 Aug;21(8):921-6. (PMID: 12872131) BMC Dev Biol. 2009 Feb 19;9:14. (PMID: 19228425) Dev Cell. 2004 Feb;6(2):253-68. (PMID: 14960279) Mol Cell Biol. 1995 Jul;15(7):3777-85. (PMID: 7791785) Dev Cell. 2007 Sep;13(3):433-45. (PMID: 17765685) Cell. 2000 Aug 4;102(3):279-91. (PMID: 10975519) Mol Cell. 2003 Dec;12(6):1353-65. (PMID: 14690591) J Cell Biol. 1992 Mar;116(6):1421-30. (PMID: 1311712) Mol Cell. 2005 Jan 21;17(2):277-90. (PMID: 15664196) Proteomics. 2012 Jan;12(2):236-40. (PMID: 22106047) Nature. 2006 Mar 23;440(7083):565-9. (PMID: 16415853) Mol Cell Biol. 1995 Nov;15(11):6064-74. (PMID: 7565759) J Cell Biol. 2010 May 17;189(4):641-9. (PMID: 20479465) J Cell Biol. 2009 Feb 9;184(3):383-90. (PMID: 19188492) Cell. 2011 Sep 2;146(5):709-19. (PMID: 21884933) Mol Cell Biol. 1995 Jul;15(7):3767-76. (PMID: 7791784) Cell. 1989 Jun 16;57(6):987-96. (PMID: 2544297) EMBO J. 1996 Dec 2;15(23):6629-40. (PMID: 8978689) Nature. 2007 Dec 20;450(7173):1258-62. (PMID: 18097415) Mol Biol Cell. 2007 Jul;18(7):2503-10. (PMID: 17460120) Cell. 1990 Oct 5;63(1):33-46. (PMID: 2170019) Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9873-8. (PMID: 16777964) Trends Biochem Sci. 2010 Aug;35(8):450-8. (PMID: 20399103) Genes Dev. 1999 Mar 1;13(5):517-22. (PMID: 10072380) Mol Cell. 2005 Apr 29;18(3):379-91. (PMID: 15866179) Curr Biol. 1993 Jan;3(1):13-26. (PMID: 15335873) Mol Biol Cell. 2008 Nov;19(11):4852-62. (PMID: 18716057) Mol Cell Biol. 2006 Apr;26(7):2648-60. (PMID: 16537909) Genes Dev. 2009 Dec 15;23(24):2887-99. (PMID: 19948764) Mol Cell. 2009 Mar 13;33(5):537-45. (PMID: 19285938) PLoS One. 2010 Apr 01;5(4):e9938. (PMID: 20368978) Cell. 2008 May 2;133(3):427-39. (PMID: 18455984) Mol Cell Biol. 1994 May;14(5):3158-65. (PMID: 8164671) Mol Biol Cell. 2003 Jan;14(1):107-17. (PMID: 12529430) J Cell Biol. 2001 Nov 26;155(5):763-74. (PMID: 11724818) Dev Cell. 2011 Jun 14;20(6):739-50. (PMID: 21664573) J Cell Biol. 1993 Jul;122(1):53-65. (PMID: 8391002) Curr Biol. 2009 Jul 28;19(14):1176-81. (PMID: 19592249) J Cell Biol. 2010 May 17;189(4):713-23. (PMID: 20479468) J Cell Biol. 2010 Sep 20;190(6):965-73. (PMID: 20855502) J Mol Biol. 1990 Oct 5;215(3):403-10. (PMID: 2231712) Eukaryot Cell. 2004 Apr;3(2):318-30. (PMID: 15075262) Oncogene. 2011 Jul 21;30(29):3248-60. (PMID: 21399659) |
فهرسة مساهمة: | Keywords: Aurora B; GLC7; IPl1; NDC80; kinetochore |
المشرفين على المادة: | 0 (BEM2 protein, S cerevisiae) 0 (Cell Cycle Proteins) 0 (Cytoskeletal Proteins) 0 (GTPase-Activating Proteins) 0 (Intracellular Signaling Peptides and Proteins) 0 (NDC80 protein, human) 0 (Nuclear Proteins) 0 (Saccharomyces cerevisiae Proteins) 0 (TORC1 protein complex, S cerevisiae) 0 (Transcription Factors) EC 2.7.11.1 (Aurora Kinases) EC 2.7.11.1 (IPL1 protein, S cerevisiae) EC 2.7.11.1 (Protein Serine-Threonine Kinases) EC 3.1.3.16 (GLC7 protein, S cerevisiae) EC 3.1.3.16 (Protein Phosphatase 1) EC 3.6.1.- (Adenosine Triphosphatases) EC 3.6.4.- (CDC48 protein, S cerevisiae) EC 3.6.4.6 (Valosin Containing Protein) |
تواريخ الأحداث: | Date Created: 20130101 Date Completed: 20130603 Latest Revision: 20211203 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC3516489 |
DOI: | 10.1534/g3.112.003814 |
PMID: | 23275890 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2160-1836 |
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DOI: | 10.1534/g3.112.003814 |